A new journey to predict the prognosis of diabetic kidney disease

Kim, Da Woon; Song, Sang Heon

doi:10.23876/j.krcp.23.093

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Diabetic nephropathy (DN) is the most common cause of chronic kidney disease (CKD) 1 , 2 , which is characterized by glomerulosclerosis and tubulointerstitial fibrosis, regardless of the cause 3 . At present, there is no specific treatment method for DN other than controlling glucose levels and blood pressure well before its onset.…”

Section: Introductionmentioning

confidence: 99%

Periostin deficiency attenuates kidney fibrosis in diabetic nephropathy by improving pancreatic β-cell dysfunction and reducing kidney EMT

Cho,

Jin,

Lee

et al. 2023

Sci Rep

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Diabetic nephropathy (DN) is associated with kidney fibrosis. A previous study revealed that periostin (POSTN) contributes to kidney fibrosis. This study examined the role of POSTN in DN. The urinary concentrations of POSTN and TNC increased according to the severity of DN in human samples. Streptozotocin (STZ) was administered after unilateral nephrectomy (UNXSTZ) to induce DN in wild-type and Postn-null mice. Four experimental groups were generated: wild-typeham (WT Sham), wild-type UNXSTZ (WT STZ), Postn-null Sham (KO Sham), and Postn-null UNXSTZ (KO STZ). After 20 weeks, the KO STZ group had lower levels of urine albumin excretion, glomerular sclerosis, and interstitial fibrosis than those of the WT STZ group. Additionally, the KO STZ group had lower expression of fibrosis markers, including TNC. The KO STZ group showed better glucose regulation than the WT STZ model. Furthermore, the KO STZ group exhibited significantly preserved pancreatic islet integrity and insulin expression. HK-2 cells were used to observe the aggravation of fibrosis caused by POSTN under TGF-β conditions. We stimulated INS-1 cells with streptozotocin and evaluated the viability of these cells. The anti-POSTN antibody treatment of INS-1 cells with streptozotocin resulted in higher cell viability than that with treatment with streptozotocin alone. The absence of POSTN in DN contributes to renal fibrosis alleviation by improving pancreatic β-cell function. Additionally, there is an association between POSTN and TNC.

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Section: Introductionmentioning

confidence: 99%