A new imaging entity consistent with partial ectopic posterior pituitary gland: report of six cases

Ybarra, Marina; Hafiz, Rawan; Robinson, Marie-Ève; Oettingen, Julia E. Von; Bui, Helen; Saint‐Martin, Christine

doi:10.1007/s00247-019-04502-5

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…Phenotypes of these mutations are variable and affect patients in different ways. Some patients had only pituitary hormone deficiencies in their adulthood (18). All our patients could reach their estimated height when they became adults.…”

Section: Discussionmentioning

confidence: 78%

Patients with Ectopic Posterior Pituitary: Report of 6 Patients

Özışık¹,

Yürekli²,

Kitiş³

et al. 2021

Turk J Endocrinol Metab

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Objective: Ectopic posterior pituitary (EPP) can occur because of a migration defect or neurodegeneration of the hypothalamic nuclei. EPP is typically rarely diagnosed. Therefore, we aimed to report our patients with EPP. Material and Methods: This is a retrospective study (approved by the Ege University Ethical Committee, protocol 20-7T/49) that included 6 patients with EPP who were followed up between 2012 and 2019. We collected information on age, sex, height, weight, body mass index, age at the diagnosis, history of traumatic delivery, consanguinity, multiple hormone deficiency and treatment. We examined laboratory levels and medical records, and, magnetic resonance imaging (MRI) reports. Results: The mean age of patients was 25.83 years, and the age at diagnosis was 11.16 years. One patient was female, and the others were male. They were receiving hormone replacement treatment. The patients were diagnosed with EPP during their childhood. All patients, except 2, were taking growth hormone replacement therapy. Only one patient had a history of consanguinity. Additional information about the patients is described in the patient sections. Conclusion: Patients with EPP are rarely seen, and this rare condition should be considered when a patient has panhypopituitarism. MRI is the gold standard imaging modality for hypophysis to identify this condition. In addition, patients who have EPP in MRI should be screened for hypopituitarism.

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Section: Discussionmentioning

confidence: 78%

Patients with Ectopic Posterior Pituitary: Report of 6 Patients

Özışık¹,

Yürekli²,

Kitiş³

et al. 2021

Turk J Endocrinol Metab

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“…However, in the last decades, PSIS has been widened to include patients with one feature such as ectopic posterior pituitary, or interrupted stalk, or interrupted pituitary stalk with absent posterior pituitary 115,118 . Rarely, double or partial ectopic posterior pituitary could be documented [114][115][116]119,136 (Figure 2). PSIS remains a complex etiology involving several factors (epigenetics, environment, drugs and genetics).…”

Section: [H2] Mri Findings In Hypopituitarismmentioning

confidence: 99%

Advances in differential diagnosis and management of growth hormone deficiency in children

et al. 2021

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Growth hormone (GH) deficiency (GHD) in children is defined as impaired production of GH by the pituitary gland that results in growth failure. This disease may be congenital or acquired, and occurs in isolation or in the setting of multiple pituitary hormone deficiency (MPHD). Isolated GHD has an estimated prevalence of 1 patient per 4,000-10,000 livebirths and can be due to multiple causes, some of which are yet to be determined. Establishing the correct diagnosis remains key in children with short stature, as initiating treatment with recombinant human GH can help them attain their genetically determined adult height. During the past 2 decadesour understanding of the benefits of continuing GH throughout the transition period from childhood to adulthood has increased. Improvements in transitional care will help alleviate the consequent physical and psychological problems that can arise from adult GHD, although the consequences of lack of hormone replacement are less severe in adults than in childhood. In this manuscript, we review the differential diagnosis in children with GHD, including details of clinical presentation, neuroimaging, and genetic testing. Furthermore, we highlight advances and issues in management of GHD, including details of transitional care.

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