A New Heavy Silicone Oil (Hws 46-3000) Used as a Prolonged Internal Tamponade Agent in Complicated Vitreoretinal Surgery

Rizzo, Stanislao; Genovesi-Ebert, Federica; Vento, Andrea; Cresti, Federica; Bartolo, Emanuele Di; Belting, Claudia

doi:10.1097/01.iae.0000251228.33870.64

Cited by 46 publications

(67 citation statements)

References 37 publications

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“…54 HWS 46-3000 is the latest, heaviest and most viscous of the three new tamponades; a clinically significant emulsification could not be observed in the first clinical application of HWS 46-3000 when left in situ for 1-3 months and the initial report with low complication and high success rates are encouraging. 22 However, the higher viscosity also increases the difficulties associated with the handling of the substance, for example, its removal. 22 …”

Section: Heavy Silicone Oilsmentioning

confidence: 99%

“…20,27 Oxane HD is the lightest of the three new tamponadesFthis might be one of the reasons why slightly higher redetachment rates could be noticed with this substance, when comparing the overall outcomes with other tamponades 21 ( Table 1) as well as individual series with different tamponades conducted within the same institution. 18,22,32 Especially in eyes with previous scleral buckling surgery, relatively light tamponades do not seem to enable an efficient tamponade in the area central to the indent. 19,32 Densiron 68 (Fluoron Co, Neu-Ulm, Germany) is a solution of perfluorohexyloctane (F6H8) and 5000 cSt silicone oil.…”

Section: Heavy Silicone Oilsmentioning

confidence: 99%

“…The 'next generation' 22 of heavy tamponades currently consists of three different prefabricated mixturesFOxane HD, Densiron 68, and HWS 46-3000. The substances differ in their silicone oil and PFA components, resulting in different specific gravities and viscosities of the products (Table 2).…”

Section: Heavy Silicone Oilsmentioning

confidence: 99%

“…18,19 Following the relative disappointment with these early heavy tamponades, we now seem to have entered a phase in which we might see the introduction of these vitreous substitutes into routine clinical use. Three recently developed heavy tamponades, Oxane HD, Densiron 68 and HWS 46-3000, have demonstrated better results and fewer complications compared to the earlier used substances, [20][21][22] and are now slowly gaining acceptance within the vitreoretinal community, [23][24][25][26][27] despite notable scepticism. In this article, the previous and current heavy tamponades, their indications, and the associated complications are reviewed.…”

Section: Introductionmentioning

confidence: 99%

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Heavy tamponade 1: a review of indications, use, and complications

Heimann

Stappler

Wong

2008

Eye

116

125

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Background Heavier than water intraocular tamponades have several theoretical advantages over conventional tamponades, especially in the treatment of complicated retinal detachments and proliferative viteroretinopathy of the lower fundus periphery. However, initial clinical series of various heavy tamponades have reported significant complication rates. Therefore, heavy tamponades have not found widespread acceptance. Three recently developed heavy silicone oil tamponades, Oxane HD, Densiron 68, and HWS 46-3000, are much better tolerated and presently seem to enter routine clinical practice. Materials and methods Literature review of 21 publications on the clinical application of 9 different heavy tamponades (fluorosilicone, C10F18, F6H8, OL62HV, Oxane HD, O62, F6H8-silicone oil mixture, Densiron 68, and HWS 46-3000). Results The first generation (fluorinated silicone and perfluorocarbon liquids) and second generation (partially fluorinated alkanes) of heavy tamponades were associated with relatively high complication rates, for example, tamponade emulsification, intraocular inflammation, and rise in intraocular pressure. The complication spectrum of the new generation of heavy silicone oils (Oxane HD, Densiron 68, and HWS 46-3000) seems to be comparable to conventional silicone oil tamponades while providing better support for the inferior retina and the posterior pole. Conclusion The recently developed heavy silicone oil tamponades are safe and effective tools for the use of complicated retinal detachments of the inferior fundus.

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Section: Heavy Silicone Oilsmentioning

confidence: 99%

Section: Heavy Silicone Oilsmentioning

confidence: 99%

Section: Heavy Silicone Oilsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Heavy tamponade 1: a review of indications, use, and complications

Heimann

Stappler

Wong

2008

Eye

116

125

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“…Recent studies have shown good anatomical and visual outcomes with no emulsification upto 3 months with these agents. [28][29][30] HSO works well as a long-term tamponade agent for complex retinal detachments involving inferior proliferative vitreoretinopathy. 31 …”

Section: Heavy Silicone Oilmentioning

confidence: 99%

Vitreous Substitutes

Azad¹

2012

DJO

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Current Situation and Challenges in Vitreous Substitutes

García

Bandín-Vilar

García-Quintanilla

et al. 2021

Macromolecular Bioscience

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Vitreo‐retinal disorders constitute a significant portion of treatable ocular diseases. These pathologies often require vitreo‐retinal surgery and, as a consequence, the use of vitreous substitutes. Nowadays, the vitreous substitutes that are used in clinical practice are mainly divided into gases (air, SF6, C2F6, C3F8) and liquids (perfluorocarbon liquids, silicone oils, and heavy silicone oils). There are specific advantages and drawbacks to each of these, which determine their clinical indications. However, developing the ideal biomaterial for vitreous substitution continues to be one of the most important challenges in ophthalmology, and a multidisciplinary approach is required. In this sense, recent research has focused on the development of biocompatible, biodegradable, and injectable hydrogels (natural, synthetic, and smart), which also act as medium and long‐term internal tamponade agents. This comprehensive review aims to cover the main characteristics and indications for use of the extensive range of vitreous substitutes that are currently used in clinical practice, before going on to describe the hydrogels that have been developed recently and which have emerged as promising biomaterials for vitreous substitution.

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A New Heavy Silicone Oil (Hws 46-3000) Used as a Prolonged Internal Tamponade Agent in Complicated Vitreoretinal Surgery

Abstract: HWS 46-3000 was well tolerated, effective in the inferior quadrants with a low incidence of membrane development. The main complication was the high rate of tamponade-related cataract formation.

Cited by 46 publications

References 37 publications

Heavy tamponade 1: a review of indications, use, and complications

Heavy tamponade 1: a review of indications, use, and complications

Vitreous Substitutes

Current Situation and Challenges in Vitreous Substitutes

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