A new method for radiochemical separation of arsenic from irradiated germanium oxide

Vascular Imaging of Solid Tumors in Rats with a Radioactive Arsenic-Labeled Antibody that Binds Exposed Phosphatidylserine

“…Jennewein and Rö sch have developed efficient methods for isolating arsenic from irradiated germanium oxide targets to provide arsenic in a form that is useful for labeling sensitive biomolecules (7,8). They have also developed novel methods for linking arsenic to biomolecules.…”

“…Radiochemistry has now evolved, and several isolation procedures for arsenic isotopes have been reported. Most recently, Jennewein and Rö sch developed efficient methods for isolating pure radionuclides from irradiated GeO 2 targets on the basis of a solid phase extraction system (7,8). Moreover, Jennewein and Rö sch proposed chemistry for the effective labeling of biologically relevant molecules, as we have now exploited.…”

“…Bavituximab is currently in phase I clinical trials in patients with various solid tumors. 7 Despite its proven ability to target tumor endothelium, bavituximab has not yet been explored as an imaging agent. The vascular location of phosphatidylserine ensures ready access by radiolabeled antibody in the blood.…”

Chelator‐Free Synthesis of a Dual‐Modality PET/MRI Agent

“…[1] However, the use of arsenic isotopes has been quite scarce due to limited availability, because of difficulties related to isotope production, separation, and purity of the radionuclides. [4] Furthermore, few techniques are currently available for incorporation of these radionuclides into biologically relevant targeting vectors. To the best of our knowledge, labeling antibodies and polymers through covalent interaction of radioactive arsenite, i.e., *As(III), with sulfhydryl groups is the only reported method, [5] while techniques for labeling of radioactive arsenate, i.e., *As(V), are still unavailable.…”

Radiolabeled Nanoparticles in Nuclear Oncology

“…Although As radioisotopes are not widely used because of limited availability and difficulties related to their production, separation and purification of the radioisotopes [32], Chen F. et al (2013) employed a simple, chelator-free and efficient protocol to synthesize *As-radiolabeled SPIONs functionalized with a layer of oleic acid (OA) surfactant which was later replaced by poly(acrylic acid) (PAA), leading to higher stability of the NPs in biological solutions. Further coating with PEG made the system more stable, showing high liver uptake and significantly decreased bladder uptake, results also confirmed by PET imaging [33].…”