A new look at the serology of treponemal disease.

Abstract

IntroductionThe changes that have recently taken place in the serology of treponemal disease have fortunately tended to make the subject less complicated and more rational than it was in the past; the change that has contributed most of all to this simplification is the widespread adoption of specific antibody tests, in place of the older non-specific ones, in routine testing. To explain how this change has altered the serodiagnosis of treponemal infection it is necessary to discuss briefly syphilis antibodies in general and the

The pattern of immunological responses at various stages of syphilis.

“…In this study, we have tried to delineate the immunological factors better by using a combination of tests for lipoidal The results obtained were generally consistent and pointed strongly to certain conclusions. In a recent study, O'Neill (1976) obtained similar results with fewer tests. In the present study, apart from the 20 cases of late syphilis, the sera that were negative in the.…”

Immunological responses in late syphilis.

“…[3][4][5][6][7][8][9] In contrast, Duncan and Kuhn,'°in a similar study using chimpanzees, found that production of specific antitreponemal IgM ceased spontaneously in 10 out of 24 animals who had received no treatment, and treponemal IgM reactivity in sera from patients with late syphilis.…”

A retrospective observational comparative study of VDRL vs. TPHA and their role in serodiagnosis of syphilis in a tertiary care centre

“…All reactive non treponemal test like VDRL should be confirmed by treponemal tests like TPHA and even TPHA may be required in some cases who were non-reactive to non treponemal tests based on patient's clinical history and symptoms. 6 So a combination of VDRL and TPHA provides an efficient screening for syphilis.…”