A new herbicidal site of action: Cinmethylin binds to acyl-ACP thioesterase and inhibits plant fatty acid biosynthesis

Campe, Ruth; Hollenbach, Eva; Kämmerer, Lara; Hendriks, Janneke; Höffken, Hans Wolfgang; Kraus, Helmut; Lerchl, Jens; Mietzner, Thomas; Tresch, Stefan; Witschel, Matthias; Hutzler, Johannes

doi:10.1016/j.pestbp.2018.04.006

Cited by 66 publications

(143 citation statements)

References 34 publications

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“…First, it was clarified that the site of action of the herbicide cinmethylin, whose registration has expired (in Japan), is fatty acid thioesterase (FAT). 88) The second herbicide is cyclopyrimorate. It has been reported that the site of action of this new herbicide, discovered by Mitsui Chemicals Agro and registered in Japan in September 2019, is the homogentisate solanesyltransferase (HST).…”

Section: After 2018mentioning

confidence: 99%

“…It has recently been revealed by BASF scientists that cinmethylin binds to fatty acid thioesterase (FTA), a new herbicidal site of action, and inhibits plant fatty acid biosynthesis. 88) BASF has recently developed cinmethylin (Luximax, trade name: Luximo TM) ) as an herbicide to control key grasses in cereals. It demonstrates excellent efficacy against blackgrass and ryegrass, including resistant biotypes, while maintaining crop selec-…”

Section: Vlcfae Inhibitorsmentioning

confidence: 99%

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Development of novel pesticides in the 21st century

2020

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General trends and strategies for novel pesticides are summarized. Global pesticide sales and pesticide discovery research are also briefly reviewed. At least 105 chemical pesticides have been launched during the past decade or are under development: 43 fungicides, 34 insecticides/acaricides, 6 nematicides, 21 herbicides, and 1 herbicide safener. Most of them are safe to humans and environmentally friendly. The most developed fungicides are SDHI (succinate dehydrogenase inhibitors), DMI (demethylation inhibitors), QoI (quinone outside inhibitors), and QiI (quinone inside inhibitors). Due to the development of resistance to fungicides with existing modes of action, many fungicides possessing various novel modes of action have been launched or are under development. The trend of insecticide development is changing from organophosphorus, carbamate, and synthetic pyrethroids to nicotinic and diamide insecticides. During the past decade, compounds possessing a variety of novel modes of action have also been launched or are under development. Flupyradifurone and flupyrimin, exhibiting extremely low honeybee toxicity, have been developed and subjected to practical use. Herbicides possessing varied modes of action, such as acetolactate synthase, p-hydroxyphenylpyruvate dioxygenase, protoporphyrinogen oxidase, and very-long-chain fatty acid elongase inhibition, have been developed, but no herbicides possessing a novel mode action have commercialized in nearly 30 years. It is of interest that cyclopyrimorate, which was recently launched, and tetflupyrolimet, which is under development, have novel modes action: homogentisate solanesyltransferase (HST) and dihydroorotate dehydrogenase (DHODH) inhibition, respectively. The development of useful acaricides and nematicides is also progressing. Some natural product origin pesticides are getting attention.

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Section: After 2018mentioning

confidence: 99%

Section: Vlcfae Inhibitorsmentioning

confidence: 99%

Development of novel pesticides in the 21st century

2020

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“…Discovery of the MOA of an old herbicide cannot be considered as the entry of a new MOA into the market, but knowing the MOA may help with herbicide resistance management. Examples of the discovery of MOAs for older herbicides are the finding that endothall is a serine/threonine protein phosphatase inhibitor and that cinmethylin inhibits fatty acid thioesterases . Herbicides with truly new MOAs are badly needed for herbicide resistance management.…”

Section: Introductionmentioning

confidence: 99%

A novel genomic approach to herbicide and herbicide mode of action discovery

Duke

Stidham²,

Dayan

2018

Pest Management Science

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A herbicide with a new mode of action has not been commercialized for more than 30 years. A recent paper describes a novel genomic approach to herbicide and herbicide mode of action discovery. Analysis of a microbial gene cluster revealed that it encodes genes for both the biosynthetic pathway for production of the sesquiterpene aspterric acid and an aspterric acid-resistant form of dihydroxy acid dehydratase (DHAD), its target enzyme. Aspterric acid is weak compared with commercial synthetic herbicides, and whether DHAD is a good herbicide target is unclear from this study. Nevertheless, this genomic approach provides a novel strategy for the discovery of herbicides with new modes action.

