A new isoquinolone alkaloid from an endophytic fungus R22 of <i>Nerium indicum</i>

Ma, Yangmin; Qiao, Ke; Kong, Yang; Li, Mengyun; Guo, Linxin; Miao, Zhi Wei; Fan, Chunhai

doi:10.1080/14786419.2016.1258556

Cited by 30 publications

(21 citation statements)

References 16 publications

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“…Vancomycin treatment was associated with enrichment of pathways for isoquinoline compounds in both CDI and non-CDI stool samples; the enrichment of this pathway regardless of CDI status suggests that this observation represents an antibiotic-induced community function. These heterocyclic aromatic compounds are used in the production of antimicrobial agents ( 31 ), including antifungal agents ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Treatments for Clostridium difficile Infection Are Associated with Distinct Bacterial and Fungal Community Structures

Lamendella

Wright

Hackman

et al. 2018

mSphere

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Using human fecal samples and including sequencing for both bacterial and fungal taxa, this study compared the conventional antibiotics used to treat C. difficile infection (CDI) from the perspective of the microbiome, which is particularly relevant, given the relationship between dysbiotic states and the development of CDI. Sequencing and imputed functional analyses suggest that C. difficile-directed antibiotics are associated with distinct forms of dysbiosis that may be influential in the course of CDI. Further, a role for fungal organisms in the perpetuation of the causal dysbiosis of CDI is discussed, suggesting a previously unappreciated, clinically relevant transkingdom interaction that warrants further study.

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Section: Discussionmentioning

confidence: 99%

Antibiotic Treatments for Clostridium difficile Infection Are Associated with Distinct Bacterial and Fungal Community Structures

Lamendella

Wright

Hackman

et al. 2018

mSphere

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“…R22 associated with Nerium indicum collected from Qinling Mountain, Shaanxi Province, China was the source of 5-hydroxy-8-methoxy -4-phenylisoquinolin-1(2H)-one ( 145 ) a new isoquinolone alkaloid along with 3- O -methylviridicatin ( 146 ) and viridicatol ( 147 ) ( Figure 7 ) two known quinolinone alkaloids. Compound 145 exhibited good antifungal activity against Alternaria brassicae , A. alternata and Valsa mali with MIC value of 31.2 µg/mL, compound 146 against A. brassicae , B. cinerea and Valsa male with MIC value of 31.2 µg/mL, compound 147 against A. brassicae , A. alternata and B. cinerea with MIC value of 31.2 µg/mL [ 79 ].…”

Section: Medicinal Plantsmentioning

confidence: 99%

Endophytic Fungi: A Source of Potential Antifungal Compounds

Deshmukh

Gupta

Prakash

et al. 2018

JoF

107

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The emerging and reemerging forms of fungal infections encountered in the course of allogeneic bone marrow transplantations, cancer therapy, and organ transplants have necessitated the discovery of antifungal compounds with enhanced efficacy and better compatibility. A very limited number of antifungal compounds are in practice against the various forms of topical and systemic fungal infections. The trends of new antifungals being introduced into the market have remained insignificant while resistance towards the introduced drug has apparently increased, specifically in patients undergoing long-term treatment. Considering the immense potential of natural microbial products for the isolation and screening of novel antibiotics for different pharmaceutical applications as an alternative source has remained largely unexplored. Endophytes are one such microbial community that resides inside all plants without showing any symptoms with the promise of producing diverse bioactive molecules and novel metabolites which have application in medicine, agriculture, and industrial set ups. This review substantially covers the antifungal compounds, including volatile organic compounds, isolated from fungal endophytes of medicinal plants during 2013–2018. Some of the methods for the activation of silent biosynthetic genes are also covered. As such, the compounds described here possess diverse configurations which can be a step towards the development of new antifungal agents directly or precursor molecules after the required modification.

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“…#12 in >10-fold higher quantity than the ΔlaeA mutant, and pyripyropene O was putatively identified and produced in >2-fold higher quantity. Cyclopenol is an alkaloid that is described as a mycotoxin in the benzodiazepine class 70 and serves as an biosynthetic intermediate for viridicatol 71 , which has been described as having antibacterial activity against Staphylococcus aureus 72 . Small amounts of viridicatol were indeed found in extracts with high quantities of cyclopenol.…”

Section: Resultsmentioning

confidence: 99%

From iron to antibiotics: Identification of conserved bacterial-fungal interactions across diverse partners

Morin

et al. 2020

Preprint

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Microbial interactions are major determinants in shaping microbiome structure and function. Although fungi are found across diverse microbiomes, the mechanisms through which fungi interact with other species remain largely uncharacterized. In this work, we explore the diversity of ways in which fungi can impact bacteria by characterizing interaction mechanisms across 16 different bacterial-fungal pairs, involving 8 different fungi and 2 bacteria (Escherichia coli and Pseudomonas psychrophila). Using random barcode transposon-site sequencing (RB-TnSeq), we identified a large number of bacterial genes and pathways important in fungal interaction contexts. Within each interaction, fungal partners elicit both antagonistic and beneficial effects. Using a panel of phylogenetically diverse fungi allowed us to identify interactions that were conserved across all species. Our data show that all fungi modulate the availability of iron and biotin, suggesting that these may represent conserved bacterial-fungal interactions. Several fungi also appear to produce previously uncharacterized antibiotic compounds. Generating a mutant in a master regulator of fungal secondary metabolite production showed that fungal metabolites are key shapers of bacterial fitness profiles during interactions. This work demonstrates a diversity of mechanisms through which fungi are able to interact with bacterial species. In addition to many species-specific effects, there appear to be conserved interaction mechanisms which may be important across microbiomes.

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A new isoquinolone alkaloid from an endophytic fungus R22 of Nerium indicum

Cited by 30 publications

References 16 publications

Antibiotic Treatments for Clostridium difficile Infection Are Associated with Distinct Bacterial and Fungal Community Structures

Antibiotic Treatments for Clostridium difficile Infection Are Associated with Distinct Bacterial and Fungal Community Structures

Endophytic Fungi: A Source of Potential Antifungal Compounds

From iron to antibiotics: Identification of conserved bacterial-fungal interactions across diverse partners

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