A New Inorganic Photolabile Protecting Group for Highly Efficient Visible Light GABA Uncaging

Zayat, Leonardo; Noval, María G.; Campi, Julieta; Calero, Cecilia I.; Calvo, Daniel J.; Etchenique, Roberto

doi:10.1002/cbic.200700354

Cited by 92 publications

(91 citation statements)

References 24 publications

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“…The design of RuBi-GABA [18] and RuBiGlutamate [20] opened a wide spectrum of possibilities to experiment with 1P and 2P active caged versions of the most ubiquitous inhibitory and excitatory neurotransmitters. RuBi-Glutamate appears to be a superb tool to determine circuitry in dense neuronal systems [28][29][30][31][32].…”

Section: Applications Of Ru-bpy Complexes In Neurophysiologymentioning

confidence: 99%

Ruthenium polypyridyl phototriggers: from beginnings to perspectives

Zayat

Filevich

Baraldo

et al. 2013

Phil. Trans. R. Soc. A.

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104

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Octahedral Ru(II) polypyridyl complexes constitute a superb platform to devise photoactive triggers capable of delivering entire molecules in a reliable, fast, efficient and clean way. Ruthenium coordination chemistry opens the way to caging a wide range of molecules, such as amino acids, nucleotides, neurotransmitters, fluorescent probes and genetic inducers. Contrary to other phototriggers, these Ru-based caged compounds are active with visible light, and can be photolysed even at 532 nm (green), enabling the use of simple and inexpensive equipment. These compounds are also active in the two-photon regime, a property that extends their scope to systems where IR light must be used to achieve high precision and penetrability. The state of the art and the future of ruthenium polypyridyl phototriggers are discussed, and several new applications are presented.

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Section: Applications Of Ru-bpy Complexes In Neurophysiologymentioning

confidence: 99%

Ruthenium polypyridyl phototriggers: from beginnings to perspectives

Zayat

Filevich

Baraldo

et al. 2013

Phil. Trans. R. Soc. A.

Self Cite

104

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“…These compounds are able to releases, with high yields, one of the monodentate ligands and were all, except the pyridine derivative, prepared by Etchenique and co-workers for the photorelease of neuroactive small molecules, i.e. 4-aminopyridine, butylamine and γ -aminobutyric acid [97][98][99].…”

Section: Photochemical Ligand Substitution In Ru Polypyridyl Complexesmentioning

confidence: 99%

The photochemistry of transition metal complexes using density functional theory

Garino

Salassa

2013

Phil. Trans. R. Soc. A.

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The use of density functional theory (DFT) and timedependent DFT (TD-DFT) to study the photochemistry of metal complexes is becoming increasingly important among chemists. Computational methods provide unique information on the electronic nature of excited states and their atomic structure, integrating spectroscopy observations on transient species and excited-state dynamics. In this contribution, we present an overview on photochemically active transition metal complexes investigated by DFT. In particular, we discuss a representative range of systems studied up to now, which include CO-and NO-releasing inorganic and organometallic complexes, haem and haem-like complexes dissociating small diatomic molecules, photoactive anti-cancer Pt and Ru complexes, Ru polypyridyls and diphosphino Pt derivatives.

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“…Visible light-sensitive inorganic cages using a ruthenium complex (ruthenium bipyridines) as a photosensor for visible light (16,17) have been recently developed for both GABA (RuBiGABA) (18) and glutamate (RuBiGlutamate) (16) with no apparent toxicity and with faster dynamics than organic approaches. In the present study, we demonstrate for the first time that the photorelease of RuBiGABA-PMe 3 , a modified version of RuBiGABA, with a visible light pulse successfully suppresses cortical local field potential (LFP) activity in anesthetized animals with high temporal resolution.…”

Section: Introductionmentioning

confidence: 99%