A new method providing complementary explanation of the blood‐enriching function and mechanism of unprocessed <i>Angelica sinensis</i> and its four kinds of processed products based on tissue‐integrated metabolomics and confirmatory analysis

Ji, Peng; Li, Chen-chen; Wei, Yanming; Hua, Yuejin; Yao, Wan-Ling; Wu, Fanlin; Zhang, Xiaosong; Yuan, Ziwen; Zhao, Nian-shou; Zhang, Yahui; Wen, Yeong-Ray

doi:10.1002/bmc.5252

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Multi-target and mechanism explorations of herbal medicine and natural products can be studied through innovative integration technologies. An integrating metabolomics was established to explain the blood-supplementation mechanism of Angelica sinensis (AS), which was related to linoleic acid, l-cystathionine, aspartic acid and l-alanine metabolic pathways [151]. Metabolomics analyses have identified EGCG and myricitrin as α-glucosidase inhibitors from dried leaves of Syzygium polyanthum leaves [152].…”

Section: Multi-target and Effect Mechanism Exploration Of Herbal Medi...mentioning

confidence: 99%

Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification

Lin,

Tian,

Guo

et al. 2024

Molecules

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As links between genotype and phenotype, small-molecule metabolites are attractive biomarkers for disease diagnosis, prognosis, classification, drug screening and treatment, insight into understanding disease pathology and identifying potential targets. Metabolomics technology is crucial for discovering targets of small-molecule metabolites involved in disease phenotype. Mass spectrometry-based metabolomics has implemented in applications in various fields including target discovery, explanation of disease mechanisms and compound screening. It is used to analyze the physiological or pathological states of the organism by investigating the changes in endogenous small-molecule metabolites and associated metabolism from complex metabolic pathways in biological samples. The present review provides a critical update of high-throughput functional metabolomics techniques and diverse applications, and recommends the use of mass spectrometry-based metabolomics for discovering small-molecule metabolite signatures that provide valuable insights into metabolic targets. We also recommend using mass spectrometry-based metabolomics as a powerful tool for identifying and understanding metabolic patterns, metabolic targets and for efficacy evaluation of herbal medicine.

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Section: Multi-target and Effect Mechanism Exploration Of Herbal Medi...mentioning

confidence: 99%

Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification

Lin,

Tian,

Guo

et al. 2024

Molecules

View full text Add to dashboard Cite

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Research Progress in Pharmacological Effects and Mechanisms of Angelica sinensis against Cardiovascular and Cerebrovascular Diseases

Chen,

Fan,

Wang

et al. 2024

Molecules

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Angelica sinensis (Oliv.) Diels (A. sinensis) is a medicinal and edible values substance, which could promote blood circulation and enrich blood. It possesses rich chemical components and nutrients, which have significant therapeutic effects on cardiovascular and cerebrovascular diseases. It is commonly used for the prevention and treatment of cardiovascular and cerebrovascular diseases in the elderly, especially in improving ischemic damage to the heart and brain, protecting vascular cells, and regulating inflammatory reactions. This article reviews the main pharmacological effects and clinical research of A. sinensis on cardiovascular and cerebrovascular diseases in recent years, explores the effect of its chemical components on cardiovascular and cerebrovascular diseases by regulating the expression of functional proteins and inhibiting inflammation, anti-apoptosis, and antioxidant mechanisms. It provides a reference for further research on A. sinensis and the development of related drugs. It provides a new reference direction for the in-depth research and application of A. sinensis in the prevention, improvement, and treatment of cardiovascular and cerebrovascular diseases.

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A new method providing complementary explanation of the blood‐enriching function and mechanism of unprocessed Angelica sinensis and its four kinds of processed products based on tissue‐integrated metabolomics and confirmatory analysis

Cited by 2 publications

References 31 publications

Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification

Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification

Research Progress in Pharmacological Effects and Mechanisms of Angelica sinensis against Cardiovascular and Cerebrovascular Diseases

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