A new model using platelet indices to predict liver fibrosis in patients with chronic hepatitis B infection

Abstract

MPV and PDW are independent variables determining the severity of liver fibrosis, and the regression model that is established using these parameters along with other markers, may give more information about the severity of liver fibrosis.

Could mean platelet volume be a useful marker for infectious diseases? a review of literature

“…Aside from their function in haemostasis, platelets have also a crurical role in the inflammatory response, and also their counts may change in parallel with the severity of infections [1][2][3][4][5][6][7][8][9][10][11]. In addition to changes in platelet counts during infections, platelet sizes can be altered by some factors such as platelet formation from megakaryocytes in response to thrombocytopenia or the release of platelet granules due to the activation of platelets [1][2][3][4].…”

Investigation of Mean Platelet Volume, Platelet Distribution Width and Erythrocyte Distribution Width in Patients with Hepatitis B Virus Infection

“…However, Ceylan et al (4) reported that low MPV values and high PDW values were associated with severe liver fibrosis in patients with hepatitis B. Uluca et al (10) found no difference in MPV values between inactive HBV carriers and controls.…”

“…However, the method is expensive and its invasive nature limits its use in some cases due to complications and contraindications (4). For this reason, non-invasive parameters are used to predict liver histology (5,6,7,8).…”

“…Mean platelet volume (MPV) and platelet distribution width (PDW) are some parameters in complete blood count (CBC), which define thrombocyte size and the extent of diversity in thrombocyte size (4). MPV is also a marker of inflammation and its severity (11).…”

Can mean platelet volume be a novel predictive marker in patients with pelvic inflammatory disease?

“…Secondly, it was demonstrated that autoimmune disorders, thrombocytopenia, congestive heart failure, acute pulmonary emboli, thyroid functional abnormalities, local or systemic infections, malignancy, inflammatory diseases, and many drugs may potentially affect MPV levels [3]. It would have been better, if the authors had mentioned these other MPV effecting factors while evaluating the associations between MPV and PID.…”