A new method for evaluation of the autonomic nervous system in patients with idiopathic hyperhidrosis: systolic blood pressure and heart rate recovery after graded exercise

Alihanoğlu, Yusuf İzzettin; Yıldız, Bekir Serhat; Kılıç, İsmail Doğu; Saricopur, Ahmet; Öncü, Mustafa; Buber, Ipek; Taşlı, L.; Evrengül, Harun

doi:10.1111/ced.12915

Cited by 3 publications

(9 citation statements)

References 28 publications

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“…In our preliminary analysis, the HRR profiles of 25 patients with known IH and 25 HCs with no known autonomic dysfunction were assessed. In contrast to the results of Alihanoglu et al ., we found that the HRR indices were similar in patients with IH and the HCs. However, we found that the hyperbolic‐type first‐minute exercise HRR curve was more common in patients with IH than in HCs (67% vs. 28%, P = 0.02).…”

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confidence: 99%

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Complex autonomic pathways in patients with idiopathic hyperhidrosis

2017

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Because there are no original studies on imiquimodinduced autoantibodies, it is difficult to decide whether autoantibodies are generated as a result of the topical treatment. It is possible that patients with autoantibodies who do not reveal cutaneous manifestations are prone to develop LE-like skin changes after topical treatment with imiquimod.In conclusion, we present a case of topical imiquimodinduced CLE with positive anti-histone antibodies, which is the first such case, to our knowledge.

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confidence: 99%

“…We read with great interest the paper by Alihanoglu et al . published recently in Clinical and Experimental Dermatology .…”

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confidence: 97%

Complex autonomic pathways in patients with idiopathic hyperhidrosis

2017

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“…The objective of the present study was to investigate the autonomic behavior in patients diagnosed with different types of PFHH using HRV analysis in the domains of time, frequency, and nonlinearity in relation to an apparently healthy control group. Our results allowed us to conclude that although PFHH presents a basis for some autonomic dysfunction, this will necessarily or predominantly occur at the "peripheral" level, that is, in the sweat glands or in their vicinity and will not be related to HRV [15,20,21,25,39,40].…”

Section: Discussionmentioning

confidence: 74%

“…Sweat gland disorders can of-ten result in changes in sweat secretion and release of sweat to the skin surface. Current detailed studies on the cellular mechanisms involved in sweat secretion bring evidence that there are differences in the proteins that control the influx of calcium (Ca +2 ) to the interior of the cell between hyperhidrotic and control cells [39,40]. These findings suggest that changes in the intracellular mechanisms of sweat secretion may be involved in excessive sweating in HH.…”

Section: Discussionmentioning

confidence: 99%

Heart Rate Variability Assessment and Its Application for Autonomic Function Evaluation in Patients with Hyperhidrosis

et al. 2020

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Background: Pathophysiology mechanism of primary focal hyperhidrosis (PFHH) is controversial. Heart rate variability (HRV) could explain if there is a systemic component present. We aimed to investigate the functions of the autonomic nervous system in patients diagnosed with PFHH compared to controls using the analysis of HRV in the domains of time, frequency, and nonlinearity, as well as analysis of the recurrence plots (RPs). Methods: We selected 34 patients with PFHH (29.4 ± 10.2 years) and 34 controls (29.2 ± 9.6 years) for HRV analysis. Heart beats were recorded with Polar RS800CX monitor (20 min, at rest, in supine position), and RR intervals were analyzed with Kubios Premium HRV software. RPs were constructed with Visual Recurrence Analysis software. Statistical analysis included unpaired t test (p < 0.05). Results: Our results showed that HRV parameters in the 3 domains evaluated did not show any differences between the groups. The same was observed with RPs. Conclusions: The findings suggest that PFHH, from the pathophysiological point of view, may be caused by peripheral involvement of the sympathetic nervous system (glandular level or nerve terminals), as there was no difference between the groups studied. More specific studies should help elucidate this issue.

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“…The bidirectional changes in HRR over increasing and decreasing physical activity may be used to follow a physical activity intervention in RA to identify non-responder and non-adherent participants with potential hypertension risk, despite normal resting blood pressure and normal exercise ECG findings. From a practical standpoint, exercising ECG and extending it for only several minutes into exercise recovery provides a unique, minimally invasive means to assess HR and blood pressure responses to exercise to indirectly determine participant's response or adherence to physical activity and to predict the CVD risk ( 28 , 50 ), and also mainly to detect hypertension early ( 39 , 42 , 51 ). It was already reported in the literature that a delayed SBP decrease post-exercise was more accurate than ST segment depression for the diagnosis of coronary artery disease (CAD) ( 39 , 52 , 53 ).…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Autonomic Function Changes and Predictors During a 2-Year Physical Activity Program in Rheumatoid Arthritis: A PARA 2010 Substudy

et al. 2021

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Background: Chronic inflammation leads to autonomic dysfunction, which may contribute to the increased risk of cardiovascular diseases (CVD) in patients with rheumatoid arthritis (RA). Exercise is known to restore autonomic nervous system (ANS) activity and particularly its parasympathetic component. A practical clinical tool to assess autonomic function, and in particular parasympathetic tone, is heart rate recovery (HRR). The aim of this substudy from the prospective PARA 2010 study was to determine changes in HRR post-maximal exercise electrocardiogram (ECG) after a 2-year physical activity program and to determine the main predictive factors associated with effects on HRR in RA.Methods: Twenty-five participants performed physiotherapist-guided aerobic and muscle-strengthening exercises for 1 year and were instructed to continue the unsupervised physical activity program autonomously in the next year. All participants were examined at baseline and at years 1 and 2 with a maximal exercise ECG on a cycle ergometer. HRR was measured at 1, 2, 3, 4, and 5 min following peak heart rate during exercise. Machine-learning algorithms with the elastic net linear regression models were performed to predict changes in HRR1 and HRR2 at 1 year and 2 years of the PARA program.Results: Mean age was 60 years, range of 41–73 years (88% women). Both HRR1 and HRR2 increased significantly from baseline to year 1 with guided physical activity and decreased significantly from year 1 to year 2 with unsupervised physical activity. Blood pressure response to exercise, low BMI, and muscular strength were the best predictors of HRR1/HRR2 increase during the first year and HRR1/HRR2 decrease during the second year of the PARA program.Conclusion: ANS activity in RA assessed by HRR was improved by guided physical activity, and machine learning allowed to identify predictors of the HRR response at the different time points. HRR could be a relevant marker of the effectiveness of physical activity recommended in patients with RA at high risk of CVD. Very inactive and/or high CVD risk RA patients may get substantial benefits from a physical activity program.

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A new method for evaluation of the autonomic nervous system in patients with idiopathic hyperhidrosis: systolic blood pressure and heart rate recovery after graded exercise

Cited by 3 publications

References 28 publications

Complex autonomic pathways in patients with idiopathic hyperhidrosis

Complex autonomic pathways in patients with idiopathic hyperhidrosis

Heart Rate Variability Assessment and Its Application for Autonomic Function Evaluation in Patients with Hyperhidrosis

Cardiovascular Autonomic Function Changes and Predictors During a 2-Year Physical Activity Program in Rheumatoid Arthritis: A PARA 2010 Substudy

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