A new method for synthesis of allenes, including an optically active form, from aldehydes and alkenyl aryl sulfoxides with carboncarbon bond-formation

An Efficient Catalytic Procedure for the Selective Oxidation of Sulfides to Sulfoxides by Citric Acid/Al(NO3)3.9H2O/MBr Under Mild and Heterogeneous Conditions

“…3 Selective oxidation of sulfides to the sulfoxides remains a challenge and is interesting because corresponding sulfoxides are valuable synthetic intermediates for the synthesis of chemically and biologically important significant molecules. [4][5][6] Sulfoxides are also valuable in C-C bond-forming 7,8 and molecular rearrangements. [9][10][11] Additionally some of biologically active sulfoxides play an important role as therapeutic agents.…”

Synthesis of Allenes by 1,2-Elimination

“…Synthesis of allenes by alkenylation of magnesium carbenoids Satoh and co-workers have also reported an asymmetric synthesis of allenes such as 131 (a sex attractant of the male bean weevil) relying on magnesium-sulfoxide exchange (Scheme 32). [73] Enantioenriched vinyl sulfoxide 129 was lithiated with LDA and then trapped with an aldehyde to generate a diastereoisomeric mixture of the corresponding allylic alcohols. Reaction with Ac2O afforded diastereomeric acetates 130a and 130b which could be separated by column chromatography.…”

A Novel Catalytic Method for the Oxidation of Sulfides to Sulfoxides with Silica Sulfuric Acid and Sodium Nitrite in the Presence of KBr and/or NaBr as Catalyst

“…5 Selective oxidation of sulfides to the sulfoxides remains a challenge and is interesting because corresponding sulfoxides are valuable synthetic intermediates for the synthesis of chemically and biologically important significant molecules. [6][7][8] Sulfoxides are also valuable in C -C bond-formation 9,8 and molecular rearrangements. [10][11][12][13] Additionally some of biologically active sulfoxides play an important role as therapeutic agents such as anti-ulcer, [14][15][16] antibacterial, 17 antifungal, 7 anti-atherosclerotic reagents, 18,19 etc.…”