A new isocoumarin from mangrove endophytic fungus (No. dz17) on the South China Sea coast

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

“…091,402 exhibited moderate cytotoxicity potential towards K562 (IC 5018.9 µg/mL)[87]. Huang et al reported that 142 prohibited HepG2 and Hep-2 cells growth (IC 50 s 55 and 52 µg/mL, respectively) using MTT method[88]. The cytotoxic potential of 252 isolated Aspergillus versicolor was estimated towards A549, NB4, PC3, SHSY5Y, and MCF7.…”

“…The ability of compounds72, 188, 189, 202-205, 207-211, 231, 233, 234, 286, and 287 to regulate Nrf2, that complies to the oxidative stress by binding to ARE in the gene's coding promoter for antioxidant enzymes and protein for the synthesis of glutathione using ARE-driven luciferase reporters in HepG2C8 cells was evaluated. Compounds 209, 210, and 233 (a dose 10 µM) produced a significant induction of luciferase 1.93-2.95 folds more than DMSO (blank control), whereas tBHQ (positive control) invigorated the luciferase activation with 4 folds more than DMSO at a dose (50 µM)[65].Compounds 80,88,118,119, 303, and 307 isolated from Penicillium coffeae were tested for their DPPH scavenging activities. Only 302 had a moderate effect (IC 50 656 µM), compared to BHT (IC 50 59 µM), whereas the rest compounds had no activities (IC 50 > 900 µM)[47].…”

Chemistry and cytotoxic activities of polyketides produced by the mangrove endophytic fungus Phomopsis SP. ZSU-H76

“…In our search for new metabolites from marine-derived mangrove endophytic fungi from the South China Sea, we have isolated many significant new bioactive metabolites [2][3][4][5][6][7][8]. This paper reports the isolation and characterization of a new polyketide, 2-(7′-hydroxyoxooctyl)-3-hydroxy-5-methoxybenzeneacetic acid ethyl ester (1), and three known compounds dothiorelone A (2), B (3), and C (4) from the mangrove endophytic fungus Phomopsis sp.…”

Isolation, Characterization and Anti-Multiple Drug Resistant (MDR) Bacterial Activity of Endophytic Fungi Isolated from the Mangrove Plant, <i>Aegiceras corniculatum</i>

“…Some endophytes have proved to produce the same or similar chemical compounds as those obtained from their host with antibiotic, antiviral and anticancer activity [5][6]. Endophytes derived from mangrove plant have become interesting as significant resources for new chemicals in drug discovery [7][8][9]. Now, multiple-drug resistant (MDR) bacteria are a big public health problem in our world [10].…”