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“…Also, cinmethylin targets the protein extracts of Lemna paucicostata Hegelm. that bind and validate FAT (fatty acid thioesterase) inhibition as a new site of action, different from other lipid biosynthesis inhibitors [23].Besides, researchers have been exploiting the processes of isolating new bioactive compounds from higher plants, especially from medicinal plants [24]. However, several novel bioactive substances that can lead to the identification of new herbicide sites of action that remain untapped in medicinal plants [25].…”

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Evaluation of Potential Volatile Allelopathic Plants from Bangladesh, with Sapindus mukorossi as a Candidate Species

et al. 2019

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This study focuses on identifying volatile emissions from plants with potential plant growth inhibitory activity. The aim of this study was to evaluate plant species from the Asian country Bangladesh for new, potential volatile allelopathic species. A total of 103 plant samples from 40 different families were assessed with the dish pack (DP) method. About 25% of the evaluated plant samples influenced (inhibited or stimulated) the growth of lettuce, due to the presence of potentially volatile allelochemicals. The pericarp of Sapindus mukorossi Gaertn. caused the lowest radicle elongation (3% of control) of the lettuce. This was followed by the leaves of Cassia nodosa Roxb. (34.4%) and the root of Kaempferia galangal L. (43.4%), in that order. Therefore, the pericarp of S. mukorossi is reported from this study as a new potential volatile allelopathic species. On the contrary, the leaves of Gynostemma pentaphyllum Thunb. had a stimulatory effect on the hypocotyl elongation of lettuce seedlings (156% of control). The single petri dish (SPD), a new method, was also adapted to justify the potentiality of the growth control of particular allelopathic species. This study revealed that the new potentially volatile allelopathic plant species could be further explored in sustainable weed management.Agronomy 2020, 10, 49 2 of 16 cyclones, extreme temperature increase, flooding, and drought could reduce rice and wheat production by 8% and 32%, respectively, when compared to yield in the 1990s [2].In recent years, improved and health-conscious crop protection technologies, coupled with high food demand with limited arable land, have become an indispensable concern in Bangladesh. Protection of field crops from weeds, diseases, and other crop pests are part of the critical factors for sustainable crop production. Weed management strategy plays a vital role and directly influences food security and productivity worldwide. Studies in 2006 and 2015 reported that about 34% of yield loss occurred due to the interference of weeds compared to other pests [3,4]. Rice is the major food in Bangladesh and mostly cultivated all over the country [5]. Mamun [6] reported that weeds reduced the yield of rice productivity in the range of 68%-100% for Aus rice, 16%-48% in Aman rice, and 22%-36% in Boro rice. Weeds compete directly with the crops for space, nutrition, light, and moisture. Hence, the physiological activity and growth of crop plants are significantly affected by weed interference [4,7].In managing weed interference, the extensive use of synthetic herbicides have led to the emergence of herbicide resistant/tolerant weeds [8]. Currently, there are about 256 weed species that have developed resistance to different herbicide sites of action [9]. Consequently, there is the need to diversify the herbicide application practices or identify new herbicide sites of action. The natural process of releasing bioactive secondary metabolites from organisms (plants, microbes, insects, fungus, algae), and the subsequent interaction with another orga...

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A new herbicidal site of action: Cinmethylin binds to acyl-ACP thioesterase and inhibits plant fatty acid biosynthesis

Cited by 66 publications

References 34 publications

Development of novel pesticides in the 21st century

Development of novel pesticides in the 21st century

A novel genomic approach to herbicide and herbicide mode of action discovery

Evaluation of Potential Volatile Allelopathic Plants from Bangladesh, with Sapindus mukorossi as a Candidate Species

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