A new mouse strain for the analysis of invariant NKT cell function

Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell–Mediated Autoimmunity

“…Apart from conventional CD4 T cells, invariant NKT (iNKT) helper cells are an additional source of B cell help, specifically for B cells reactive against glycolipids, including those of microbial origin (44-46). To clarify the relevance of iNKT cell help in mediating B cell activation and Ab production in Malt1PD animals, we generated Malt1PD mice deficient in iNKT cells via an intercross with Traj18 2/2 mice (36). We observed no difference in serum Ab levels compared with Malt1PD 3 Traj18 +/+ littermate controls (Fig.…”

Cellular and molecular regulation of innate inflammatory responses

“…[170][171][172] Advances in genomics, transcriptomics, proteomics, metabolomics, interactomics, phenomics have illustrated the complex networks of immune cells and molecules in the settings of health and diseases. 173 Development of new mouse strains such as the mouse strain lacking iNKT cells 174 and new disease models such as the mice with myeloid-cell-specific deletion of A20 as a new model of rheumatoid arthritis 175 have provided useful tools for immunological studies. Cell fate mapping and in vivo imaging technologies have enabled real-time, dynamic and in situ assessment of the activity and function of immune system.…”

Type II NKT Cells and Their Emerging Role in Health and Disease

“…Furthermore adoptive transfer of type II NKT cells (defined as NK1.1+ T cells from sulfatide injected mice) in obese mice improved weight loss and stabilized glucose homeostasis in recipients (61). Recent studies have shown that the defect in TCR repertoire in Jα18 −/− mice is broader than just iNKT cells(62), which may impact interpretation of studies relying simply on comparing the phenotype in CD1d −/− mice (that lack both type I and II NKT cells) and Jα18−/− mice and may benefit from utilization of newly developed strains to study iNKT cells(63). …”