“…In line with this, Maddaloni et al (2018) showed that 5-HT depleted Tph2 mutant mice present an innate behavior resembling mania, which was reversed by mood stabilizer treatment (valproic acid) ( Maddaloni et al, 2018 ). Also, Azechi et al (2019) reported that Fawn-Hooded (FH) rats that carry dysfunctional gene mutations in the serotonergic system presented hyperactivity and high impulsivity behavior followed by low hippocampal 5-HT levels and increased 5-HT metabolization rate ( Azechi et al, 2019 ). On the other hand, the results obtained with our drug protocols revealed that DOXY had few effects against AMPH-induced 5-HT changes.…”