A new insertion sequence element containing a cfiA gene in the first imipenem-resistant Bacteroides fragilis strain isolated in Italy

Cascio, Giuliana Lo; Macaccaro, Laura; Centonze, Anna Rita; Sóki, Jozsef; Fontana, Roberta; Mazzariol, Annarita

doi:10.1016/j.ijantimicag.2009.08.001

Cited by 1 publication

(1 citation statement)

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“…However, there were numerous batch studies that reported this kind of resistance to several strains in France, Japan, USA, Hungary, Kuwait, all over Europe, Korea, Denmark, and Turkey [2,[12][13][14][15][16][17]. Several other studies reported unique strains that were isolated separately [18,19]. For these latter strains, we also know the clinical backgrounds that were often critical to the patients harboring them.…”

Section: Discussionmentioning

confidence: 96%

The first characterized carbapenem-resistant Bacteroides fragilis strain from Croatia and the case study for it

Bogdan

Perić

Ördög

et al. 2018

AMicr

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An imipenem-resistant Bacteroides fragilis strain was isolated from the blood of a 72-year-old male patient with a urinary bladder tumor in Osijek, Croatia. This strain was also resistant to ampicillin, piperacillin/tazobactam, cefoxitin, clindamycin, tetracycline, and harbored cfiA, ermF, and tetQ genes where the high-level expression of the cfiA carbapenem-resistant gene was driven by an IS1187 element. Interestingly, despite the carbapenem-resistant feature of the B. fragilis from blood, the patient relatively easily recovered from the bacteremia. It was the first characterized imipenem-resistant B. fragilis isolate with its case report from Croatia, which confirmed the appearance of carbapenem-resistant B. fragilis strains, that continues worldwide with low incidence and the molecular characteristics vary temporally and geographically.

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