A New Halimane Diterpenoid from Croton crassifolius

Zhang, Zhan‐Xin; Li, Hui-Hong; Qi, Feng‐Ming; Xiong, Huan; Dong, Le-Le; Fan, Gai-Xia; Fei, Dong‐Qing

doi:10.5012/bkcs.2014.35.5.1556

Cited by 19 publications

(13 citation statements)

References 16 publications

(10 reference statements)

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“…This journal is © The Royal Society of Chemistry 2018 The study of genus Halimium plants has made possible to determine the presence of ve chemotypes of Halimiun viscosum, known in accordance with the harvesting place: Villarino de los Aires, (Salamanca, Spain), 17 La Fregeneda, (Salamanca, Spain), 26,27 Valparaiso, (Zamora, Spain), 28 Celorico da Beira, (Portugal) 29 and San João da Pesqueira, (Portugal). 30 In this group, the Euphorbiaceae, 78,108,109,[111][112][113][114] Cistaceae, 17,26,27,29,30,110,[115][116][117][118] Leguminoseae, 48,119,120 Compositae, 21,24 Jungermanniaceae, 121 Velloziaceae 52 and Annonaceae 122,123 plant families have been studied together with marine organisms of genus Spurilla 124 and Agelas. 74,125 The most numerous compounds of this group (Fig.…”

Section: Scheme 10mentioning

confidence: 99%

“…These functionalizations are most frequent in the ent-halim-5(10)-enes, as we will explain later. Crassifoliusin A (63) 113 and crassin D (64), 114 isolated from Croton crassifolius, have a tricyclic system formed by cyclization of C1 with C12 of the halimane side chain.…”

Section: Scheme 10mentioning

confidence: 99%

“…8, Table S2 †). Compounds of this type have been isolated from plants of the families Euphorbiaceae, 44,78,105,107,109,[111][112][113][114][136][137][138][139][140][141][142][143][144][145][146][147][148][149][150][151] Compositae, 45 Annonaceae, 122 Lamiaceae, 91 Jungermanniaceae, 152,153 Asteraceae, 76 and Meliaceae, 154 and in sponges of genus Agelas. 79,135 Among them, chettaphanin II (102) 111 is found.…”

Section: Halim-5(10)-enes Groupmentioning

confidence: 99%

“…Functionalization at C7 is seen in compounds 128, 134 and 140 and at C8 only on compound 140. 76 Crassifolin A (112), crassifolin B (113), and penduli-aworosin (126) showed anti-angiogenic activity using a wildtype zebrash in vivo model, 44,78 and crassifolin D (114) shows antiviral and anti-angiogenic activities. 44 Crolaevinoids A-B (128-129) and crothalimene A (130) were recently isolated from Croton laevigatus and Croton dichogamus, respectively.…”

Section: Halim-5(10)-enes Groupmentioning

confidence: 99%

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Halimane diterpenoids: sources, structures, nomenclature and biological activities

et al. 2018

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Covering: 1970 to 2017 Diterpenes with a halimane skeleton constitute a small group of natural products that can be biogenetically considered as being between labdane and clerodane diterpenoids. Some of these compounds show biological activities, such as antitumour, mosquito repellency, germination inhibition and antimicrobial, as well as being biomarkers for tuberculosis. To the best of our knowledge, there are no reviews on these compounds. In this review, halimane skeleton diterpenoids are classified according to their biogenetic origin, characterization and/or the enzymes involved in their biosynthesis. Herein, a review of their synthesis or synthetic approaches is communicated.

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Section: Scheme 10mentioning

confidence: 99%

Section: Scheme 10mentioning

confidence: 99%

Section: Halim-5(10)-enes Groupmentioning

confidence: 99%

Section: Halim-5(10)-enes Groupmentioning

confidence: 99%

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Halimane diterpenoids: sources, structures, nomenclature and biological activities

et al. 2018

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“…Two halimane-type diterpenoids, chettaphanins I and II (442 and 443), were isolated from Adenochlaena siammensis (Euphorbiaceae) (Sato et al 1970(Sato et al , 1971. Later, a new halimane-type diterpenoid, crassifoliusin A (444), was isolated from Croton crassifolius (Euphorbiaceae) (Zhang et al 2014).…”

Section: Miscellaneous Structures (Type Vii)mentioning

confidence: 99%

Naturally occurring furanoditerpenoids: distribution, chemistry and their pharmacological activities

et al. 2016

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Furanoditerpenoids are a special group of diterpenoids composing of one or more furan rings, which are rarely found in nature. This review aims to survey the various naturally occurring furanoditerpenoids and their pharmacological activities. A fairly large number of furanoditerpenoids have been reported from the families Euphorbiaceae, Fabaceae and Lamiaceae, and a few ones from the families Asteraceae, Codoniaceae, Dioscoreaceae, Fossombroniaceae, Jamesoniellaceae, Meliaceae, Menispermaceae, Olacaceae, Psathyrellaceae, Sapindaceae and Scapaniaceae. Their distribution correlates strongly with the taxonomic divisions. Most of these plants are widely used in traditional medicines, and furanoditerpenoids have therefore been disclosed with a wide range of bioactivities including anti-cancer, antiinflammation and anti-microorganism. To structure this review, the furanoditerpenoids were classified into seven types, including clerodane-type (Type I), labdane-type (Type II), cassane-type (Type III), abietane-type (Type IV), spongian-type (Type V), prenylbisabolane-type (Type VI) and miscellaneous type (Type VII). On the basis of 170 references, this review covers the distribution, phytochemistry, synthesis and pharmacological activities of furanoditerpenoids, describing 444 compounds. The information provided in this review might shed light on further research and development of furanoditerpenoids as potential therapeutic agents.

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ChemInform Abstract: A New Halimane Diterpenoid from Croton crassifolius

Zhang

et al. 2014

ChemInform

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A New Halimane Diterpenoid from Croton crassifolius

Cited by 19 publications

References 16 publications

Halimane diterpenoids: sources, structures, nomenclature and biological activities

Halimane diterpenoids: sources, structures, nomenclature and biological activities

Naturally occurring furanoditerpenoids: distribution, chemistry and their pharmacological activities

ChemInform Abstract: A New Halimane Diterpenoid from Croton crassifolius

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