A new HLA-B44 subtype, B*4406, differing in exon 2

Yao, Zhu; Lattermann, A.; Volgger, A.; McNicholas, A.; Mueller‐Eckhardt, G.; Albert, E. D.

doi:10.1007/bf00163999

Cited by 12 publications

(2 citation statements)

References 7 publications

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“…Seven HLA-B44 subtypes (Bodmer et al, 1995) have now been identified by DNA sequencing: B*4402 (Parham et al, 1988); B*44031 (Fleischhauer et al, 1991), B*44032 (Adams et al, 1995), B*4404 (Gauchat-Feiss et al, 1994;Yao et al, 1995a), B*4405 (Yao et al, 1994), B*4406 (Yao et al, 1995b;Zhao et al, 1996), and very recently B*4407, sequenced from an Equatorian Guinean individual (Vilches et al, 1996). Except for B*4406, which is a mixed allele with the α1 domain of B*51 and α2 domain of B*4402 (Yao et al, 1995b;Zhao et al, 1996), they differ in four amino acid positions (residues 41, 116, 156 and 163) in the α1/α2 domains.…”

Section: Introductionmentioning

confidence: 99%

Hla‐b44 Allele Frequencies and Haplotypic Associations in Three European Populations

Vidan-Jeras¹,

Breur-Vriesendorp²,

Bohinjec³

et al. 1997

European Journal of Immunogenetics

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HLA-B44 is among the most frequent class I antigens in many populations studied so far. It has been subdivided into seven allelic forms that can only be discriminated by DNA typing. Using a simple PCR/sequence-specific oligonucleotide hybridization procedure, we have analysed the frequency distribution of B44 subtypes in three European populations from Slovenia, the Netherlands, and Switzerland. B*4402 and B*4403 were by far the predominant alleles, B*4404 and 4405 were rare, while B*4406 and B*4407 were not observed. Interestingly, B*4402 and 4403 occurred with different frequencies in the three populations, with B*4402 being most frequent in the Swiss (65% vs. 57% in the Dutch, and 46.5% in the Slovenes). Of the 139 individuals studied, 60 HLA-B44 ABDR haplotypes could be determined by family studies. In the respective populations, the linkage disequilibria between B44 and other HLA antigens occurred with different frequencies. A2-B*4402 haplotypes were very frequent in the Swiss sample, mostly associated with DRB1*0101, 0401 and 1301. B*4402 was more often linked with non-A2 antigens in the Slovenes (predominantly A24, A28) than in the Swiss and the Dutch. The predominant association of B*4403 was with DR7: this haplotype was very frequent in the Swiss (82% of the B*4403 haplotypes), while lower frequencies were found in the Dutch (72%) and Slovenian (59%) populations. In the Swiss population, more than half of the B44-DR7 haplotypes were A23-B*4403-DR7 (53% of all B*4403 haplotypes). This haplotype was significantly less frequent in the Slovenian (6%) and in the Dutch (14%) populations. The second most frequent B*4403 haplotype in both the Swiss and Slovenes is the A29-B*4403-CW*1601-DR7 haplotype (17.6 and 29.4%, respectively). Concomitant with the increased frequency of B*4403 in the Slovenes, a higher diversity of non-DR7 B44 haplotypes was observed in this population (41% of all B*4403 haplotypes). HLA-B44 oligotyping analysis allowed us to detect B44-subtype incompatibilities in several AB-sero, DRB1/B3/B5-oligo matched unrelated bone marrow donor/patient combinations. The different frequency distributions of HLA-B44 haplotypes in the three populations analysed in this study argue in favour of local volunteer bone marrow donor recruitment. This might significantly improve the chance of finding a highly matched donor for patients with less frequent A-B-DRB1 haplotypes.

