A new method for studying working memory by using the three-panel runway apparatus in rats.

Furuya, Yasubumi; Yamamoto, Tsuneyuki; Yatsugi, Shin-ichi; Ueki, Showa

doi:10.1254/jjp.46.183

Cited by 50 publications

(21 citation statements)

References 20 publications

(2 reference statements)

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“…However, as Hodges [89] argues, the role of motivation in spatial learning is not clear, as working memory tasks in different food reward mazes (i.e. RAM and 3-door runway) result in different performances in hippocampal lesioned animals [61,92,98]. Nevertheless, stress is likely to be a key confounding factor in cognitive performance in spatial memory tasks.…”

Section: Comparison Between the Radial Arm Maze And Morris Water Mazementioning

confidence: 99%

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

et al. 2009

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Emerging evidence suggests that a group of dietary-derived phytochemicals known as flavonoids are able to induce improvements in memory, learning and cognition. Flavonoids have been shown to modulate critical neuronal signalling pathways involved in processes of memory, and therefore are likely to affect synaptic plasticity and long-term potentiation mechanisms, widely considered to provide a basis for memory. Animal dietary supplementation studies have further shown that flavonoidrich foods are able to reverse age-related spatial memory and spatial learning impairments. A more accurate understanding of how a particular spatial memory task works and of which aspects of memory and learning can be assessed in each case, are necessary for a correct interpretation of data relating to diet-cognition experiments. Further understanding of how specific behavioural tasks relate to the functioning of hippocampal circuitry during learning processes might be also elucidative of the specific observed memory improvements. The overall goal of this review is to give an overview of how the hippocampal circuitry operates as a memory system during behavioural tasks, which we believe will provide a new insight into the underlying mechanisms of the action of flavonoids on cognition.

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Section: Comparison Between the Radial Arm Maze And Morris Water Mazementioning

confidence: 99%

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

et al. 2009

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“…Systemic scopolamine also deteriorates working memory in the three-panel runway task (10,11). Okaichi et al (31) reported that scopolamine impairs not only the working memory but also the reference memory of rats in the eight-arm radial maze with 4 arms baited.…”

Section: Discussionmentioning

confidence: 99%

“…Working and reference memory were assess ed by a three-panel runway apparatus (10,11). The apparatus (175 X 36 X 25 cm, length X width X height) is composed of a start box, a goal box, and four consecutive intervening choice points.…”

Section: Three-panel Runway Taskmentioning

confidence: 99%

“…The locations of the correct panel-gates were held constant within a ses sion, but were changed from one session to the next. Thus, twelve patterns of correct panel-gate locations were used in this experi ment, as described previously (10,11). In the reference memory task, three consecutive trials were given each day at 2-min intervals (one session).…”

Section: Three-panel Runway Taskmentioning

confidence: 99%

“…We previously reported a new method for the study of learning and memory in rats, us ing a three-panel runway apparatus (10,11). In the present study, we investigated the ac quisition and retention of the runway perfor mance of rats with dorsal hippocampal lesions based on working and reference memory pro cedures.…”

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confidence: 95%

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Working and Reference Memory in Rats in the Three-Panel Runway Task Following Dorsal Hippocampal Lesions.

et al. 1992

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Using a three-panel runway task, the influence of dorsal hippocampal lesions on working and reference memory in rats was investigated. Despite 20 postop erative training sessions, rats with hippocampal lesions were unable to perform the working memory task. In the acquisition process of the reference memory task, however, there was no significant difference between hippocampal and sham-lesioned rats. On the other hand, rats trained preoperatively with a working memory proce dure, and then subjected to hippocampal lesions, showed more errors (pushes made on the two incorrect panels of the three panel-gates located at four choice points) than did sham-lesioned rats. The increase in working errors induced by hippocampal lesions was not reduced during 10 subsequent re-training sessions. Hippocampal le sions had no effect on retention of the reference memory performance. The increase in working errors in hippocampal-lesioned rats was significantly reduced by treatment with the cholinesterase inhibitor physostigmine at 0. 1 mg/kg and the cholinergic acti vating drug minaprine at 10 mg/kg. These findings suggest that lesions of the dorsal hippocampus selectively impair the ability to carry out the working memory task whether rats are trained preoperatively or postoperatively, and that the working mem ory loss in hippocampal-lesioned rats is mediated by lowering of the cholinergic func tion.

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Repeated Acquisition and Performance Chamber for Mice: A Paradigm for Assessment of Spatial Learning and Memory

Brooks

Cory‐Slechta

Murg

et al. 2000

Neurobiology of Learning and Memory

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A new method for studying working memory by using the three-panel runway apparatus in rats.

Cited by 50 publications

References 20 publications

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

Working and Reference Memory in Rats in the Three-Panel Runway Task Following Dorsal Hippocampal Lesions.

Repeated Acquisition and Performance Chamber for Mice: A Paradigm for Assessment of Spatial Learning and Memory

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