A new isoflavonol and other constituents from Cameroonian propolis and evaluation of their anti-inflammatory, antifungal and antioxidant potential

Tamfu, Alfred Ngenge; Sawalda, Mathieu; Fotsing, Maurice Tagatsing; Toghueo, Rufin Marie Kouipou; Talla, Emmanuel; Fru, Godloves; Epanda, Justin Jacquin Epah; Mbafor, Joseph Tanyi; Baig, Tariq Ahmad; Jabeen, Almas; Shaheen, Farzana

doi:10.1016/j.sjbs.2019.11.035

Cited by 25 publications

(28 citation statements)

References 26 publications

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“…The good antioxidant activity observed for C. nepeta extracts corroborates previous studies [ 45 ]. Utilization and development of more effective antioxidants of natural medicinal plants are desired as these antioxidants are considered safer than synthetic ones [ 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition, Anti-Quorum Sensing, Enzyme Inhibitory, and Antioxidant Properties of Phenolic Extracts of Clinopodium nepeta L. Kuntze

Hatem

Boudiba

Benahmed

et al. 2021

Plants

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Phenolic extracts of Clinopodium nepeta were prepared and their preliminary phenolic profiles determined using HPLC-DAD with 26 phenolic standards. Apigenin (21.75 ± 0.41 µg/g), myricetin (72.58 ± 0.57 µg/g), and rosmarinic acid (88.51 ± 0.55 µg/g) were the most abundant compounds in DCM (dichloromethane), AcOEt (ethyl acetate), and BuOH (butanol) extracts, respectively. The DCM and AcOEt extracts inhibited quorum-sensing mediated violacein production by C. violaceum CV12472. Anti-quorum-sensing zones on C. violaceum CV026 at MIC (minimal inhibitory concentration) were 10.3 ± 0.8 mm for DCM extract and 12.0 ± 0.5 mm for AcOEt extract. Extracts showed concentration-dependent inhibition of swarming motility on flagellated P. aeruginosa PA01 and at the highest test concentration of 100 μg/mL, AcOEt (35.42 ± 1.00%) extract displayed the best activity. FRAP assay indicated that the BuOH extract (A0.50 = 17.42 ± 0.25 µg/mL) was more active than standard α-tocopherol (A0.50 = 34.93 ± 2.38 µg/mL). BuOH extract was more active than other extracts except in the ABTS●+, where the DCM extract was most active. This antioxidant activity could be attributed to the phenolic compounds detected. C. nepeta extracts showed moderate inhibition on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, and α-amylase. The results indicate that C. nepeta is a potent source of natural antioxidants that could be used in managing microbial resistance and Alzheimer′s disease.

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Section: Discussionmentioning

confidence: 99%

Chemical Composition, Anti-Quorum Sensing, Enzyme Inhibitory, and Antioxidant Properties of Phenolic Extracts of Clinopodium nepeta L. Kuntze

Hatem

Boudiba

Benahmed

et al. 2021

Plants

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“…Different studies have been carried out to determine in vitro the AOA of bee products using biological (cellular) systems. The more recent ones are summarized in Table 6 [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 32 , 33 , 34 , 47 , 74 , 118 , 142 , 161 , 165 , 180 ]. Cell lines of different types and origins have, in the main, been used for this purpose in all bee products.…”

Section: In Vitro Determination Of Aoamentioning

confidence: 99%

“…In vitro and in vivo studies are seldom used to quantify the AOA of bee products, with a wide variability in tests and results, which we will outline below. The antioxidant properties of bee products have been applied to biological systems in vitro and in vivo, e.g., on cell lines [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], blood cells [ 30 , 31 , 32 , 33 , 34 ], or in different types of diseases in animal models and humans [ 3 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity in Bee Products: A Review

2021

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Bee products have been used since ancient times both for their nutritional value and for a broad spectrum of therapeutic purposes. They are deemed to be a potential source of natural antioxidants that can counteract the effects of oxidative stress underlying the pathogenesis of many diseases. In view of the growing interest in using bioactive substances from natural sources to promote health and reduce the risk of developing certain illnesses, this review aims to update the current state of knowledge on the antioxidant capacity of bee products such as honey, pollen, propolis, beeswax, royal jelly and bee venom, and on the analytical methods used. The complex, variable composition of these products and the multitude of analytical methods used to study their antioxidant activities are responsible for the wide range of results reported by a plethora of available studies. This suggests the need to establish standardized methods to more efficiently evaluate the intrinsic antioxidant characteristics of these products and make the data obtained more comparable.

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“…Flavonoids are abundant in the leaves, flowers, and fruits of the plants [53,54] from which bees collect resins and sticky exudates to make their propolis. Triterpenoids are widely distributed in African propolis [15,16,55,57,58] but have also been reported in Bolivia [62,63], Brazil [61], Indonesia [28], and Thailand [67]. The most common triterpenes isolated from propolis are cycloartanes [15,28,58,[61][62][63].…”

Section: Composition Based On Geographical Originmentioning

confidence: 99%

The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets

et al. 2020

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The kinetoplastids are protozoa characterized by the presence of a distinctive organelle, called the kinetoplast, which contains a large amount of DNA (kinetoplast DNA (kDNA)) inside their single mitochondrion. Kinetoplastids of medical and veterinary importance include Trypanosoma spp. (the causative agents of human and animal African Trypanosomiasis and of Chagas disease) and Leishmania spp. (the causative agents of the various forms of leishmaniasis). These neglected diseases affect millions of people across the globe, but drug treatment is hampered by the challenges of toxicity and drug resistance, among others. Propolis (a natural product made by bees) and compounds isolated from it are now being investigated as novel treatments of kinetoplastid infections. The anti-kinetoplastid efficacy of propolis is probably a consequence of its reported activity against kinetoplastid parasites of bees. This article presents a review of the reported anti-kinetoplastid potential of propolis, highlighting its anti-kinetoplastid activity in vitro and in vivo regardless of geographical origin. The mode of action of propolis depends on the organism it is acting on and includes growth inhibition, immunomodulation, macrophage activation, perturbation of the cell membrane architecture, phospholipid disturbances, and mitochondrial targets. This gives ample scope for further investigations toward the rational development of sustainable anti-kinetoplastid drugs.

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A new isoflavonol and other constituents from Cameroonian propolis and evaluation of their anti-inflammatory, antifungal and antioxidant potential

Cited by 25 publications

References 26 publications

Chemical Composition, Anti-Quorum Sensing, Enzyme Inhibitory, and Antioxidant Properties of Phenolic Extracts of Clinopodium nepeta L. Kuntze

Chemical Composition, Anti-Quorum Sensing, Enzyme Inhibitory, and Antioxidant Properties of Phenolic Extracts of Clinopodium nepeta L. Kuntze

Antioxidant Activity in Bee Products: A Review

The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets

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