A New Method to Monitor Visual Field Defects Caused by Photoreceptor Degeneration by Quantitative Optical Coherence Tomography

Fischer, Manuel; Fleischhauer, Johannes; Gillies, Mark C; Sutter, Florian; Helbig, Horst; Barthelmes, Daniel

doi:10.1167/iovs.08-2003

Cited by 59 publications

(52 citation statements)

References 14 publications

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“…In their cohort of patients with ABCA4-associated retinopathy that included RP, they showed that the repeated microperimetry tests showed reasonable concordance and the test-retest variance was not significant. Changes on the SD-OCT have been used in several studies to study the disease progression, [13][14][15][16] and by the same measure may be useful in monitoring response to therapy.…”

Section: Discussionmentioning

confidence: 99%

“…13 Several studies have highlighted the importance of the IS/OS layer integrity in studying the progression of RP. [13][14][15] Studies have also shown the gradual reduction in the IS/OS layer assessed by the fundus autofluorescence (FAF) ring. 16 In a study in 2011, Lupo et al 17 studied the relation between SD-OCT and microperimetry in RP.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of structure and function of the macula in patients with retinitis pigmentosa

Battu

Khanna

Hegde³

et al. 2015

Eye

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Purpose To correlate the structure of the macula, as measured by spectral-domain optical coherence tomography (SD-OCT) and function, as measured by microperimetry (MAIA) in patients with retinitis pigmentosa (RP) and relatively good visual acuity. Design Prospective, cross-sectional, nonintervention study. Subjects Patients with RP. Methods Thirty patients with RP and good central visual acuity were identified. Each patient underwent SD-OCT of the macula and microperimetry. The images were overlaid using the custom-designed software. The retinal sensitivity by microperimetry was correlated with corresponding retinal thickness, as measured by the SD-OCT. ELM, COST, and IS/OS junction were scored as intact, disrupted, or absent. Main outcome measures Comparing the retinal sensitivity on the MAIA with various measurements on the SD-OCT. Results The retinal sensitivity on the MAIA showed a significant correlation with total retinal thickness and outer retinal thickness on the SD-OCT. There was no association with either the inner retinal thickness or the choroidal thickness. ORT showed a statistically significant correlation with the anatomical classification of ELM (r = − 0.76, Po0.001), IS/OS (r = − 0.800, Po0.001), and COST (r = − 0.733, Po0.001). Conclusion This study determined that there was a high correlation of the structure and function of the central macula in patients with RP. These studies are important to establish surrogate markers that can be used as end points for various tests in future therapeutic clinical trials.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation of structure and function of the macula in patients with retinitis pigmentosa

Battu

Khanna

Hegde³

et al. 2015

Eye

View full text Add to dashboard Cite

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“…Spectral-domain OCT (SD-OCT) has enabled the high-resolution visualization of retinal morphology, showing clearly distinguishable hyperreflective layers: choroidal vessels, Bruch's membrane, retinal pigment epithelium (RPE), interdigitation zone (IZ), ellipsoid zone (EZ), external limiting membrane (ELM), outer plexiform layer (OPL), inner plexiform layer (IPL), and retinal nerve fiber layer (RNFL) [6,7,8]. As a noninvasive retinal imaging technology, SD-OCT has significantly increased our understanding of the structural changes in retinal disease [4,9], and the well-established method has helped to evaluate the morphological changes related to retinal function in RP patients [10,11].…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

“…The results showed that normal retinal thickness was observed with normal visual thresholds, and reduced retinal thickness was accompanied by elevated rod and cone thresholds. Recent studies showed that visual field decreased linearly with the thinning of photoreceptor outer segment thickness [6,25], and the length of the EZ line corresponded with a sharp drop in visual field sensitivity [8,12]. The visual field extent was lost in RP patients without detectable photoreceptor outer segments [25].…”

Section: Photoreceptor Segmentsmentioning

confidence: 99%

Optical Coherence Tomographic Analysis of Retina in Retinitis Pigmentosa Patients

Liu

Liu²,

Li³

et al. 2016

Ophthalmic Res

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Retinitis pigmentosa (RP) is a progressive inherited retinal disease characterized by nyctalopia, visual field constriction, and reduced full-field electroretinograms. The progressive loss of photoreceptors leads to vision loss at the end stage of RP. The prevalence of RP is approximately 1/4,000. Since it is one of the major causes of visual impairment worldwide, morphological and functional assessments are useful for estimating the retinal structure and function in RP. Optical coherence tomography (OCT) is a well-established method of examining retinal structure in situ, and the obtained images by OCT help to analyze morphological abnormalities. Changes revealed by OCT have provided insights into the pathology of RP as well as for predicting the prognosis of RP. In this review, we present the typical morphological changes in RP and their relationships with visual function in eyes with RP.

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“…For instance, eyes with the declined receptor layer thickness [12, 14] or a thinner photoreceptor outer segment [13, 15] have reportedly presented a reduced visual function. In addition, the length of the ellipsoid zone (EZ) line has been reported to correspond to a sharp decline in the visual field sensitivity [14, 17].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Visual Function and Structural Characteristics of the Macula in Advanced Retinitis Pigmentosa

et al. 2019

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We aimed to correlate the visual function and structural characteristics of the retina and choroid in advanced retinitis pigmentosa (RP) patients. A cross-sectional, retrospective review was conducted of medical records of 149 RP patients who reported visual field constriction on a central 30-2 Humphrey visual field chart. Using spectral domain-optical coherence tomography, central foveal thickness (CFT), ellipsoid zone (EZ) length, macular volume (MV), and submacular choroidal thickness (SMChT) were measured. A control cohort (68 eyes of 68 patients) was included for comparing the macular structure. Quantitative correlations between visual function indices [visual field index (VFI) and best-corrected visual acuity (BCVA)] and structural indices (CFT, EZ length, and SMChT) were evaluated. Mean age was 46.3 ± 15.5 years; mean illness duration was 60.7 ± 60.0 months. SMChT was thinner than that in normal controls. Per Pearson’s correlation, BCVA and VFI exhibited a progressive worsening related to age and disease duration. In multivariate linear regression, BCVA and VFI were significantly correlated with CFT, EZ length, and MV at the central 1-mm area. Among RP patients with visual field constriction within 30°, VFI and BCVA closely correlate with the degree of retinal structural change, including the CFT, EZ length, and MV. SMChT uniformly decreased in this study population and exhibited no significant correlation with BCVA or VFI degree.

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A New Method to Monitor Visual Field Defects Caused by Photoreceptor Degeneration by Quantitative Optical Coherence Tomography

Cited by 59 publications

References 14 publications

Correlation of structure and function of the macula in patients with retinitis pigmentosa

Correlation of structure and function of the macula in patients with retinitis pigmentosa

Optical Coherence Tomographic Analysis of Retina in Retinitis Pigmentosa Patients

Correlation between Visual Function and Structural Characteristics of the Macula in Advanced Retinitis Pigmentosa

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