A new method for the assessment of endothelial function with peripheral arterial volume

Abstract

BackgroundCurrently, many methodological approaches have been developed to assess peripheral endothelial function. However, a development of the noninvasive and automated technique for routinely assessing endothelial function is still required. We evaluated the potential value of a new method to measure peripheral endothelial function with reactive hyperemia peripheral arterial volume (RH-PAV) in patients with chest pain.MethodsWe used a novel oximeter-like probe to detect the peripheral arterial volume (PAV) of the finger and compared it with brachial flow-mediated dilation (FMD) performed in 93 consecutive patients with chest pain. The RH-PAV index was defined as the ratio of the digital pulse volume during reactive hyperemia relative to the baseline.ResultsNinety-three patients (53 men, 58 ± 5 years) completed the study, and 53 patients demonstrated coronary artery disease (CAD) following scheduled coronary angiography. There was a moderate linear relationship between PAV and FMD (r = 0.69, p < 0.01). Similar to FMD, PAV was more impaired in patients who have more cardiovascular risk factors (CRFs). The subjects with CAD had lower PAV and FMD, compared with those without CAD (1.05 ± 0.23 VS. 1.41 ± 0.37, p < 0.01; 6.7% ± 2.9% VS. 10.4% ± 2.9%, p < 0.01, respectively), and the relationships between FMD and PAV were also significant in both CAD (r = 0.54, p < 0.01) and non-CAD (r = 0.62, p < 0.01) patients.ConclusionsEndothelial function of digital artery assessed with the novel PAV method demonstrated a profile similar to that of brachial artery measured with FMD. The hyperemia PAV was decreased by factors which were considered to impair endothelial function, suggesting that PAV has the potential to be a novel method to study endothelial function.

A new peripheral endothelial function measurement improves prediction of symptomatic coronary artery disease

“…Furthermore, PAV was reduced in patients with established CAD, which is consistent with our previous study. 5 As a conventional predictor of the risk of CAD, the AFRS shows a strong positive correlation with the prevalence of significant CAD. 22 In the present study, we adopted the AFRS as the baseline model to assess the probability of CAD before CAG.…”

“…Moreover, peripheral artery volume (PAV) technology is a newly developed method for quantifying peripheral endothelial function during reactive hyperemia. 5 The basic principle of PAV is the same as that of peripheral arterial tonometry (PAT). PAT technology assesses the arterial pulse wave amplitude of the finger by a pressure sensor, while PAV records pulsatile hemoglobin flow as a surrogate for blood flow volume with a photoplethysmographic finger probe.…”

Endothelial dysfunction in children with pyelonephritis

“…32359 "Method for diagnosing endothelium-dependent vasodilatation in children", IPC Measurement of flow-dependent dilatation of the brachial artery according to ultrasound data is currently considered as the «gold standard» for the endothelial function of vessels study [4,17,18,20]. The study method is high-tech and non-invasive, which greatly simplifies and accelerates the diagnosis of ED in children with various pathology [2,11,17,19]. Endothelium-dependent vasodilatation (EDVD) test was performed as follows: patients were examined in the supine position after a 10-15-minute rest, at least a 10-hour fast and abstention from coffee, tea, bad habits and exercise.…”

The latest applications of photoplethysmography

“…Daoyuan's team examined 93 people (53 with coronary heart disease) and concluded that PAV may provide as accurate results as FMD, while being easier to perform. Moreover, the authors indicated that PAV has the potential to become a non-invasive method of early identification of patients at high risk of coronary artery disease [47].…”