A new hierarchical approach to multi-level model abstraction for simplifying ODE models of biological networks and a case study: The G1/S Checkpoint/DNA damage signalling pathways of mammalian cell cycle

Lenvatinib resistance mechanism and potential ways to conquer

“…Guo Y et al ( Guo et al, 2021a ) concluded that ATR-CHK1 signaling would be a therapeutic target for liver cancer. As reported, the role of ATR-CHK1 has been considered as a necessary regulator of the DDR, which especially involved in sensing DNA replication stress ( Smith et al, 2020 ; Khazaaleh et al, 2021 ; Vazhappilly et al, 2021 ). Further, this signal could activate oncogene and regulate G1 checkpoint ( Khazaaleh et al, 2021 ).…”

“…As reported, the role of ATR-CHK1 has been considered as a necessary regulator of the DDR, which especially involved in sensing DNA replication stress ( Smith et al, 2020 ; Khazaaleh et al, 2021 ; Vazhappilly et al, 2021 ). Further, this signal could activate oncogene and regulate G1 checkpoint ( Khazaaleh et al, 2021 ). Until now, the inhibitor of ATR and CHK1 exhibited good therapeutic effect on tumor in labortary, while the strategy on clinic still recommended the combination therapy of them.…”

Analysis on Intelligent Agent based Approach for Software Engineering

“…Cazzola, Ghosh, Al-Refai, and Maurina in [5]; Tsagkani and Tsalgatidou in [6]; and Khazaaleh, Samarasinghe, and Kulasiri in [7] Organization An activity involving the articulation and management of connections among diverse elements of problem-solving. Included in this category are phenomena like subroutines and inheritance (in objectoriented architectures) (in procedural languages).…”

“…Spanish Iberdrola, a renewable energy company, created and released this application (the enabling agent technology is described in further depth in [14], and further information about its use in this area is available in [7]). Energy management, in its broadest sense, is keeping tabs on and managing the process through which electrical energy is created, transmitted, and distributed to commercial and residential consumers.…”