A new method for measurement of left atrial volumes using 64-slice spiral computed tomography: Comparison with two-dimensional echocardiographic techniques

Christiaens, Luc; Lequeux, Benoît; Ardilouze, P.; Ragot, Stéphanie; Mergy, Jean; Herpin, D.; Bonnet, Benjamin; Allal, J

doi:10.1016/j.ijcard.2007.10.020

Cited by 54 publications

(60 citation statements)

References 34 publications

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“…This finding is consistent with previous studies indicating that both 2-and 3-dimensional TTE systematically underestimates LA volumes by 23-34% when compared with CMR, MSCT or contrast ventriculography [19][20][21][22]. This underestimation is partly a result of different conventions in LA volume measurements.…”

Section: Discussionsupporting

confidence: 92%

Assessment of left atrial volume and function: a comparative study between echocardiography, magnetic resonance imaging and multi slice computed tomography

Kühl

Lønborg

Fuchs

et al. 2011

Int J Cardiovasc Imaging

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Measurement of left atrial (LA) maximal volume (LA(max)) using two-dimensional transthoracic echocardiography (TTE) provides prognostic information in several cardiac diseases. However, the relationship between LA(max) and LA function is poorly understood and TTE is less well suited for measuring dynamic LA volume changes. Conversely, cardiac magnetic resonance imaging (CMR) and multi-slice computed tomography (MSCT) appears more appropriate for such measures. We sought to determine the relationship between LA size assessed with TTE and LA size and function assessed with CMR and MSCT. Fifty-four patients were examined 3 months post myocardial infarction with echocardiography, CMR and MSCT. Left atrial volumes and LA reservoir function were assessed by TTE. LA time-volume curves were determined and LA reservoir function (cyclic change and fractional change), passive emptying function (reservoir volume) and pump function (left atrial ejection fraction-LAEF) were derived using CMR and MSCT. Left atrial fractional change and left atrial ejection fraction (LAEF) determined with CMR and MSCT were unrelated to LA(max) enlargement by echocardiography (P = NS). There was an overall good agreement between CMR and MSCT, with a small to moderate bias in LA(max) (4.9 ± 10.4 ml), CC (3.1 ± 9.1 ml) and reservoir volume (3.4 ± 9.1 ml). TTE underestimates LA(max) with up to 32% compared with CMR and MSCT (P < 0.001). Left atrial function assessed with MSCT and CMR as LA fractional change and LAEF is not significantly related to LA(max) measured by TTE. TTE systematically underestimated LA volumes, whereas there are good agreements between MSCT and CMR for volumetric and functional properties.

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Section: Discussionsupporting

confidence: 92%

Assessment of left atrial volume and function: a comparative study between echocardiography, magnetic resonance imaging and multi slice computed tomography

Kühl

Lønborg

Fuchs

et al. 2011

Int J Cardiovasc Imaging

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“…In a previous study by Christiaens et al [17], the LAVmax, LAVmin and LAEF were measured using 64-MSCT, but the other left atrial functional variables were not evaluated. The left atrial function is impaired in a number of cardiovascular outcomes [2][3][4][5][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Assessing the left atrial phasic volume and function with dual-source CT: comparison with 3T MRI

Wen

Zhang

et al. 2010

Int J Cardiovasc Imaging

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We wanted to assess the performance of dual-source CT (DSCT) for evaluating the left atrial volume and function and we compared this performance to that of the standard reference technique,cardiac cine MR (CMR). Fifty-one patients who were referred for CT coronary angiography were included in the study. Two were subsequently excluded for having un-analyzable MR images at the onset of left atrial contraction. For the remaining 49 patients, the DSCT data sets and FIESTA (fast imaging employing steady-state acquisition) cines of the vertical long axis covering the left atrium and the short axis covering the left ventricle were obtained on the same day. All the images were analyzed to obtain the maximal left atrial volume (LAVmax), the minimal left atrial volume (LAVmin), the left atrial volume just before left atrium contraction (LAVp), the left atrial reservoir volume (LARV), the left atrial ejection fraction (LAEF), the left atrial passive emptying volume (LAPV), the left atrial active emptying volume(LAAV), the left atrial conduit volume (LACV), the left ventricular end-diastolic volume (LVEDV), the left ventricular end-systolic volume (LVESV) and the left ventricular stroke volume (LVSV) by using 3D semi-segmentation software and Report Card 2.0 software, respectively, for the DSCT and CMR. All the parameters were normalized to the body surface area. Intermodality agreement was tested through linear regression and Bland-Altman analyses.Repeated measurements were performed to determine the interobserver variability. The DSCT measurements resulted in good correlation (r > 0.75) compared with those of CMR. However, DSCT slightly,but insignificantly overestimated the indexed LAVmax, LAVmin, LAVp, LARV, LAPV, LAAV and LACV, as reflected by biases of 1.2, 0.9, 1.1, 0.3, 0.1,0.2 and 0.4 ml/m(2), respectively. The LAEF was minimally, but insignificantly underestimated as reflected by a bias of -0.6% (P = ns). The variability of the DSCT measurements was lower than that of the CMR values. DSCT provides highly reliable and reproducible measurements of the left atrial phasic volume and function in patients who are referred for coronary CT imaging.

