A New Meroterpene, A New Benzofuran Derivative and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Acremonium persicinum KUFA 1007 and Their Anticholinesterase Activities

Alves, Ana; Pereira, José A.; Dethoup, Tida; Cravo, Sara; Mistry, Sharad; Silva, Artur M. S.; Pinto, Madalena; Kijjoa, Anake

doi:10.3390/md17060379

Cited by 17 publications

(9 citation statements)

References 27 publications

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“…Acremine S (47) was isolated from the sponge Mycale sp. derived fungus A. persicinum KUFA 1007 and showed inhibitory activity against butyrylcholine esterase, which was three folds higher than that of galantamine [26]. Hexahydroacremonintriol (48), along with an analogue, acremonin A glucoside, were obtained from a tropical sinkhole derived from A. masseei CICY026.…”

Section: Meroterpenoidsmentioning

confidence: 99%

Recent Advances in Chemistry and Bioactivities of Secondary Metabolites from the Genus Acremonium

Qin,

Lu,

et al. 2024

JoF

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Acremonium fungi is one of the greatest and most complex genera in Hyphomycetes, comprising 130 species of marine and terrestrial sources. The past decades have witnessed substantial chemical and biological investigations on the diverse secondary metabolites from the Acremonium species. To date, over 600 compounds with abundant chemical types as well as a wide range of bioactivities have been obtained from this genus, attracting considerable attention from chemists and pharmacologists. This review mainly summarizes the sources, chemical structures, and biological activities of 115 recently reported new compounds from the genus Acremonium from December 2016 to September 2023. They are structurally classified into terpenoids (42%), peptides (29%), polyketides (20%), and others (9%), among which marine sources are predominant (68%). Notably, these compounds were primarily screened with cytotoxic, antibacterial, and anti-inflammatory activities. This paper provides insights into the exploration and utilization of bioactive compounds in this genus, both within the scientific field and pharmaceutical industry.

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Section: Meroterpenoidsmentioning

confidence: 99%

Recent Advances in Chemistry and Bioactivities of Secondary Metabolites from the Genus Acremonium

Qin,

Lu,

et al. 2024

JoF

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“…42, 14.08, 30.71, and 10.53, respectively). Compound 357 has antibacterial activity against S. aureus and B. subtilis (MIC = 25 to 100 µg/ml) and 339 has antioxidative, anti-Aβ fibrillization, and neuroprotective activities (Alves et al, 2019;Elissawy et al, 2017;Gu et al, 2018b;Lei et al, 2017).…”

Section: Terpenesmentioning

confidence: 99%

Diversity of source, chemistry, and bioactivities of secondary metabolites from algae-associated and sponge-associated fungi

Safwan,

Ridwan,

Kusuma

2023

J Appl Pharm Sci

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Marine-derived fungi have been evident sources of new secondary metabolites with an incredible diversity of structural and bioactivity. The accretion of research into discovering new secondary metabolites from marine-derived fungi has continued upward over the last few years. Marine-derived fungi have been found and isolated from various marine habitats, including sponges and algae. This review report displays the structures of new compounds isolated from algae-derived and sponge-derived fungi and their activities, covering the literature from 2017 to 2021. A total of 339 new compound structures were reported in this study, of which 169 compounds were distributed from algae-derived fungi and 170 were isolated from sponge-derived fungi. The compounds distributed were classified as alkaloids, aromatics, lactones, peptides, polyketides, pyrones, steroids, and terpenes isolated from Trichoderma sp., Aspergillus sp., Penicillium sp., Alternaria sp., Talaromyces sp., Acremonium sp., and Pestalotiopsis sp. Based on activity, these compounds have various activities such as antibacterial, cytotoxic, antioxidant, antifungal, anti-inflammatory, and butyrylcholinesterase inhibition. Several compounds showed stronger activity than the control. In the end, a review of this report can provide information on the great potential of discovering and developing new compounds to be used as led compounds derived from marine fungi.

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“…One of the oldest metazoan animals is sponges ( Phylum porifera ) providing classic examples of microbial macro-faunal partnerships [ 90 ]. Generally, for great quantity of fungal biomass in sponge tissues, microbes can contribute over 40–70% of the sponge mass [ 30 , 91 ].…”

Section: Main Textmentioning

confidence: 99%

Marine endophytic fungal metabolites: A whole new world of pharmaceutical therapy exploration

El-Bondkly

2021

Heliyon

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The growing threat arises due to diseases such as cancer and the infections around the world leading to a critical requirement for novel and constructive compounds with unique ways of action capable of combating these deadly diseases. At present, it is evident that endophytic fungi constitute an enormous as well as comparatively untapped source of great biodiversity that can be considered as a wellspring of effective novel natural products for medical, agricultural and industrial use. Marine endophytic fungi have been found in every marine plants (algae, seagrass, driftwood, mangrove plants), marine vertebrates (mainly, fish) or marine invertebrates (mainly, sponge and coral) inter- and intra-cellular without causing any palpable symptoms of illness. Since evolution of microbes and eukaryotes to a higher level, coevolution has resulted in specific interaction mechanisms. Endophytic fungi are known to influence the life cycle and are necessary for the homeostasis of their eukaryotic hosts and the chemical signals of their host have been shown to activate gene expression in endophytes to induce expression of endophytic secondary metabolites. Marine endophytic fungi are receiving increasing attention by chemists because of their varied and structurally unmatched compounds that have strong biological roles in life as lead pharmaceutical compounds, including anticancer, antiviral, insulin mimetic, antineurodegenerative, antimicrobial, antioxidant and immuno-suppressant compounds. Moreover, fungal endophytes proved to have different biological activities for exploitation in the environmental and agricultural sustainability.

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A New Meroterpene, A New Benzofuran Derivative and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Acremonium persicinum KUFA 1007 and Their Anticholinesterase Activities

Cited by 17 publications

References 27 publications

Recent Advances in Chemistry and Bioactivities of Secondary Metabolites from the Genus Acremonium

Recent Advances in Chemistry and Bioactivities of Secondary Metabolites from the Genus Acremonium

Diversity of source, chemistry, and bioactivities of secondary metabolites from algae-associated and sponge-associated fungi

Marine endophytic fungal metabolites: A whole new world of pharmaceutical therapy exploration

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