A new method for99mTc generator preparation

Reactor Production of Radionuclides for Generators

“…Alumina column; solvent extraction of pertechnetate [2,7,16]; sublimation [10,13,19]; zirconium molybdate gel [5,10,12]; titanium molybdate gel [11,17,18]. Cost: 120-150$ Ci -1 ; sterile generators: 150-250$.…”

“…Specific activities ranging from a few Ci per gram to several Ci per milligram of the parent are generally used for generators suited for reliable repeated elutions. The specific activity of the parent, however, needs not to be very high if the parent element is converted into a column matrix, as in the case of the gel generators for 99m Tc [5,11,12,18],…”

99mTc Gel Generators Based on Zirconium Molybdate-99Mo: I. Process Standardisation for Production

“…The early encouraging findings by Australian [1,2] and Indian [3][4][5] researchers through the metallic molybdate gel route paved the way for extensive and systematic studies using this approach. While the pioneer Australian scientists vigorously pursued the concept of conversion of (n,y) produced "Mo to zirconium molybdate-"Mo (Zr"Mo) gel [6,7], the Indian efforts were concentrated on the use of neutron irradiated titanium molybdate (TiMo) as column matrix [8].…”

Magnesium-Molybate Compounds as Matrix for 99Mo/99mTc Generators

“…99 Mo/ 99m Tc generator based on heteropolyanions such as zirconium molybdate, titanium molybdate, molybdocerates, etc. , [ 6 - 12 ] have been developed by some laboratories around the world. This is due to the molybdates' matrix capacity to incorporate up to 30% in weight of 99 Mo [ 13 ] compared to 0.2% in traditional alumina based generators.…”

“…Although these generators has opened a way of making column type 99m Tc generator even using low and medium specific activity 99 Mo, the handling problems (precipitation, filtration drying, fragmentation, etc. ) still exist because these 99 Mo-molybdates are mostly synthesized from 99 Mo, requiring sophisticated remote handling facilities and at least 6 h processing time [ 12 , 14 ]. To simplify the production process of these systems, we propose preparing 99 Mo/ 99m Tc generators based on magnesium 99 Mo-molybdate compounds by synthesizing magnesium molybdate compounds, followed by irradiation.…”