A New Growth Substance, Β‐naphthoxyacetic Acid

Bausor, S. C.

doi:10.1002/j.1537-2197.1939.tb09296.x

Cited by 5 publications

(2 citation statements)

References 5 publications

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“…This is unique for this group of herbicides, and we will not cover the discovery of commercial plant growth regulators in this Review, as they are not pesticides. IAA was first identified in the literature in 1934 and soon after was reported to have profound effects on plant growth. , This was followed by the finding by several groups that natural analogs such as phenylacetic acid and the synthetic naphthylacetic acid have similar growth-regulating activities (e.g., refs − ). Making further analogs with plant growth effects had become an area of great interest in several laboratories.…”

Section: Herbicidesmentioning

confidence: 99%

Structure Simplification of Natural Products as a Lead Generation Approach in Agrochemical Discovery

Sparks¹,

Duke

2021

J. Agric. Food Chem.

103

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Natural products (NPs) have a long history as sources of compounds for crop protection. Perhaps a more important role for NPs has been as models and inspiration for the discovery and development of synthetic crop protection compounds. NPs and their synthetic mimics account for 18% of all crop protection compounds, whereas another 38% of all crop protection compounds have a NP that could have served as a model. Because NPs are often complex molecules, have limited availability, or possess structural features that constrain their suitability for use in agricultural settings, a key element in NP-inspired compounds is the simplification of the NP structure to provide a synthetically accessible molecule that possesses the physicochemical properties needed for use in crop protection. Herein we review a series of examples of NP mimics that demonstrate the structural or synthetic simplification of NPs as a guide for the discovery of future NP-inspired agrochemicals focused on fungicides, herbicides, and insecticides.

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Section: Herbicidesmentioning

confidence: 99%

Structure Simplification of Natural Products as a Lead Generation Approach in Agrochemical Discovery

Sparks¹,

Duke

2021

J. Agric. Food Chem.

103

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“…The term ''auxin'' was applied to any substance having these properties. Several years later, three independent groups demonstrated that naphthoxyacetic acid is an auxin (Bausor 1939;Irvine 1938;Zimmerman et al 1939). This finding was an important step because it led workers to study other substances having a different molecular ring structure connected to acetic acid by an oxygen link, such as, eventually, the phenoxyacetic acids.…”

Section: Scientific Background Of the Discoverymentioning

confidence: 99%

In the beginning: the multiple discovery of the first hormone herbicides

Troyer¹

2001

Weed Science

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The discovery of the first systemic or hormone herbicides, 2,4-D, 2,4,5-T, and MCPA, initiated an agricultural revolution and modern weed science. The finding of these herbicides was a striking case of multiple independent discovery by four groups of workers in two countries, the United Kingdom and the United States: William G. Templeman and associates at Imperial Chemical Industries; Philip S. Nutman and associates at the Rothamsted Agricultural Experiment Station; Franklin D. Jones at the American Chemical Paint Company; and Ezra Kraus, John Mitchell, and associates at the University of Chicago and the U.S. Department of Agriculture. Because of wartime and commercial secrecy, the usual procedures of scientific publication and patent disclosure were not followed; instead, the first scientific report on these herbicides occurred in a publication by workers who were not original discoverers. Considerable confusion consequently resulted concerning the discovery and the discoverers. This confusion has not been completely dispelled in subsequent years. The present report summarizes the complete story, clarifies the chronology of the discoverers and their publications, and makes the case that all four groups of workers deserve credit for this revolutionary advance. The scientific background of the discovery and events in its immediate aftermath, especially the ticklish patent situation, are also briefly chronicled.

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Response of Tomato Plants to Β‐naphthoxyacetic Acid

Bausor

1939

American J of Botany

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A New Growth Substance, Β‐naphthoxyacetic Acid

Cited by 5 publications

References 5 publications

Structure Simplification of Natural Products as a Lead Generation Approach in Agrochemical Discovery

Structure Simplification of Natural Products as a Lead Generation Approach in Agrochemical Discovery

In the beginning: the multiple discovery of the first hormone herbicides

Response of Tomato Plants to Β‐naphthoxyacetic Acid

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