A new implant with solid core and porous surface: The biocompatability with bone

Abstract

This research investigated osteogenic potencies of Farthing-Fray-Chen Titanium (FFcTi) implant with transitional porous-solid structure. The material characteristics, biomechanical property, osteogenic performances were assessed. FFcTi showed similar roughness as sand-blasted and acid etched titanium (SA), but was more hydrophilic than SA and machined commercial pure titanium (MA). Young's modulus of FFcTi implant in compressive tests was 15.8 ± 6.3 GPa, which was close to bone. In vitro observations manifested excellent spreading abilities of MC3T3-E1 cell on FFcTi and SA. Adhesion rates of MC3T3-E1 cells at 4 h gradually decreased on MA, SA, and FFcTi surfaces (MA > SA, p < 0.01; SA > FFcTi, p < 0.05), while cell proliferation ability on FFcTi was weaker than MA during 1-6 days (p < 0.01) and similar to MA and SA in day 11. ALP activity of cells on FFcTi at 14 day was higher than MA and lower than SA (p < 0.01). In a bone defect model of rabbits, BIC and bone volum ratio within 50 μm were significantly higher for FFcTi than MA (BIC, p < 0.01; BT0.05, p < 0.05) while bone volume ratio within 100 and 500 μm were of no differences. Micro CT analysis also showed similar results to the histomorphometric data. Thus, we conclude that FFcTi with melting sphere based multiporous structure has a hydrophilic, rough surface, and close modulus to bone. In vitro, its low proliferation and ALP activity promotion were similar to other micro scale roughed surface. In vivo test showed better osteogenesis ability when compared with MA at least in 2 weeks. Thus, this Farthing-Fray-Chen Titanium implant seems to hold considerable potential for bone implant applications.

Electrochemical Preparation of Porous Ti–13Zr–13Nb Alloy and It's Corrosion Behavior in Ringer's Solution

“…Although the detailed sintering mechanism is still unclear, the contribution from Zr and/or Nb is further supported by current work. The special heritage phenomenon encourages the manufacturing of the medical implant directly from an oxide preform 14) with desirable size, shape and surface structure. The surface morphology and porosity of the material will absolutely affect its mechanical strength and its compatibility with bone and bio-organisms 14) .…”

“…The special heritage phenomenon encourages the manufacturing of the medical implant directly from an oxide preform 14) with desirable size, shape and surface structure. The surface morphology and porosity of the material will absolutely affect its mechanical strength and its compatibility with bone and bio-organisms 14) . Therefore, the surface morphology of the obtained TZN alloy was further characterized by SEM (Fig.…”

“…Besides pure Ti, Ti alloys including TiNi, TiFeNi, TiW, TiZr have already been prepared in a similar approach [10][11][12][13] . It was found that the obtained metal/alloys had a porous matrix consisting of interconnected homogeneous nodular metallic particles, which could be due to their porous oxide precursor 14,15) . Moreover, the porosity, oxygen content and phase composition of the obtained metal/alloys can be easily controlled by electrolysis conditions such as temperature, cell voltage and electrolysis time.…”

Design and Mechanical Compatibility of Nylon Bionic Cancellous Bone Fabricated by Selective Laser Sintering

“…When under loading, the prosthesis was too hard to bear more load, and the surrounding host bone did not have enough load to bear and was shielded by stress. Eventually, this would lead to the bone’s resorption and loosening and the offset of implantation and even fractures [ 10 ]. At present, the stress shielding effect that leads to osteoporosis is a difficult problem for biomaterials.…”

Evaluation of antibacterial, angiogenic, and osteogenic activities of green synthesized gap-bridging copper-doped nanocomposite coatings

“…47,48 In this study, we investigated the biocompatibility of Cu-CSG coatings using BMSCs, which is an important cell source in bone tissue engineering. Cell proliferation tests revealed that all Cu-doped coatings were favorable for the cell proliferation except Cu IV group ( Figure 10B).…”