A NEW METHOD FOR ONE-POT SYNTHESIS OF ARYLOXYPHENOXYPROPIONATE HERBICIDES USING 2,4,6-TRICHLORO-1,3,5-TRIAZINE AND (n-BU)4NI AS A HOMOGENEOUS CATALYST

Abstract

The one-pot reaction of halo-heterocycle, (R)-4-hydroxyphenoxy propionic acid and an alcohol, amine or sulfonamide is described as an efficient method for the synthesis of aryloxyphenoxy propionate hrerbicides by using 2,4,6-trichloro-1,3,5-triazine in the presence of ( n-Bu) 4 NI, as a homogeneous catalyst under mild conditions. The present procedure offers several advantages, such as good yields, short reaction times and easy workup.

In VitroInhibitory and Cytotoxic Activity of MFM 501, a Novel Codonopsinine Derivative, against Methicillin-ResistantStaphylococcus aureusClinical Isolates

“…Furthermore, MFM 501 has a good yield of 20 to 60% as exemplified by the other similar pyrrolidine compounds previously reported using a one-pot reaction [ 22 ]. Besides giving out good yield of intended compounds, the advantages of one-pot reaction schemes include reduction of the time required to set up the reactions, removal of the need to isolate unstable intermediates, and reduction of the time required for purifications which would lead to lowering the cost of overall reaction and lessening wastage to the environment [ 49 , 50 ].…”

Binary Solid–Liquid Solubility Determination and Model Correlation of Quizalofop-p-ethyl in Different Pure Solvents

“…The melting temperature T m of quizalofop- p -ethyl had been reported in previous literatures; , however, the fusion enthalpy Δ fus H of quizalofop- p -ethyl has not been determined. In order to obtain the Δ fus H of quizalofop- p -ethyl, a differential scanning calorimetric instrument (Pyris-Diamond, PerkinElmer) was used to measure the Δ fus H of quizalofop- p -ethyl.…”

“… a This work, determined at 101.2 kPa. The standard uncertainties u are u ( T ) = 0.51 K, u ( p ) = 0.45 kPa, and u (Δ fus H ) = 0.42 kJ·mol –1 . b Taken from ref . c Taken from ref . d Calculated with the Advanced Chemistry Development (ACD/Laboratories) Software V11.02 (1994–2016 ACD/Laboratories). e Taken from ref . g High-performance liquid phase chromatograph. h Gas chromatography. …”

“…100646-51-3, Figure ) is a new novel selective herbicide discovered in 1979 and developed by Nissan Chemical Industries, Ltd. It is a post-emergence herbicide for the selective control of annual and perennial grass weeds primarily in broadleaf crops. , In addition, it is a highly effective class of herbicide due to its high activity, high selectivity, and low toxicity . As a result, it has been used effectively in a number of crops, including soybeans and cereal grains, such as wheat and rice, to control grass weeds.…”

“…As a result, it has been used effectively in a number of crops, including soybeans and cereal grains, such as wheat and rice, to control grass weeds. It has broad prospects for raw drug synthesis and pharmaceutical processing. , Up to now, it has been commercialized and marketed by major agrochemical companies at home and abroad. At present, two main ways have been reported to synthesize quizalofop- p -ethyl. ,− One method is using 2,6-dichloroquinoxaline as a raw material, esterification with hydroquinone to obtain 4-(6-chloro-2-quinoxalinyloxy) phenol, and then condensation with ethyl p -toluenesulfonyl lactate.…”