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“…9 In addition, the maximum left atrial (LA) volume was calculated according to the biplane area-length method and indexed for body surface area. 18 A total of 55 mL/m 2 was defined as the upper limit for LA volume index. 19 Evaluation of LGE was performed according to the AHA-17-segment model.…”

Section: Image Analysismentioning

confidence: 99%

Myocardial Adaptation to High-Intensity (Interval) Training in Previously Untrained Men With a Longitudinal Cardiovascular Magnetic Resonance Imaging Study (Running Study and Heart Trial)

Scharf

Schmid

Kemmler

et al. 2015

Circ: Cardiovascular Imaging

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Background-To prospectively evaluate whether short-term high-intensity (interval) training (HI(I)T) induces detectable morphological cardiac changes in previously untrained men in cardiovascular magnetic resonance imaging. Methods and Results-Eighty-four untrained volunteers were randomly assigned to a HI(I) T group (n=42; 44.1±4.7 years) or an inactive control group (n=42; 42.3±5.6 years). HI(I)T focused on interval runs (intensity: 95%-105% of individually calculated heart rate at the anaerobic threshold). Before and after 16 weeks, all subjects underwent physiological examination, stepwise treadmill test with blood lactate analysis, and contrast-enhanced cardiovascular magnetic resonance imaging (cine, tagging, and delayed enhancement). Indexed left ventricular (LV) and right ventricular (RV) volume (LV, 77.1±8.5-83.9±8.6; RV, 80.5±8.5-86.6±8.1) and mass (LV, RV,.1) significantly increased with HI(I)T. Changes in LV and RV morphological parameters with HI(I)T were highly correlated with an increase in maximal aerobic capacity (VO 2max ) and a decrease in blood lactate concentration at the anaerobic threshold. Mean LV and RV remodeling index of HI(I)T group did not alter with training (0.76 ±0.09 and 0.24±0.10 g/mL, respectively [P=0. 97 and P=0.72]), indicating balanced cardiac adaptation. Myocardial circumferential strain decreased after HI(I)T within all 6 basal segments (anteroseptal, P=0.01 and anterolateral, P<0.001). There was no late gadolinium enhancement in any of the participants before or post HI(I)T. Conclusions-Sixteen Scharf et al Cardiac Adaptation to HI(I)Tinvestigations revealed enlargement and reduced contractility of the RV, which might be associated with ventricular tachycardia. 15The Running Study and Heart (RUSH) trial was designed to address these issues. Physiological and morphological data were collected and cardiopulmonary exercise testing with blood lactate analysis as well as CMR imaging was performed in a randomized controlled trial. Methods Study PopulationThe study (www.clinicaltrials.gov, NCT01406730) was approved by the institutional review board and written informed consent was obtained from all subjects. Sample size was determined with G*power (version 3.1.3; 2009, Faul et al,16 Dusseldorf, Germany). We estimated that a sample size of 32 individuals in each group would have a power of 90% to detect a between-group difference of 8±10 mL in end-diastolic volume (EDV) with α=0.05. Assuming a dropout rate of 20%, our goal was to recruit 40 subjects per group. Study subjects were recruited by local newspaper advertisement from January until March 2011. The study was conducted from April 2011 until July 2012. Participants were randomly assigned to a training and restgroup.Eighty-eight male volunteers, who were either completely sedentary or did not engage in any routine (ie, >3 hours per week) physical training, were enrolled in this study. All participants completed a medical history and physical activity questionnaire. All subjects denied the use of illicit substances and un...

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A new method for measurement of left atrial volumes using 64-slice spiral computed tomography: Comparison with two-dimensional echocardiographic techniques

Cited by 54 publications

References 34 publications

Assessment of left atrial volume and function: a comparative study between echocardiography, magnetic resonance imaging and multi slice computed tomography

Assessment of left atrial volume and function: a comparative study between echocardiography, magnetic resonance imaging and multi slice computed tomography

Assessing the left atrial phasic volume and function with dual-source CT: comparison with 3T MRI

Myocardial Adaptation to High-Intensity (Interval) Training in Previously Untrained Men With a Longitudinal Cardiovascular Magnetic Resonance Imaging Study (Running Study and Heart Trial)

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