Abstract:Procaine is one of the oldest local anesthetics used in medicine. When absorbed and entering the systemic circulation reduces the excitability of peripheral cholinoreactive systems. Has a blocking effect on the autonomic ganglia, reduces smooth muscle spasms, and reduces the excitability of the myocardium and motor areas of the cerebral cortex. It is synthesized by oxidizing 4-nitrotoluene to 4-nitrobenzoic acid, which is subsequently reacted with thionyl chloride, the resulting acid chloride is then esterifie… Show more
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