A new method for active surveillance of adverse events from diphtheria/tetanus/pertussis and measles/mumps/rubella vaccines

Neutralization Activity and Persistence of Antibodies Induced in Response to Vaccination with a Novel Mumps Strain, RIT 4385

“…In 1992 the distribution of Pluserix™ was voluntarily suspended in countries where an alternative was available, following concerns over the number of cases (estimated at 1 per 2,600 vaccinees) of aseptic meningitis associated with the Urabe Am 9 mumps strain [2,3]. A third MMR vaccine, Triviraten™ (Swiss Berna), with the Rubini mumps strain elicits good antibody responses but has poor efficacy against mumps resulting in epidemics in Switzerland [4,5], Italy [6] and Portugal [7].…”

Surveillance of Measles-Mumps-Rubella Vaccine-Associated Aseptic Meningitis in Germany

“…In reviewing these cases the two clinical experts applied the tighter time frame of 15-35 days post vaccination to indicate causality rather than the 6-week period on the monthly report cards. It is well documented that the characteristic post-vaccination period for mumps vaccine complications is 15-35 days, while complications due to the measles component usually occur during 6-11 days post vaccination [4,9,13].The criteria used to define a case of associated MMR vaccine viral aseptic meningitis are shown in table 1.…”

“…In a record linkage study in the UK [9], the risk of aseptic meningitis following vaccination with the Urabe strain of mumps was found to be higher compared to the risk following vaccination with the other widely used mumps strain Jeryl-Lynn.This led in 1992 to the discontinuation of use of vaccines containing the Urabe mumps strain in some countries, including Germany [10], where vaccination continued with two MMR vaccines containing the Jeryl-Lynn mumps strain.…”

Verdachtsfälle unerwünschter Arzneimittelwirkungen (UAW) nach Anwendung von Impfstoffen mit attenuierter Masern-Komponente

“…Das ist ein Schwachpunkt und eine Grenze des Systems und erfordert Überlegungen zur Etablierung neuer aktiver Überwachungssysteme (z. B. Verknüpfung von großen Datenbanken [25]). …”