A new look at left ventricular remodeling definition by cardiac imaging

Bière, Loïc; Donal, Erwan; Jacquier, Alexis; Croisille, Pierre; Genée, Olivier; Christiaens, Luc; Prunier, Fabrice; Guéret, Pascal; Boyer, L.; Alain, Furber

doi:10.1016/j.ijcard.2016.02.009

Cited by 20 publications

(21 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although CMR is more accurate and also allows reliable estimation of the infarct size and the extension of fibrosis, its costs and restricted availability make echocardiography still the most common non-invasive tool used to quantify LV volumes and function, especially during the acute phase after MI or for serial evaluations 25. Echocardiography has been demonstrated to correlate well with CMR when quantifying LV volumes26 and it has been widely used in landmark studies assessing the prognostic role of LVR in post-MI patients12 14 25 or the predictive value of serum biomarkers 27…”

Section: Discussionmentioning

confidence: 99%

Galectin-3 predicts left ventricular remodelling after anterior-wall myocardial infarction treated by primary percutaneous coronary intervention

Tano

Caretta

Maria

et al. 2016

Heart

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Galectin-3 predicts left ventricular remodelling after anterior-wall myocardial infarction treated by primary percutaneous coronary intervention

Tano

Caretta

Maria

et al. 2016

Heart

View full text Add to dashboard Cite

show abstract

“…Pathological left ventricular remodeling (LVR) was the common characteristic of most cardiovascular diseases. It clinically defined as the adverse changes in LV mass, volume, and geometry after myocardial injury, which could be considered to be an adaptive response to cardiac performance inadequacy and a marker of poor prognosis in patients with underlying LV dysfunction . In recent years, the impact of nonhemodynamic factors on cardiac structure and function, such as obesity and other metabolic disorder, had been gradually valued.…”

Section: Introductionmentioning

confidence: 99%

Left ventricular metabolic remodeling and accompanied dysfunction in type 2 diabetic patients: A 3D speckle tracking analysis

et al. 2019

View full text Add to dashboard Cite

Purposes The purposes of our study were to determine the risk factors related to metabolic left ventricular remodeling (LVR) in type 2 diabetes mellitus (T2DM) patients and to assess the LV function with different geometry in such population. Methods Seventy‐eight T2DM patients with normal 2D‐LVEF (≥55%) were enrolled and divided into two groups with LV normal geometry (LVN) and with LV remodeling (LVR). The control group was composed of forty age‐ and sex‐matched healthy individuals with LVN. A multifactor logistic regression was used to determine the risk factors for LVR, and their diagnostic values were evaluated using the area under the ROC curves (AUC). Three‐dimensional speckle tracking echocardiography (3DSTE) was used to measure LV global longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS), and global radial strain (GRS). Results Fasting plasma glucose (FPG), hyperlipidemia, and BMI were independently associated with LVR in T2DM patients, and the AUC values were 0.699, 0.697, and 0.732, respectively. The T2DM patients with LVN showed significantly lower GLS than the controls (P < 0.05), whereas the T2DM patients with LVR showed significantly lower GLS, GCS, GAS, and GRS than the T2DM patients with LVN (all P < 0.01). Additionally, GLS, GAS, and GRS values decreased significantly in the T2DM patients with LV hypertrophy than in those with LV concentric remodeling (all P < 0.05). Conclusions The routine echocardiography and 3DSTE could be used in combining way to detect the metabolic LV remodeling and accompanied dysfunction in T2DM patients.

show abstract

“…Those maladaptive alterations occur at different myocardial levels affecting genome expression, molecular, cellular, and interstitial functions leading to LV dilation, dysfunction, and consequently, adverse clinical outcome [ 1 ]. However, the accurate determination of LV remodeling is still challenging, and until now, a consensus definition on LV remodeling is lacking [ 2 ]. A plethora of different parameters and different thresholds for the definition of LV remodeling can be found in the current literature [ 2 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Prognosis-based definition of left ventricular remodeling after ST-elevation myocardial infarction

et al. 2018

View full text Add to dashboard Cite

Objectives Cardiac magnetic resonance (CMR) is the gold-standard modality for the assessment of left ventricular (LV) remodeling in ST-elevation myocardial infarction (STEMI) patients. However, the commonly used remodeling criteria have never been validated for hard clinical events. We therefore aimed to define clear CMR criteria of LV remodeling following STEMI with proven prognostic impact. Methods This observational study included 224 patients suffering from acute STEMI. CMR was performed within 1 week and 4 months after infarction to evaluate different remodeling criteria including relative changes in LV end-diastolic volume (%∆LVEDV), end-systolic volume (%∆LVESV), ejection fraction (%∆LVEF), and myocardial mass (%∆LVMM). Primary endpoint was the occurrence of major adverse cardiovascular events (MACE) including all-cause death, re-infarction, stroke, and new congestive heart failure 24 months following STEMI. Secondary endpoint was defined as composite of primary endpoint and cardiovascular hospitalization. The Mann–Whitney U test was applied to assess differences in LV remodeling measures between patients with and without MACE. Values for the prediction of primary and secondary endpoints were assessed by c -statistics and Cox regression analysis. Results The incidence of MACE ( n = 13, 6%) was associated with higher %∆LVEDV ( p = 0.002) and %∆LVMM ( p = 0.02), whereas %∆LVESV and %∆LVEF were not significantly related to MACE ( p > 0.05). The area under the curve (AUC) for the prediction of MACE was 0.76 (95% confidence interval [CI], 0.65–0.87) for %∆LVEDV (optimal cut-off 10%) and 0.69 (95%CI, 0.52–0.85) for %∆LVMM (optimal cut-off 5%). From all remodeling criteria, %∆LVEDV ≥ 10% showed highest hazard ratio (8.68 [95%CI, 2.39–31.56]; p = 0.001) for MACE. Regarding secondary endpoint ( n = 35, 16%), also %∆LVEDV with an optimal threshold of 10% emerged as strongest prognosticator (AUC 0.66; 95%CI, 0.56–0.75; p = 0.004). Conclusions Following revascularized STEMI, %∆LVEDV ≥ 10% showed strongest association with clinical outcome, suggesting this criterion as preferred CMR-based definition of post-STEMI LV remodeling. Key Points • CMR-determined %∆LVEDV and %∆LVMM were significantly associated with MACE following STEMI. • Neither %∆LVESV nor %∆LVEF showed a significant relation to MACE. • %∆LVEDV ≥ 10 was revealed as LV remodeling definition with highest prognostic validity.

show abstract

A new look at left ventricular remodeling definition by cardiac imaging

Abstract: International audienceLeft ventricular remodeling (LVR) typically manifests as compensatory changes in ventricular mass, composition, and volume as a response to cardiac performance inadequacy..

Cited by 20 publications

References 10 publications

Galectin-3 predicts left ventricular remodelling after anterior-wall myocardial infarction treated by primary percutaneous coronary intervention

Galectin-3 predicts left ventricular remodelling after anterior-wall myocardial infarction treated by primary percutaneous coronary intervention

Left ventricular metabolic remodeling and accompanied dysfunction in type 2 diabetic patients: A 3D speckle tracking analysis

Prognosis-based definition of left ventricular remodeling after ST-elevation myocardial infarction

Contact Info

Product

Resources

About