A New Human Blood Group

Cutbush, Marie; Mollison, P. L.; Parkin, Dorothy M.

doi:10.1038/165188b0

Cited by 160 publications

(52 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5) or U(0,1). With the log-based prior distribution, we re-estimate the initial frequency at 0.15% (95% CI: 0.018-0.77%; Fig 4 in S1 Appendix), closely fitting our inference.…”

Section: Inference Of T Mrca Of Fy*o and Fy*amentioning

confidence: 99%

See 1 more Smart Citation

Population Genetic Analysis of the DARC Locus (Duffy) Reveals Adaptation from Standing Variation Associated with Malaria Resistance in Humans

McManus

Taravella

Henn

et al. 2016

Preprint

View full text Add to dashboard Cite

The human DARC (Duffy antigen receptor for chemokines) gene encodes a membranebound chemokine receptor crucial for the infection of red blood cells by Plasmodium vivax, a major causative agent of malaria. Of the three major allelic classes segregating in human populations, the FY*O allele has been shown to protect against P. vivax infection and is at near fixation in sub-Saharan Africa, while FY*B and FY*A are common in Europe and Asia, respectively. Due to the combination of strong geographic differentiation and association with malaria resistance, DARC is considered a canonical example of positive selection in humans. Despite this, details of the timing and mode of selection at DARC remain poorly understood. Here, we use sequencing data from over 1,000 individuals in twenty-one human populations, as well as ancient human genomes, to perform a fine-scale investigation of the evolutionary history of DARC. We estimate the time to most recent common ancestor (T MRCA ) of the most common FY*O haplotype to be 42 kya (95% CI: 34-49 kya). We infer the FY*O null mutation swept to fixation in Africa from standing variation with very low initial frequency (0.1%) and a selection coefficient of 0.043 (95% CI:0.011-0.18), which is among the strongest estimated in the human genome. We estimate the T MRCA of the FY*A mutation in non-Africans to be 57 kya (95% CI: 48-65 kya) and infer that, prior to the sweep of FY*O, all three alleles were segregating in Africa, as highly diverged populations from Asia and 6 ¼Khomani San hunter-gatherers share the same FY*A haplotypes. We test multiple models of admixture that may account for this observation and reject recent Asian or European admixture as the cause.

show abstract

“…5) or U(0,1). With the log-based prior distribution, we re-estimate the initial frequency at 0.15% (95% CI: 0.018-0.77%; Fig 4 in S1 Appendix), closely fitting our inference.…”

Section: Inference Of T Mrca Of Fy*o and Fy*amentioning

confidence: 99%

“…The DARC gene has three major allelic types that are the product of two common polymorphisms, forming the basis of the Duffy blood group system [5,6]. The two variant forms, FY Ã B and FY Ã A, are the allelic types commonly observed in non-African populations.…”

Section: Introductionmentioning

confidence: 99%

Population Genetic Analysis of the DARC Locus (Duffy) Reveals Adaptation from Standing Variation Associated with Malaria Resistance in Humans

McManus

Taravella

Henn

et al. 2016

Preprint

View full text Add to dashboard Cite

show abstract

“…observed in connection with the Rh-Hr, Duffy, Kell, and Kidd antigens in man (24)(25)(26)(27), and with the A antigen in dogs (12), and such antibodies have been referred to variously as "univalent," "incomplete," "blocking," and "hyperimmune" antibodies. That the coating anti-G and anti-g antibodies herein described are specific antibodies is demonstrated by a number of facts: firstly, such antibodies coated only those cells that were agglutinated by their corresponding agglutinating antibodies; secondly, the antibodies could be eluted from the cells by heating them in saline at 56°C., and the eluate was then capable of coating fresh cells; and thirdly, the antibodies agglutinated trypsin-treated cells containing the corresponding antigen in about the same titer as their coating effect on the same cells, without trypsin treatment, could be demonstrated by means of the Coombs test.…”

Section: Heat Stability Of Anti-g Serummentioning

confidence: 99%

Experimental Erythroblastosis Fetalis in Rabbits

Kellner

Hedal

1953

Journal of Experimental Medicine

View full text Add to dashboard Cite

A pair of blood group factors, designated G and g, was identified in rabbits by serological means. These factors were found to be alleles, and one or the other or both of them were regularly present in the red cells of every one of a large number of mongrel and inbred rabbits. The factors were not demonstrable in other tissue cells or in the body fluids. They were capable of stimulating the formation of specific immune isoantibodies when repeatedly injected into appropriate rabbits. In most instance both agglutinating and coating antibodies to the G or g factors were present in a given antiserum. The coating antibodies-which did not act as true blocking antibodies-were detected by means of an antiglobulin test (Coombs test), or by means of specific cells modified by the action of trypsin. The antibodies were heat-stable and were active over a wide temperature range; and under suitable conditions, they proved to be potent hemolysins and also capable of fixing complement. The characteristics of the antigens and antibodies of the rabbit G-g system bear a striking resemblance to those of the Rh-Hr system of man.

show abstract

“…The Duffy blood group antigen system was originally described in 1950 based on discovery of an alloantibody against an antigen denoted as Fy(a) in a patient with hemophilia who had received multiple transfusions (Cutbush et al, 1950). The Duffy antigen system consists of multimeric erythrocytic membrane surface proteins composed of different subunits in which glycoprotein D is the major subunit that carries the antigenic determinants as defined by anti-Fy(a), anti-Fy(b) antibodies (Tournamille et al, 1997).…”

Section: Duffy Blood Group Antigen On Erythrocytesmentioning

confidence: 99%