A New Isoflavone from Astragalus peregrinus

El-Latif, Rasha R. Abd; Shabana, Manal H.; El-Gandour, A. H.; Mansour, Ragaa M.A.; Sharaf, M.

doi:10.1023/b:conc.0000018105.23722.7d

Cited by 11 publications

(13 citation statements)

References 7 publications

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“…The biologically active sources of Astragalus species comprise polysaccharides, saponins, phenolics and the toxic compounds; such as nitrotoxins, imidazoline alkaloids and selenium derivatives (Pistelli 2002). However, researchers have mainly focused on the isolation and elucidation of cycloartane-type triterpenes (Polat et al 2010;Savran et al 2012), oleanane-type triterpenes (G€ ulcemal et al 2013), flavonoids (Benchadi et al 2013;Chaturvedula & Prakash 2013) and isoflavonoids (Zheng Zhong et al 1998;Abd El-latif et al 2003) from various Astragalus species.…”

Section: Introductionmentioning

confidence: 99%

Compounds from the pods of Astragalus armatus with antioxidant, anticholinesterase, antibacterial and phagocytic activities

Labed

Ferhat

Labed-Zouad

et al. 2016

Pharmaceutical Biology

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Context: The phytochemical study and biological activities of Astragalus armatus Willd. subsp. numidicus (Fabaceae) pods, an endemic shrub of Maghreb, are reported. Objective: This study isolates the secondary metabolites and determines the bioactivities of Astragalus armatus pods. Materials and methods: The chloroform, ethyl acetate and n-butanol extracts of hydro-ethanolic extracts were studied. Antioxidant activity was investigated using DPPH and ABTS radical scavenging, CUPRAC and ferrous chelating assays at concentrations ranging from 3 to 200 lg/mL. Anticholinesterase activity was determined against acetylcholinesterase and butyrylcholinesterase enzymes at 50, 100 and 200 lg/mL. Antibacterial activity was performed according to minimum inhibitory concentration (MIC) method. Carbon clearance method in albino mice was used for the phagocytic activity at concentrations 50, 70 and 100 mg/kg body weight. Spectroscopic techniques were used to elucidate the compounds. Results: Ethyl acetate extract afforded a flavonoid (1) while the n-butanol extract gave four flavonoids (2-5), a cyclitol (6) and a cycloartane-type saponin (7). The ethyl acetate extract exhibited highest antioxidant activity in DPPH (IC 50 : 67.90 ± 0.57 lg/mL), ABTS (IC 50 : 11.30 ± 0.09 lg/mL) and CUPRAC (A 0.50 : 50.60 ± 0.9 lg/mL) assays. The chloroform extract exhibited the best antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, each with 80 lg/mL MIC values. The nbutanol extract enhanced phagocytic activity. Discussion and conclusion:, pinitol (6) and cyclomacroside D (7) were isolated whereas 1, 2, 6 and 7 are reported for the first time from A. armatus.

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Section: Introductionmentioning

confidence: 99%

Compounds from the pods of Astragalus armatus with antioxidant, anticholinesterase, antibacterial and phagocytic activities

Labed

Ferhat

Labed-Zouad

et al. 2016

Pharmaceutical Biology

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“…58 The authors further report that the resonances of the B-ring protons of 3 0 -hydroxy-4 0methoxy-substituted isoflavones exhibit anomalous multiplicities and coupling constants in 1 H NMR spectra acquired in DMSOd 6 or CD 3 OD, which can be misinterpreted as evidence for 3 0 ,5 0di-O-substitution. In this context, the structure of an isoflavonoid published in 2003 as 7-hydroxy-3 0 ,5 0 -dimethoxyisoflavone (from Astragalus peregrinus) 59 should also be reexamined, as was suggested previously. 58 No such data were available for a second 3 0 ,5 0 -di-O-substituted isoflavone from Caragana sinica whose structure was given as 7,5 0 -dihydroxy-6,3 0 -dimethoxyisoflavone.…”

Section: Isoflavonesmentioning

confidence: 91%

Isoflavonoids of the Leguminosae

Veitch

2009

Nat. Prod. Rep.

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This account describes more than 145 new isoflavonoids published between 2005 and 2007 as constituents of the Leguminosae, commenting on their source, identification, biological activity, synthesis, and ecological or chemosystematic significance. New applications of hyphenated analytical techniques for the characterisation of Leguminosae isoflavonoids are also reviewed, together with advances in biosynthetic studies. A checklist of new compounds by species is given, and 170 references are cited.

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“…Just like many other herbs, Astragalus genus plants are also a rich source of flavonoids. The flavonoids in this genus include flavonols ( 162 – 182 ) [2,8,22,63,64,65,66,67,68], flavones ( 183 – 193 ) [2,8,53,63,66,69], flavonones ( 194 – 195 ) [65,70] and isoflavonoids ( 196 – 221 ) [16,50,53,65,66,70,71,72,73,74,75], which have many kinds of bioactivities.…”

Section: Phytochemistrymentioning

confidence: 99%

A Review of Recent Research Progress on the Astragalus Genus

Li¹,

Qu²,

Dong³

et al. 2014

Molecules

238

148

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Astragalus L., is one of the largest genuses of flowering plants in the Leguminosae family. Roots of A. membranaceus Bge. var. mongholicus (Bge.) Hsiao, A. membranaceus (Fisch.) Bge. and its processed products are listed in the China Pharmacopeia for "qi deficiency" syndrome treatment. However, more and more researches on other species of Astragalus have been conducted recently. We summarize the recent researches of Astragalus species in phytochemistry and pharmacology. More than 200 constituents, including saponins and flavonoids, obtained from 46 species of Astragalus genus were collected for this article. In pharmacological studies, crude extracts of Astragalus, as well as isolated constituents showed anti-inflammatory, immunostimulant, antioxidative, anti-cancer, antidiabetic, cardioprotective, hepatoprotective, and antiviral activities. The goal of this article is to provide an overview of chemical and pharmacological studies on the Astragalus species over the last 10 years, which could be of value to new drug or food supplement research and development. OPEN ACCESS

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A New Isoflavone from Astragalus peregrinus

Cited by 11 publications

References 7 publications

Compounds from the pods of Astragalus armatus with antioxidant, anticholinesterase, antibacterial and phagocytic activities

Compounds from the pods of Astragalus armatus with antioxidant, anticholinesterase, antibacterial and phagocytic activities

Isoflavonoids of the Leguminosae

A Review of Recent Research Progress on the Astragalus Genus

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