A New Long-acting Liposomal Topical Antifungal Formula: Human Clinical Study

Abdel-Rhaman, Mohamed S.; Soliman, Wael; Habib, Fawzia; Fathalla, Dina

doi:10.1097/ico.0b013e318221cf12

Cited by 14 publications

(11 citation statements)

References 16 publications

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“…Our study suggests that to reduce the recurrence rate, it is necessary to rinse planting beds repeatedly with antifungal drugs during the surgery, and all ulcer lesions should be removed completely. Conservative treatment of fungal keratitis often disappoints because of limited tissue penetration, a narrow antimicrobial spectrum, and toxicity of the currently available antifungal agents (25,26). Furthermore, early diagnosis is difficult.…”

Section: Discussionmentioning

confidence: 99%

Lamellar Keratoplasty Treatment of Fungal Corneal Ulcers With Acellular Porcine Corneal Stroma

Zhang

Liu

Jin

et al. 2015

American Journal of Transplantation

132

115

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Section: Discussionmentioning

confidence: 99%

Lamellar Keratoplasty Treatment of Fungal Corneal Ulcers With Acellular Porcine Corneal Stroma

Zhang

Liu

Jin

et al. 2015

American Journal of Transplantation

132

115

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“…Regardless of the drug choice, successful therapy requires prolonged frequent drug administration and therefore adherence of patients to treatment is also an important factor affecting the outcome of treatment. In addition, liposomal preparation of anti-fungal drugs are also under trail and has demonstrated some efficacy in rabbit models [1,57]. Furthermore [156] compared the efficacy of topical clotrimazole-β-cyclodextrin (CBC), a comparatively new anti-fungal compared to amphotericin B and concluded that CBC reduces the period of treatment on average by a duration of 1 week.…”

Section: Treatmentmentioning

confidence: 99%

Pathogenesis of microbial keratitis

Lakhundi

Siddiqui

Khan

2017

Microbial Pathogenesis

167

121

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Microbial keratitis is a sight-threatening ocular infection caused by bacteria, fungi, and protist pathogens. Epithelial defects and injuries are key predisposing factors making the eye susceptible to corneal pathogens. Among bacterial pathogens, the most common agents responsible for keratitis include Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia and Serratia species. Fungal agents of corneal infections include both filamentous as well as yeast, including Fusarium, Aspergillus, Phaeohyphomycetes, Curvularia, Paecilomyces, Scedosporium and Candida species, while in protists, Acanthamoeba spp. are responsible for causing ocular disease. Clinical features include redness, pain, tearing, blur vision and inflammation but symptoms vary depending on the causative agent. The underlying molecular mechanisms associated with microbial pathogenesis include virulence factors as well as the host factors that aid in the progression of keratitis, resulting in damage to the ocular tissue. The treatment therefore should focus not only on the elimination of the culprit but also on the neutralization of virulence factors to minimize the damage, in addition to repairing the damaged tissue. A complete understanding of the pathogenesis of microbial keratitis will lead to the rational development of therapeutic interventions. This is a timely review of our current understanding of the advances made in this field in a comprehensible manner. Coupled with the recently available genome sequence information and high throughput genomics technology, and the availability of innovative approaches, this will stimulate interest in this field.

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“…Some drugs act extracellularly and some others act intracellularly. A paradox for the latter type of drugs is that (1) lipophilic drugs can easily penetrate the plasma membrane but they have poor solubility in the blood stream, and (2) hydrophilic drugs have good solubility in the blood stream but they can not easily penetrate the plasma membrane to reach their intracellular acting sites. Both situations would prohibit these drugs to exert satisfactory curative effects.…”

Section: Introductionmentioning

confidence: 99%

“…Drug delivery system may solve this problem. Liposomes have been used for delivering drugs [1,2], but some problems exist [3,4].…”

Section: Introductionmentioning

confidence: 99%

Liposome intracellular delivery of Salvia miltiorrhiza Bge. deprivative DS-201 improves its BKCa channel-activating and vasorelaxing effects

Yu¹,

Cheng²,

Huang³

et al. 2016

Science Bulletin

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A New Long-acting Liposomal Topical Antifungal Formula: Human Clinical Study

Abstract: Therapy with topical liposomal fluconazole (2 mg/mL) carries a high success rate and fast effect in treating patients with C. albicans keratitis.

Cited by 14 publications

References 16 publications

Lamellar Keratoplasty Treatment of Fungal Corneal Ulcers With Acellular Porcine Corneal Stroma

Lamellar Keratoplasty Treatment of Fungal Corneal Ulcers With Acellular Porcine Corneal Stroma

Pathogenesis of microbial keratitis

Liposome intracellular delivery of Salvia miltiorrhiza Bge. deprivative DS-201 improves its BKCa channel-activating and vasorelaxing effects

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