A new in vitro fertilization technique: Intravaginal culture

Ranoux, C; Aubriot, FX; Dubuisson, JB

doi:10.1016/0020-7292(89)90510-9

Cited by 7 publications

(11 citation statements)

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“…The INVO procedure consists of utilizing the vaginal cavity environment for the oocyte fertilization and embryo development. 2 We assessed this procedure using the INVOcell device and evaluated the PR, IR, and MRs. Our data showed that the formation of normal zygotes and good quality embryos after microinjection is possible, as well as good clinical outcomes. The INVOcell device can be inserted transiently in the vagina for up to 3 or 5 days without bleeding or any clinical impact or endometrial receptivity.…”

Section: Discussionmentioning

confidence: 99%

“…Ranoux et al 2 developed an intravaginal culture system named INVO (intravaginal culture of oocytes). They proposed a simplified alternative option to conventional IVF.…”

Section: Introductionmentioning

confidence: 99%

“…They proposed a simplified alternative option to conventional IVF. 2 The INVO procedure is simple, requires minimal laboratory equipment, and has a low cost, utilizing the vaginal cavity environment for oocyte fertilization and incubation of early embryo development. The vaginal cavity provides the pCO 2 , pO 2 , and temperature for the culture of the gametes and embryos.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, INVO procedures have been performed in several countries such as Austria, Bolivia, Brazil, Ecuador, India, Mexico, Nicaragua, Pakistan, Panama, Spain, Turkey, and Venezuela with pregnancy rates (PRs) ranging from 19.6% to 31%. 2,[5][6][7][8] In the conventional IVF procedure, the oocytes are inseminated with a total of 50,000-100,000 spermatozoa with fertilization and cleavage rates of 80% and 95% respectively. In the INVO procedure, the inner chamber of the INVOcell has a volume of 1.08 mL, and there the oocytes are inseminated with a maximum of 30,000 spermatozoa to avoid the risk of polyspermic embryos; however, this reduced spermatozoa concentration in high culture media volume results in low percentages of cleaved embryos at day 3 (30%-60%).…”

Section: Introductionmentioning

confidence: 99%

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In Vivo Culture System Using the INVOcell Device Shows Similar Pregnancy and Implantation Rates to those Obtained from in Vivo Culture System in ICSI Procedures

García-Ferreyra¹,

Hilario

Luna³

et al. 2015

Clin Med�Insights�Reprod�Health

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CAPSULEClinical outcomes using INVOcell device with ICSI.OBJECTIVEIntravaginal culture of oocytes (INVO) procedure is an intravaginal culture system that utilizes the INVOcell device in which the fertilization and embryo culture occur. In this procedure, the vaginal cavity serves as an incubator for oocyte fertilization and early embryonic development. The objective of this study was to evaluate the clinical outcomes of this intravaginal culture system in intracytoplasmic sperm injection (ICSI).METHODSA total of 24 cycles INVO-ICSI (study group) and 74 cycles of ICSI (control group) were included in the study. The cleaved oocytes at day 3/total injected oocytes, embryo quality, pregnancy rate (PR), implantation rate (IR), and miscarriage rate (MR) were compared between both groups.RESULTSAt day 3, there was no difference in the cleaved oocyte rate (78.7 and 76.1%) and embryo quality (77 and 86.8%) for the study and control groups, respectively. In the study group, more embryos were significantly transferred compared to the control group (2.63 ± 0.58 versus 1.93 ± 0.25; P < 0.05). PRs, IRs, and MRs were similar for the study group compared with the control group (PR: 54.2% versus 58.1%; IR: 31.7% versus 33.6%; MR: 7.7% versus 20.9%).CONCLUSIONSGood PR and IR can be obtained using the INVOcell device, and the INVO-ICSI procedure can be considered as an alternative option to infertile patients.

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Section: Discussionmentioning

confidence: 99%

“…Ranoux et al 2 developed an intravaginal culture system named INVO (intravaginal culture of oocytes). They proposed a simplified alternative option to conventional IVF.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In Vivo Culture System Using the INVOcell Device Shows Similar Pregnancy and Implantation Rates to those Obtained from in Vivo Culture System in ICSI Procedures

García-Ferreyra¹,

Hilario

Luna³

et al. 2015

Clin Med�Insights�Reprod�Health

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“…According to publications of technical studies related to IVC clinical pregnancy rates ranging from 19.6% to 31%. (Ranoux, 1988 and1990;Bonaventura. Et al.2006).…”

Section: Introductionmentioning

confidence: 99%

Introduction of the method of intravaginal culture (IVC), through the device InVOCell routine laboratory RHA in Brazil

Coelho¹,

Aguiar²,

Cunha³

et al. 2013

JBRA Assisted Reproduction

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A pilot study to evaluate a device for the intravaginal culture of embryos

Mitri

Esfandiari

Coogan-Prewer

et al. 2015

Reproductive BioMedicine Online

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The aim of this comparative randomized embryology trial was to determine if an intravaginal culture device (IVC) can provide acceptable embryo development compared with conventional IVF. Ten women between the ages of 27 and 37 years with an indication for IVF treatment were included in this study. After ovarian stimulation, oocytes were randomized to fertilization in the IVC device or using conventional IVF. Fertilization rates were higher in the IVF group compared with the IVC device (68.7% ± 36 % versus 40.7% ± 27%), respectively, whereas cleavage rates were similar (93% ± 1.5% versus 97% ± 6%) for both groups. A significantly lower number of embryos of suitable quality for transfer was obtained from the IVC device compared with conventional IVF (OR, 0.47; 95% CI, 0.26 to 0.87). The clinical pregnancy rate from transfer of IVC device embryos was 30%. Satisfaction questionnaires were also completed by all participants. Most women (70%) placed high importance on having had fertilization and embryo development occur while carrying the device. Overall, the IVC device produced reasonable pregnancy rates suggesting this technology may have a place under certain circumstances. Cost-benefit analysis, psychological factors and future studies must be considered.

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A new in vitro fertilization technique: Intravaginal culture

Cited by 7 publications

References 0 publications

In Vivo Culture System Using the INVOcell Device Shows Similar Pregnancy and Implantation Rates to those Obtained from in Vivo Culture System in ICSI Procedures

In Vivo Culture System Using the INVOcell Device Shows Similar Pregnancy and Implantation Rates to those Obtained from in Vivo Culture System in ICSI Procedures

Introduction of the method of intravaginal culture (IVC), through the device InVOCell routine laboratory RHA in Brazil

A pilot study to evaluate a device for the intravaginal culture of embryos

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