A New Method for the Synthesis of Pyrrolo[1,2-a]quinolines Based on Boron Trifluoride-Mediated Cyclization of 1-(2-Oxiranylphenyl)pyrroles

Abstract

A simple synthesis of pyrrolo[1,2-a]quinolines carrying no substituent at all of the 1-to 5-positions based on boron trifluoride-mediated cyclization of 1-(2-oxiranylphenyl)pyrroles, which can be easily prepared from 2-(pyrrol-1yl)benzaldehydes, is described.We previously described a boron trifluoride catalyzed synthesis of 3-aminopyrrolo[1,2-a]quinolin-4-ol