A new method using MRI to delineate areas of head and neck cancer targeted by intra-arterial infusion via a superficial temporal artery

Nakamura, Tatsuya; Fuwa, Nobukazu; Takayama, Kohei; Tomoda, Takuya; Takada, Akinori; Makita, Chiyoko; Shiomi, Miho; Yokouchi, Junichi; Watanabe, Kazuo

doi:10.1016/j.oraloncology.2011.03.010

Cited by 14 publications

(4 citation statements)

References 7 publications

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“…Carcinomas are occasionally supplied by plural arteries (Nakamura et al. ): lingual and facial arteries for carcinoma of the tongue or floor of the mouth and maxillary and facial arteries for those of maxillary and mandibular gingivae or buccal mucosa. The facial artery is selected for superselective intra‐arterial infusion chemotherapy for carcinomas of the head and neck, because this artery often supplies the extensive head and neck regions.…”

Section: Discussionmentioning

confidence: 99%

Variation in arterial supply to the floor of the mouth and assessment of relative hemorrhage risk in implant surgery

Katsumi

Tanaka

Hayashi

et al. 2011

Clinical Oral Implants Res

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Section: Discussionmentioning

confidence: 99%

Variation in arterial supply to the floor of the mouth and assessment of relative hemorrhage risk in implant surgery

Katsumi

Tanaka

Hayashi

et al. 2011

Clinical Oral Implants Res

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“…When the primary tumor extends over the midline, the other catheter was inserted into the contralateral side to achieve bilateral arterial injection. The pigment injection test using indigotindisulfonate sodium, digital subtraction angiography, and flow-check MRI [32] can enable the catheter to be placed at the appropriate position and help detect tumors by confirming the enhancement of the feeding area form the catheter. The dose of cisplatin was 20–40 mg/m 2 over 5 h, once a week, for four to six times.…”

Section: Methodsmentioning

confidence: 99%

Proton Beam Therapy Combined with Intra-Arterial Infusion Chemotherapy for Stage IV Adenoid Cystic Carcinoma of the Base of the Tongue

Takayama

Katō

Nakamura

et al. 2019

Cancers

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Adenoid cystic carcinoma (ACC) is a very rare epithelial tumor of the salivary glands. Surgical resection is considered to be a standard therapy. However, the optimal treatment strategy for managing advanced cases has not yet been established. This study evaluated the efficacy and toxicity of proton beam therapy (PBT) combined with selective intra-arterial infusion chemotherapy (IAIC) using weekly cisplatin for locally advanced ACC of the base of the tongue. Between March 2009 and February 2018, 15 patients were treated. The median follow-up duration was 56 (range: 15–116) months. The 5-year local control and overall survival rates were 89% and 76%, respectively. With regard to late toxicities, grade 2 osteoradionecrosis was found in one patient and grade 5 pharyngeal necrosis was observed in one patient. Considering most cases were significantly advanced and inoperable, this therapy was effective in controlling the primary tumor, preserving function and maintaining the quality of life. Although improvements are needed to reduce adverse events, PBT in combination with IAIC can be a treatment option for locally advanced ACC of the base of the tongue.

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“…If the primary tumor extended beyond the median line into the contralateral side, another catheter was inserted into the contralateral side for bilateral arterial injection. The extent of the arterial injection was confirmed by injecting an extremely low-dose contrast medium into the tumor with an arterial injection catheter and evaluating with digital subtraction angiography and MRI [ 30 ] ( Figure 3 ).…”

Section: Methodsmentioning

confidence: 99%

Proton Beam Therapy in Combination with Intra-Arterial Infusion Chemotherapy for T4 Squamous Cell Carcinoma of the Maxillary Gingiva

Endo

Takayama

Mitsudo

et al. 2018

Cancers

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This study aimed to evaluate the therapeutic effect and toxicity of proton beam therapy in combination with intra-arterial infusion chemotherapy in patients with squamous cell carcinoma of the maxillary gingiva. Between December 2010 and March 2016, 30 patients with T4 squamous cell carcinoma of the maxillary gingiva were treated with radiotherapy and retrograde intra-arterial infusion chemotherapy using cisplatin (20–40 mg/m2, 4–6 times). Radiotherapy was basically administered using boost proton beam therapy for primary tumor and neck lymph node tumors, following 36–40 Gy photon radiation therapy delivered to the prophylactic area, to a total dose of 70.4–74.8 Gy. The median follow-up was 33 months. The 3-year local control and overall survival rates were 69% and 59%, respectively. Major grade 3 or higher acute toxicities included mucositis, neutropenia, and dermatitis in 12 (40%), 5 (17%), and 3 (10%) patients, respectively. No grade 3 or higher late toxicities were observed. These results suggested that proton beam therapy in combination with intra-arterial infusion chemotherapy was not inferior to other treatment protocols and should be considered as a safe and effective option in patients with T4 squamous cell carcinoma of the maxillary gingiva.

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A new method using MRI to delineate areas of head and neck cancer targeted by intra-arterial infusion via a superficial temporal artery

Cited by 14 publications

References 7 publications

Variation in arterial supply to the floor of the mouth and assessment of relative hemorrhage risk in implant surgery

Variation in arterial supply to the floor of the mouth and assessment of relative hemorrhage risk in implant surgery

Proton Beam Therapy Combined with Intra-Arterial Infusion Chemotherapy for Stage IV Adenoid Cystic Carcinoma of the Base of the Tongue

Proton Beam Therapy in Combination with Intra-Arterial Infusion Chemotherapy for T4 Squamous Cell Carcinoma of the Maxillary Gingiva

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