A New Laser Treatment for Vocal Cord Papilloma—585‐nm Pulsed Dye

Abstract

Patients treated with PDL experienced regression of their papillomas. PDL may provide patients with RRP with an alternative treatment without the risks associated with CO(2) laser surgery. This procedure also has potential to be delivered on an outpatient basis with flexible fiberoptic laryngoscopes.

Multi-Institutional Experience With the In-Office Potassium Titanyl Phosphate Laser for Laryngeal Lesions

“…7 Early clinical investigators have postulated that the results were because of the effects of the laser on the microcirculation of the lesion. 3,4,6 Yet our data, and those of others, [7][8][9] indicate that nonvascular lesions seem to respond similar to vascularbased lesions. We, therefore, hypothesize that these effects are because of a nonspecific thermal injury surrounding target chromophores (ie, blood vessels), initiating a wound repair process that ultimately leads to lesion regression.…”

Predicting Clinical Efficacy of Photoangiolytic and Cutting/Ablating Lasers using the Chick Chorioallantoic Membrane Model: Implications for Endoscopic Voice Surgery

“…Originally developed as a dermatologic laser for treatment of port wine stains, 1,31 the 585 nm PDL's clinical application has evolved to include treatment of mucosal diseases of the upper aerodigestive tract 3–5,6,8–10 . Rapid intravascular heating using high‐peak power (Watts) over very short pulse widths (0.45 ms for the initial PDLs) led to vessel damage associated with a variable rate of coagulation and rupture.…”

“…Photoangiolysis of the microcirculation within the layered microstructure (superficial lamina propria and epithelium) of the phonatory mucosa has been shown to be an effective strategy to treat a number of lesions including papillomatosis, [3][4][5][6][7] dysplasia, 8 -11 and microvascular angiomata. [12][13][14] Although the 532 nm wavelength of the KTP laser is slightly more absorbed by oxyhemoglobin than the 585 nm wavelength of the PDL (Fig.…”

Effects of 532 nm Pulsed‐KTP Laser Parameters on Vessel Ablation in the Avian Chorioallantoic Membrane: Implications for Vocal Fold Mucosa

“…It has become clear that photoangiolysis of the microcirculation of the superficial lamina propria is an effective strategy to treat a number of lesions of the phonatory mucosa, including papillomatosis, 10–14 dysplasia, 5,8,15,16 and microvascular angiomata 4,7,17 . The effectiveness of this approach in treating epithelial diseases in the operating room allowed for the creation of a new office‐based paradigm by using a 585‐nm PDL 5 and subsequently a 532‐nm pulsed KTP laser 8 through the operating channel of a flexible laryngoscope.…”