A New Model for the Study of the Abdominal Compartment Syndrome in Rats

Correlation of CO2 pneumoperitoneal pressures between rodents and humans

“…Recent studies on the subject demonstrated CVP elevation following increase in intra-abdominal pressure during pneumoperitoneum in humans as well as in rodents [19,20].…”

Hepatic microvascular changes in rat abdominal compartment syndrome

“…In ACS, a local (abdominal) and systemic inflammatory response is known to develop, which is associated with decreases in peripheral perfusion and subsequent ischemia often ensues [4,20]. In this model of ACS, we were able to demonstrate and describe the microvascular response associated in the liver of experimental rats, paralleled with changes in transaminase levels (AST and ALT).…”

“…Each of these techniques have also been associated with deficits in methodology such as the induction of an inflammatory process when air insufflation is used via a mechanism of lipopolysaccharidosis [17]. The instillation of inert mediums such as gel-based solutions [20] was not chosen so as to avoid any issues that could arise with the presence of a film of the instillant on the viscera during intravital video microscopic analysis (IVVM). The use of crystalloid fluids has been shown to cause shifts in the hemodynamics in animal models [13,19,22].…”

Evaluation of a simple valve mechanism used to stabilize intraabdominal pressure during surgically induced pneumoperitoneum in small animals

“…Concerning the cardiorespiratory aspect, reports have shown that increasing the intraabdominal CO 2 pressure may lead to respiratory acidosis and bradicardya, probably secondary to increased absorption and elevated blood content of CO 2 [20]. Findings also have demonstrated that increased IAP and consequent reduction in cardiac output may significantly reduce splanchnic arterial blood flow, promoting visceral ischemia, which is more severe in the intestine [21,22]. Recent studies have shown that not only elevated levels of IAP generate systemic repercussions.…”

“…Sudden and erratic elevations of intraabdominal pressure (IAP) can lead to a variety of adverse events during laparoscopic procedures such as decreased venous return, impaired ventilation, gas embolism, subcutaneous emphysema, and even abdominal compartment syndrome [15,17,[19][20][21][22], especially in newborns [23,24]. Because of these risks, laparoscopic insufflators have been developed that allow the intraperitoneal pressure to be preset and controlled by using feedback pressure regulation.…”