A New Model to Improve the Prediction of Prognosis of Endometrial Carcinoma by Combining Traditional Classification With the Presence of Tumor-infiltrating Lymphocytes

Abstract

Background/Aim: We aimed to predict the prognosis of endometrial carcinoma by combining traditional histological classification with the status of tumor-infiltrating lymphocytes (TILs). Patients and Methods: All patients with endometrial carcinoma, treated at our hospital, were classified into four categories-Category I: Type I positive for TILs; category II: type I negative for TILs; category III: type II positive for TILs; and category IV: type II negative for TILs. Prognoses were compared across all the categories. Positivity for TILs was defined as a continuously formed thick zone of TILs at the invasive front. Results: Multivariate analyses of progression-free and overall survival indicated that category classification was an independent prognostic factor, with hazard ratios of 3. 127, 3.483, and 8.459 for progression-free survival, and 3.444, 4.374, and 11.058 for OS for patients in categories II, III, and IV, respectively. Conclusion: Combining traditional histological classification with TIL status might better predict prognosis of endometrial carcinoma. Patients and MethodsPatients with endometrial carcinoma who underwent surgery at the National Defense Medical College in Japan between 1989 and 2017 were identified. Cases with other carcinoma types, or prior history of chemotherapy before surgery, as well as those without medical records and surgical specimens were excluded.

Improved Progression-Free Survival Associated with Tumor-Infiltrating Lymphocytes in High-Grade Endometrial Cancer

“…TILs have been associated with high-grade histology, as well as molecular subtypes of mismatch repair (MMR) deficiency, which reflect an increase in immunogenicity induced by neoantigens in response to high mutational load [ 18 ]. However, whether TILs are associated with patient outcomes independent of histology factors and MMR status remains unclear [ 19 , 20 ]. In this study, we aimed to investigate the association between TILs and survival outcomes in patients with primary EC.…”

Mesonephric-like Adenocarcinoma of the Uterine Corpus: Clinicopathological and Prognostic Significance of L1 Cell Adhesion Molecule (L1CAM) Over-expression

“…Endometrial carcinoma is the most common gynecological malignancy in the United States, with approximately 66,000 new cases reported annually (1)(2)(3)(4)(5). Notably, the number of new endometrial carcinoma cases is on a steady rise in the Republic of Korea (6).…”