A new indanedione derivative alleviates symptoms of diabetes by modulating RAGE-NF-kappaB pathway in db/db mice

Khan, Gulnaz; Aftab, Meha Fatima; Bano, Bilquees; Khan, Khalid Mohammed; Murtaza, Munazza; Siddiqui, S.; Rehman, Mujeeb; Waraich, Rizwana Sanaullah

doi:10.1016/j.bbrc.2018.05.043

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…Endothelial damage also contributes to thickening of the vascular wall, impairs vasodilation, and results in vessel stiffening [ 63 ]. The presence of AGEs promotes the activity of the endothelial receptor for advanced glycation end products (RAGE), which contributes to ROS production [ 64 ]. Endothelial oxidative stress in DM also derives from Ras-related C3 botulinum toxin substrate 1 (RAC1) and T cell lymphoma invasion and metastasis (TIAM1)-dependent activation of NOX2 [ 65 ] and diacylglycerol (DAG)/protein kinase C (PKC)-dependent phosphorylation and stimulation of the NOX activator p47phox [ 66 ].…”

Section: Endothelial Cell Dysfunctionmentioning

confidence: 99%

Diabetes and Thrombosis: A Central Role for Vascular Oxidative Stress

et al. 2021

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Diabetes mellitus is the fifth most common cause of death worldwide. Due to its chronic nature, diabetes is a debilitating disease for the patient and a relevant cost for the national health system. Type 2 diabetes mellitus is the most common form of diabetes mellitus (90% of cases) and is characteristically multifactorial, with both genetic and environmental causes. Diabetes patients display a significant increase in the risk of developing cardiovascular disease compared to the rest of the population. This is associated with increased blood clotting, which results in circulatory complications and vascular damage. Platelets are circulating cells within the vascular system that contribute to hemostasis. Their increased tendency to activate and form thrombi has been observed in diabetes mellitus patients (i.e., platelet hyperactivity). The oxidative damage of platelets and the function of pro-oxidant enzymes such as the NADPH oxidases appear central to diabetes-dependent platelet hyperactivity. In addition to platelet hyperactivity, endothelial cell damage and alterations of the coagulation response also participate in the vascular damage associated with diabetes. Here, we present an updated interpretation of the molecular mechanisms underlying vascular damage in diabetes, including current therapeutic options for its control.

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Section: Endothelial Cell Dysfunctionmentioning

confidence: 99%

Diabetes and Thrombosis: A Central Role for Vascular Oxidative Stress

et al. 2021

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“…2-Arylidenindane-1,3-diones are an important class of chemicals with many potential applications ranging from material to medical science. Some derivatives show antibacterial activities and nonlinear optical properties, and some have been used as electroluminescent devices, eye lens clarification agents, urease and protease inhibitors, and anticoagulant agents and alleviate symptoms of diabetes. − They can be also considered as organic Lewis acids. , Because of their low-lying lower unoccupied molecular orbitals, they are reactive Michael acceptors and have been used as heterodienes in cycloaddition reactions. , …”

Section: Introductionmentioning

confidence: 99%

“…5,6 Because of their low-lying lower unoccupied molecular orbitals, they are reactive Michael acceptors and have been used as heterodienes in cycloaddition reactions. 7,8 Synthesis of 2-arylideneindane-1,3-diones through condensation reaction of indan-1,3-dione with aromatic aldehydes using piperidinein in organic solvents, 8 pyridine, 2 and aqueous sodium hydroxide 9 has been reported. In addition, various amino acids and amines have been employed for synthesis of 2arylidenindane-1,3-diones starting from aromatic aldehydes and indan-1,3-dione.…”

Section: ■ Introductionmentioning

confidence: 99%

Green and Fast Synthesis of 2-Arylidene-indan-1,3-diones Using a Task-Specific Ionic Liquid

et al. 2020

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A novel method for condensation reaction of indan-1,3-dione with various aldehydes which are efficiently catalyzed by a task-specific ionic liquid, 2-hydroxyethylammonium formate, to provide the corresponding 2-arylidenindane-1,3-diones has been developed. This green, low-cost, high-yield, and fast reaction takes place at room temperature without the use of any solvent and catalyst. A plausible reaction mechanism that involves ionic liquidassisted activation is also discussed. This work is the first report of ionic liquids as a reaction medium and catalyst for the synthesis of 2-arylidenindane-1,3-diones.

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