A New Method of Determining the Solute Permeability of Hollow-Fiber Dialysis Membranes by Means of Laser Lights Traveling Along Optic Fibers

Blood and dialysate flow patterns in hollow-fiber dialyzers are complicated, and hence the flow patterns and mass transfer are difficult to analyze theoretically. Consequently, dialyzers are usually developed by a trial-and-error method. We attempt to design dialyzers by computer simulation analysis in this work. Blood-side and dialysate-side flows were modeled using the Hagen-Poiseuille equation and the Blake-Kozeny equation, respectively. These flow patterns were evaluated as pressure drop and velocity distribution. The mass transfer rate was evaluated as solute clearance. Computed values of the pressure drops and clearance for urea and vitamin B12 were found to agree closely with those obtained experimentally. We evaluated the influences of the inner diameter of hollow fibers, module geometry, and void fraction on the pressure drop and clearance, and computer-aided design was performed.

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“…6 The overall mass transfer coefficient, KL (mm/s), was calculated by 6 The overall mass transfer coefficient, KL (mm/s), was calculated by…”

Section: Methods Of Computationmentioning

confidence: 99%

Computer-aided design of hollow-fiber dialyzers

2001

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“…Diffusive permeability was measured at 310 K by means of a radioisotope technique (Sakai et al, 1987(Sakai et al, , 1988 in the case of HTO, and by means of a photoabsorption technique using optical fibers (Ohmura et al, 1989;Kanamori et al, 1994) in the case of the other solutes. Both of these methods are free from the influence of solute transfer due to convection and make it possible to measure permeability due solely to diffusion.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of dialysis membranes using a tortuous pore model

Kokubo

Sakai

1998

AIChE Journal

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“…With APS-15E and FB-150U membranes, diffusive permeability for tryptophan, Vitamin B 2 , Vitamin B 12 (Wako Pure Chemical Industries, Ltd., Osaka, Japan) was measured by the optical fiber method we have proposed [8,[10][11][12]. Physical property of test solutes is summarized in Table 2.…”

Section: Diffusive Permeabilitymentioning

confidence: 99%