A new generation of polyurethane vascular prostheses: Rara Avis or Ignis Fatuus?

Eberhart, Andreas; Zhang, Ze; Guidoin, Robert; Laroche, Gaétan; Guay, Louis; Faye, Dominique De La; Batt, Michel; King, Martin W.

doi:10.1002/(sici)1097-4636(1999)48:4<546::aid-jbm22>3.3.co;2-m

Cited by 14 publications

(16 citation statements)

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“…Combining the weather resistance, the biocompatibility (or hemocompatibility) and the thermal stability of PSis and the excellent mechanical properties of PUs makes PSiUs applicable as coating [1,2], medical [3] or flame retardant [4] materials. PSiUs, first of all their mechanical properties, still have challenges for researchers.…”

Section: Introductionmentioning

confidence: 99%

The effect of some disiloxane chain extenders on the thermal and mechanical properties of cross-linked poly(siloxane-urethane)s

Pusztai¹,

Kenyo²,

Nagy³

et al. 2013

Express Polym. Lett.

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Abstract. Poly(siloxane-urethane) (PSiU) networks based on a bis(hydroxyorgano) disiloxane chain extender, a trifunctional polyether polyol as a cross-linker, methylene-diphenyl diisocyanate and #,$-hydroxyethoxyethyl polydimethylsiloxane were synthesized in butyl acetate solution. The effect of the chain extenders and the cross-link density was investigated by using thermogravimetric analysis (TGA), dynamic mechanical thermal analysis (DMTA), swelling, hardness and tensile strength measurements. Isotherm thermogravimetric analyses were carried out for selected polymer compositions at 120 and 170°C and also the changes in tensile strength were followed. The different chain extenders have a strong effect on the hard segment structure, thus on the thermal and mechanical behaviour. The phase separation of the soft and hard segments was indicated by the two or three well distinguished tan% peaks, the maxima of which range within wide intervals depending on the polymer composition. The polymers of high cross-link density showed a very good thermal stability, high tensile strength (up to 68.7 MPa) and hardness (80-95 Shore A) even of high 13-36% dimethyl siloxane content. Changing the siloxane soft segment ratio and the cross-link density the physical properties can be adjusted.

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Section: Introductionmentioning

confidence: 99%

The effect of some disiloxane chain extenders on the thermal and mechanical properties of cross-linked poly(siloxane-urethane)s

Pusztai¹,

Kenyo²,

Nagy³

et al. 2013

Express Polym. Lett.

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“…The main reason for interest in PUs is because of their excellent physical properties, such as elasticity, abrasion resistance, durability, chemical stability and easy processability [87]. These properties enable the use of PUs in several biomedical applications [86], including pacemaker lead insulation [88,89], breast implants [90,91], heart valves [92,93], vascular prostheses [94,95], bioadhesives [96,97] and vehicles for controlled delivery of active compounds [98,99].…”

Section: Polyurethanementioning

confidence: 99%

Designing polymeric microparticles for biomedical and industrial applications

Campos

Branquinho

Carreira

et al. 2013

European Polymer Journal

153

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“…In contrast, it is known that several types of polyurethanes (PUs) are satisfactory materials in solving thrombosis and operability problems because of their excellent elastic properties and their biocompatible, microporous structure. 11,12 Responsibility, or the 'compliance' value, for the heart cycle is very important in a vascular graft. When the compliance value for the vascular graft made from SF fiber is lower than that of a native vascular graft, it is indicative of thrombosis or intimal thickening.…”

Section: Introductionmentioning

confidence: 99%

Structural characterization of silk-polyurethane composite material for biomaterials using solid-state NMR

Nakazawa

Asano

Nakazawa

et al. 2012

Polym J

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In this paper, we performed solid-state nuclear magnetic resonance (NMR) measurements, including T 1 H and T 1q , of silk fibroin (SF)/polyurethane (PU) composites to examine their possible use as a material for artificial vascular grafts. In the development of new artificial vascular grafts made from SF/PU, it is important to examine the miscibility of the composites and their molecular dynamics, because these properties are intimately involved in the resulting physical properties of the resulting vascular graft. The T 1 H measurements showed that the domain size of the SF/PU ¼ 1:1 composite is smaller than the domain size of the 1:10 and 1:2 composites, indicating that the molecular miscibility between SF and PU are partially in close proximity, particularly in the SF/PU ¼ 1:1 composite. Additionally, we observed that the molecular motion of the soft segment of PU in the SF/PU composites becomes slow, suggesting that the soft segment of PU interacts with SF to some extent. These analyses provided basic structural information for the development of silk-based artificial vascular grafts using PU.

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A new generation of polyurethane vascular prostheses: Rara Avis or Ignis Fatuus?

Cited by 14 publications

References 0 publications

The effect of some disiloxane chain extenders on the thermal and mechanical properties of cross-linked poly(siloxane-urethane)s

The effect of some disiloxane chain extenders on the thermal and mechanical properties of cross-linked poly(siloxane-urethane)s

Designing polymeric microparticles for biomedical and industrial applications

Structural characterization of silk-polyurethane composite material for biomaterials using solid-state NMR

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