A New Method for Cannulation of the Abomasum in Sheep

Kondos, AC

doi:10.1111/j.1751-0813.1967.tb08924.x

Cited by 13 publications

(6 citation statements)

References 4 publications

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“…Three, 9-12-month-old Border Leicester-Merino crossbred wether sheep were surgically fitted with permanent sampling cannulae in the rumen (Godwin & Chaffey, 1988) and the pyloric region of the abomasum (Kondos, 1967). The sheep were housed, in an air-conditioned room, in individual metabolism cages which allowed the separate collection of urine and faeces.…”

Section: Animalssupporting

confidence: 93%

The effect of level of feed intake on the pharmacokinetic disposition and efficacy of ivermectin in sheep

Ali

Hennessy

1996

Vet Pharm & Therapeutics

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The kinetic disposition of orally administered [3H]-Ivermectin (IVM) was examined in sheep in which the feed intake was maintained at either 800 or 400 g/day. The [3H]-metabolites were almost completely associated with particulate digesta in the rumen. In the low feed intake group the digesta flow was slower than in sheep on high feed intake. This resulted in an extended residence time and greater availability of IVM and its metabolites. The anthelmintic efficacy of IVM was then examined in sheep in which feed intake was reduced from 800 g/day to 400 g/36 h prior to and 36 h after IVM administration. In sheep with reduced intake 97% of IVM-resistant Haemonchus contortus were removed, compared with 53% in sheep maintained on high feed intake.

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Section: Animalssupporting

confidence: 93%

The effect of level of feed intake on the pharmacokinetic disposition and efficacy of ivermectin in sheep

Ali

Hennessy

1996

Vet Pharm & Therapeutics

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“…Placement of abomasal cannulas in 5-d-old calves was described by Stewart and Nicolai (1964), who reported less leakage when the cannulas were exteriorized high on the left side of the animal. The insertion of cannulas prepared from rubber stoppers was described by Kondos (1967). He described the use of surgical adhesive for adhering the cannula to the abomasum.…”

Section: Cannula Typesmentioning

confidence: 99%

Considerations for gastrointestinal cannulations in ruminants.

Harmon

Richards

1997

Journal of Animal Science

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The complexity of ruminant digestion necessitates a greater variety and complexity of experimental methods than with any other species. The fact that dietary ingredients are first subjected to microbial fermentation requires elaborate measures to ascertain nutrients presented for absorption. Numerous approaches have been attempted to obtain representative samples of digesta at sites throughout the gastrointestinal tract. The choices of a researcher before an experiment include animal(s), site(s) for cannula placement, style of cannula, cannula material, and numerous other more subtle factors that may contribute to the success of an experiment. This review compares the advantages and disadvantages of various approaches, cannula types, and cannula materials that should be considered before experiments are conducted.

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“…Four Merino wether sheep weighing 25-28 kg and four Angora wether goats, 18-24 kg, all between 9 and 12 months of age, were given a single dose of 200 pg ivermectinikg (IVO-MEC, MSD Australia) to remove any existing nematodes. Two weeks prior to the start of experiments, the animals were surgically fitted with a sampling cannula in the pyloric abomasum following the procedure described by Kondos (1967). An infusion catheter was placed in the rumen using a trocar technique.…”

Section: Animalsmentioning

confidence: 99%

Comparative kinetic disposition of oxfendazole in sheep and goats before and during infection with Haemonchus contortus and Trich ostrongylus colubriformis

Hennessy

Sangster

Steel

et al. 1993

Vet Pharm & Therapeutics

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The kinetic disposition of [14C]-oxfendazole (OFZ) and its metabolites, fenbendazole (FBZ) and fenbendazole sulphone (FBZ.SO2), in plasma and abomasal fluid were determined in Merino sheep and Angora goats before and during infection with Trichostrongylus colubriformis and Haemonchus contortus. The systemic availability (area under the plasma curve, AUC) of OFZ was significantly lower in goats (13.5 micrograms.h/ml) than in sheep (22.2 micrograms.h/ml) and was reduced with infection in goats (5.6 micrograms.h/ml) and sheep (15.1 micrograms.h/ml). The elimination of plasma [14C] was faster in goats than in sheep. The responses observed for [14C] were a reflection of the behaviour of OFZ. The concentration of OFZ and metabolites in abomasal fluid were similar in both species in the absence or presence of infection. However, as the mean flow rate of abomasal fluid was slower in goats (240 ml/h) than in sheep (488 ml/h), only 7% of the dose passed the pylorus in abomasal fluid of goats compared with 14% in sheep. The presence of gastrointestinal nematodes generally increased abomasal fluid flow rate but neither species nor infection had any effect on the rate or extent of [14C] excretion in urine or faeces. It is suggested that goats possess a faster hepatic metabolism than sheep resulting in more rapid elimination of OFZ.

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A New Method for Cannulation of the Abomasum in Sheep

Cited by 13 publications

References 4 publications

The effect of level of feed intake on the pharmacokinetic disposition and efficacy of ivermectin in sheep

The effect of level of feed intake on the pharmacokinetic disposition and efficacy of ivermectin in sheep

Considerations for gastrointestinal cannulations in ruminants.

Comparative kinetic disposition of oxfendazole in sheep and goats before and during infection with Haemonchus contortus and Trich ostrongylus colubriformis

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