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Section: Introductionmentioning

confidence: 99%

Hla‐b44 Allele Frequencies and Haplotypic Associations in Three European Populations

Vidan-Jeras¹,

Breur-Vriesendorp²,

Bohinjec³

et al. 1997

European Journal of Immunogenetics

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“…Polymorphisms in the third exon define B*4402, B*44031, B*44032 (5) , B*4404 (6) and edge of the haplotypic relationships involving B-44 subtypes may therefore have important clinical implications. B*4405 (7), whereas the subtypes B*4406 (8) and B*4407 (9) show nucleotide substitutions in the second exon. B*4402 and B*4403 (corresponding to IEF-defined 44.2 and 44.1 alleles, respectively (10)) are the most frequent subtypes in Caucasians and differ only at position 156 with a non-conservative substitution.…”

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confidence: 98%

HLA‐B44 subtypes and the chance of finding HLA compatible donor/recipient pairs for bone marrow transplantation: a haplotype study of 303 Italian families

et al. 1997

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A total of 1176 HLA-A,B,DR haplotypes were reconstructed by typing 303 unrelated families referred to our laboratory during the last seven years for the search of HLA identical sibs in view of bone marrow transplantation. A total of 614 different three-locus haplotypes were found. Most of them (83.6%) were present only once or twice, whereas 24/614 (3.9%) were found 6-28 times each. HLA-B44 was present in 4 of these most frequent haplotypes. HLA-B44 has been implicated as the molecular target for bone marrow allograft rejection. Therefore, a better knowledge of the HLA-B44 haplotype relationships might prove useful for the programming of registries of unrelated bone marrow donors. Eighty five serologically defined HLA-B44 unrelated subjects, either one or both parents from the above families, were subtyped by a high-resolution sequence-specific oligonucleotide probing approach. Moreover, 34 unrelated potential donors recruited for those patients that did not find a suitable donor among their siblings were subtyped also for HLA-B44. B*4403, which accounted for 47/85 (55.3%) serologically defined B44 alleles, appeared in strong, statistically significant, linkage disequilibrium with HLA-A29, -A23 and -DR7. On the other hand, B*4402, which covered virtually all other B44 alleles, showed prevalent gametic associations with HLA-A2 and HLA-A24. The linkage disequilibrium between HLA alleles is the key for the low frequency of HLA-B44 mismatches in donors selected as HLA-A,B,DRB1 identical to patients waiting for unrelated bone marrow transplantation. If a given patient presents unusual haplotypes, the chance of finding HLA-B44 mismatches may be higher because of the presence of different haplotype relationships in the donors.

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A tyrosinase nonapeptide presented by HLA‐B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes

et al. 1996

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The human tyrosinase gene has been reported previously to code for two distinct antigens recognized on HLA-A2 melanoma cells by autologous cytolytic T lymphocytes (CTL). By stimulating lymphocytes of melanoma patient MZ2 with a subclone of the tumor cell line of this patient, we obtained a CTL clone that lysed this subclone but did not lyse other subclones of the same melanoma cell line. The sensitive melanoma subclone was found to express a much higher level of tyrosinase than the others, suggesting that the antigen recognized by the CTL might be encoded by tyrosinase. Transfection of a tyrosinase cDNA demonstrated that the CTL clone indeed recognized a tyrosinase product presented by HLA-B*4403. The relevant antigenic peptide corresponds to residues 192-200 of the tyrosinase protein. Lymphoblastoid cells of the B*4402 subtype were not recognized by the CTL following incubation with the peptide. Nevertheless, by stimulating in vitro lymphocytes of a healthy HLA-B*4402 donor with autologous adherent cells pulsed with the same peptide, we obtained a CTL clone which recognized tumor cells expressing tyrosinase and HLA-B*4402. As HLA-B44 is expressed in 24% of Caucasians, the tyrosinase-B44 antigen may constitute a useful target for specific immunotherapy of melanoma.

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A new HLA-B44 subtype, B*4406, differing in exon 2

Cited by 12 publications

References 7 publications

Hla‐b44 Allele Frequencies and Haplotypic Associations in Three European Populations

Hla‐b44 Allele Frequencies and Haplotypic Associations in Three European Populations

HLA‐B44 subtypes and the chance of finding HLA compatible donor/recipient pairs for bone marrow transplantation: a haplotype study of 303 Italian families

A tyrosinase nonapeptide presented by HLA‐B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes

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