A new havanensin-type limonoid from Chisocheton macrophyllus

Abstract

A new havanensin-type limonoid, 16β-hydroxydysobinin (1), along with four known limonoids (2–5), have been isolated from the seeds of Chisocheton macrophyllus. The chemical structure of the new compound was determined by referencing spectroscopic data, and by comparison to those related spectra previously reported. Each compound was evaluated for their cytotoxic effects against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and display no significant activity.

Nimonol from Chisocheton macrophyllus (Meliaceae) Seeds and Their Cytotoxic Activity against P-388 Leukaemia Cells

“…In a previous study of the Chisocheton genus, the highest number of limonoids and triterpenoids were found (Shilpi et al, 2016;Najmuldeen et al, 2012;Supratman et al, 2020;Nurlelasari et al, 2021;Nurlelasari et al, 2015), then steroid, phenolic (Hidayat et al, 2018) and spermidine alkaloids (Nguyen et al, 2020).…”

“…This plant has 53 species distributed in tropical and subtropical forests such as Asia, Malaysia, and Indonesia (Shilpi et al, 2016). Chisocheton compounds have been widely reported to have a variety of activities, such as antimalarial (Nurlelasari et al, 2016), antimicrobials (Nurlelasari et al, 2021;Fitriana et al, 2021;Nurlelasari et al, 2020;Rahmayanti et al, 2021), antifeedant, growth regulator, repellent, larvacide (Nurlelasari et al, 2017;Lin et al, 2021;Lin et al, 2022), antitumor (Rahmayanti et al, 2021;Cahn et al, 2012;Najmuldeen et al, 2012) and anti-inflammatory (Yang et al, 2012) and cytotoxic activity (Nurlelasari et al, 2016;Badria & Ahmed., 2018;Katja et al, 2016;Nurlelasari et al, 2021).…”

Antidiabetic, cytotoxic and antioxidant activities of Rhodomyrtus tomentosa leaf extracts

“…The in vitro cytotoxic assay against the human cervix adenocarcinoma (HeLa), human breast adenocarcinoma (MCF-7), human lung carcinoma (A549), and murine melanoma (B16) cancer cell lines was performed using the PrestoBlue (PB) method. 16 The cells were preserved with a complete RPMI medium containing 50 μL/50 mL antibiotics and 10% (v/v) FBS. Cell cultures with a density of 170 000 cells per mL of medium were then incubated in 96 well plates at 37 °C for 24 hours in 5% CO 2 .…”

Biological Activity Evaluation and In Silico Studies of Polyprenylated Benzophenones from Garcinia celebica

“…The in vitro cytotoxic assay against the HeLa (human cervix adenocarcinoma), MCF-7 (human breast adenocarcinoma), A549 (human lung carcinoma), and B16 (murine melanoma) cancer cell lines was performed using the PrestoBlue (PB) Assay with minor modification [ 32 ]. For this assay, the cells were preserved with a complete RPMI medium containing 10% ( v/v ) FBS and 50 μL/50 mL antibiotics.…”