A new insight into the dissociating effect of strontium on bone resorption and formation

Braux, Julien; Velard, Frédéric; Guillaume, Christine; Bouthors, Sylvie; Jallot, Édouard; Nédélec, Jean-Marie; Laurent-Maquin, Dominique; Laquerrière, Patrice

doi:10.1016/j.actbio.2011.02.013

Cited by 144 publications

(115 citation statements)

References 47 publications

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“…Oral administration of Sr, as strontium ranelate (SrRan), has been shown to effectively reduce the risk of newly occurring fractures in postmenopausal women 21,22 as it affects both the bone-forming osteoblasts and bone-resorbing osteoclasts by interfering in cellular processes and apoptotic events. [23][24][25] The mechanisms through which Sr affects bone remodeling are not yet fully understood. However, a Sr-driven differentiation of human mesenchymal stem cells by activation of canonical and noncanonical Wnt signaling, 25,26 an inhibitory effect on osteoclast activity, 27 and an influence on differentiation of osteoclasts and osteoblasts have been observed.…”

Section: Introductionmentioning

confidence: 99%

Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats

Offermanns¹,

Oz²,

Riede³

et al. 2016

IJN

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Since strontium (Sr) is known for its anabolic and anticatabolic effect on bone, research has been focused on its potential impact on osseointegration. The objective of this study was to investigate the performance of nanotopographic implants with a Sr-functionalized titanium (Ti) coating (Ti–Sr–O) with respect to osseointegration in osteoporotic bone. The trial was designed to examine the effect of sustained-release characteristics of Sr in poor-quality bone. Three Ti–Sr–O groups, which differed from each other in coating thickness, Sr contents, and Sr release, were examined. These were prepared by a magnetron sputtering process and compared to uncoated grade 4 Ti. Composition, morphology, and mechanical stability of the coatings were analyzed, and Sr release data were gained from in vitro washout experiments. In vivo investigation was carried out in an osteoporotic rat model and analyzed histologically, 6 weeks and 12 weeks after implantation. Median values of bone-to-implant contact and new bone formation after 6 weeks were found to be 84.7% and 54.9% (best performing Sr group) as compared to 65.2% and 23.8% (grade 4 Ti reference), respectively. The 12-week observation period revealed 84.3% and 56.5% (best performing Sr group) and 81.3% and 39.4% (grade 4 Ti reference), respectively, for the same measurements. The increase in new bone formation was found to correlate with the amount of Sr released in vitro. The results indicate that sputtered nanostructured Ti–Sr–O coatings showed sustained release of Sr and accelerate osseointegration even in poor-quality bone, and thus, may have impact on practical applications for medical implants.

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Section: Introductionmentioning

confidence: 99%

Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats

Offermanns¹,

Oz²,

Riede³

et al. 2016

IJN

View full text Add to dashboard Cite

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“…Sr increases osteoblast replication, differentiation, and bone matrix mineralization relying on calcium sensing receptor dependent mechanism [3][4][5]. Previous studies incorporated Sr into calcium phosphate coatings or bioactive glasses to stimulate the bone formation [6][7][8][9].…”

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confidence: 99%

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

et al. 2016

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An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloyIn: Acta Biomaterialia (2015) Elsevier DOI: 10.1016DOI: 10. /j.actbio.2015 An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloy AbstractPrevious studies indicated that local delivery of strontium effectively increased bone quality and formation around osseointegrating implants. Therefore, implant materials with long-lasting and controllable strontium release are avidly pursued. The central objective of the present study was to investigate the in vivo biocompatibility, metabolism and osteogenic activity of the bioabsorbable Mg-1Sr (wt.%, nominal composition) alloy for bone regeneration. The general corrosion rate of the alloy implant as a femoral fracture fixation device was 0.55 ± 0.03 mm y −1 (mean value ± standard deviation) in New Zealand White rabbits which meet the bone implantation requirements and can be adjusted by material processing methods. All rabbits survived and the histological evaluation showed no abnormal physiology or diseases 16 weeks post-implantation. The degradation process of the alloy did not significantly alter 16 primary indexes of hematology, cardiac damage, inflammation, hepatic functions and metabolic process. Significant increases in peri-implant bone volume and direct bone-toimplant contact (48.3% ± 15.3% and 15.9% ± 5.6%, respectively) as well as the expressions of four osteogenesis related genes (runt-related transcription factor 2, alkaline phosphatase, osteocalcin, and collagen, type I, alpha 1) were observed after 16 weeks implantation for the Mg-1Sr group when compared to the pure Mg group. The sound osteogenic properties of the Mg-1Sr alloy by longlasting and controllable Sr release suggesting a very attractive clinical potential. Statement of significanceSr (strontium) has exhibited pronounced effects to reduce the bone fracture risk in osteoporotic patients. Nonetheless, long-lasting local Sr release is hardly achieved by traditional methods like surface treatment. Therefore, a more efficient Sr local delivery platform is in high clinical demand. The stable and adjustable degradation process of Mg alloy makes it an ideal Sr delivery platform. We combine the well-known osteogenic properties of strontium with magnesium to manufacture bioabsorbable Mg-1Sr alloy with stable Sr release based on our previous studies. The in vitro and in vivo results both showed the alloy's suitable degradation rate and biocompatibility, and the sound osteogenic properties and stimulation effect on bone formation suggest its very attractive clinical potential.

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“…On the other hand, Sr can reduce the osteoclast differentiation and resorbing activity. Sr has also been recently reported to direct the MSCs' commitment to the bone lineage (Peng et al, 2009;Braux et al, 2011;Yang et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Adhesion of bone marrow mesenchymal stem cells on porous titanium surfaces with strontium-doped hydroxyapatite coating

Jiang

et al. 2017

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To determine the adhesion behavior of bone marrow mesenchymal stem cells (MSCs) on a titanium surface with a nanostructured strontium-doped hydroxyapatite (Sr-HA) coating. Methods: Sr-HA coatings were applied on roughened titanium surfaces using an electrochemical deposition method. Primary cultured rat MSCs were seeded onto Sr-HA-, HA-coated titanium, and roughened titanium surfaces, and they were then cultured for 1, 6, and 24 h. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the metabolic condition of the cells. Scanning electron microscopy (SEM) was used to observe the cell morphology. The cytoskeletal structure was analyzed using fluorescence actin staining to characterize cell adherence. Quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) was used to analyze the gene expression levels of FAK (focal adhesion kinase), vinculin, integrin β1, and integrin β3 after culturing for 24, 48, and 72 h. Results: MSCs cultured on the Sr-HA surface showed better cell proliferation and viability. Improvement of cell adhesion and structural rearrangement of the cytoskeleton were observed on the Sr-HA surface. The gene expression of FAK, vinculin, integrin β1, and integrin β3 was also elevated on the Sr-HA surface. Conclusions: Cell viability, adhesion, cell morphology, and the cytoskeletal structure were all upregulated considerably by the titanium surface modified with a Sr-HA coating.

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A new insight into the dissociating effect of strontium on bone resorption and formation

Cited by 144 publications

References 47 publications

Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats

Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

Adhesion of bone marrow mesenchymal stem cells on porous titanium surfaces with strontium-doped hydroxyapatite coating

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