A New Generation of Nutra-ceuticals and Cosme-ceuticals Complexing Lipophilic Bioactives with -Cyclodextrin

Uekaji, Yukiko; Jo, Ayako; Ohnishi, Mayu; Nakata, Daisuke; Terao, Keiji

doi:10.1016/j.proeng.2012.03.079

Cited by 11 publications

(3 citation statements)

References 15 publications

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“…In the presence of taurocholic acid and lecithin, CP (PP/γCD) was less affected by the supersaturation phenomenon than CP (PP/αCD), possibly because αCD has been reported to easily form the inclusion complex with lecithin. Furthermore, guest drugs of the γCD inclusion complex can be easily encapsulated in taurocholic acid . With CP (PP/αCD), the solubilized PP molecules were incorporated into the mixed micelles with αCD forming an inclusion complex with lecithin that induced the supersaturation phenomenon.…”

Section: Results and Discussionmentioning

confidence: 99%

“…Furthermore, guest drugs of the γCD inclusion complex can be easily encapsulated in taurocholic acid. 27 With CP (PP/αCD), the solubilized PP molecules were incorporated into the mixed micelles with αCD forming an inclusion complex with lecithin that induced the supersaturation phenomenon. With CP (PP/γCD), PP was encapsulated in taurocholic acid that helped to maintain solubility.…”

Section: Examination Of Dissolution Characteristics In Fassifmentioning

confidence: 99%

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Solubility of Piperine and Its Inclusion Complexes in Biorelevant Media and Their Effect on Attenuating Mouse Ileum Contractions

et al. 2021

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This study evaluated the solubility of piperine (PP) in biorelevant media and the effect of its ground mixtures (GMs) and coprecipitates (CPs) on intestinal contractions when presented in inclusion complexes with α-, β-, and γ-cyclodextrins (CDs). In the powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) measurements, CP (PP/αCD) and CP (PP/γCD) suggest the formation of inclusion complexes. The 1 H-nuclear magnetic resonance (NMR) analysis showed the integrated intensity ratios of CP (PP/αCD) and CP (PP/γCD) protons to be 1/2 and 1/1, the same as the respective molar ratios in the respective GM inclusion complexes. The intestinal contraction test confirmed that the intestinal contraction rate of carbachol (CCh) in the presence of 2.0 × 10 –5 M PP was comparable to that in the absence of PP. On the other hand, CP (PP/αCD), GM (PP/αCD = 1/2), and GM (PP/βCD = 1/1) formed inclusion complexes that significantly suppressed the intestinal contractility at PP 1.0 × 10 –8 M. No significant differences were observed between CP and GM. The solubility of the PP/αCD inclusion complex was 6–7 times higher than that of PP in the fasted-state-simulated intestinal fluid (FaSSIF, pH 6.5). PP functioned to suppress intestinal contraction by forming an inclusion complex. Based on this result, PP/αCD might be expected to be effective as an antidiarrheal.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Examination Of Dissolution Characteristics In Fassifmentioning

confidence: 99%

Solubility of Piperine and Its Inclusion Complexes in Biorelevant Media and Their Effect on Attenuating Mouse Ileum Contractions

et al. 2021

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“…These studies concluded that the RLA-γ-CD enhances the dissolution of RLA in small intestine lumen which leads to increased absorption in the intestine (Uchida et al, 2015). Another study also inferred the suitability of γ-CD inclusion complex for different formulations in the supplementation of RLA (Uekaji et al, 2012). According to the researchers, the increase in absorption may be because of the formation of micelles from γ-CD complex with bile acid and replacement of coenzyme Q10.…”

Section: Encapsulation Techniques For Lamentioning

confidence: 97%

Recent developments in encapsulation of α-lipoic acid for enhanced bioavailability and stability

Choudhary

Dutta²,

Moses³

et al. 2023

Qual. Assur. Saf. Crops Foods

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α-lipoic acid (LA) is a potent antioxidant available in various plant and animal sources. Of late, there is high market demand for LA-based nutraceuticals, owing to enhanced occurrences of oxidative stress-based diseases. However, the effectiveness of LA is challenged with its low solubility, less stability, and low bioavailability. In addition, the unpleasant taste of LA limits its applications in food systems. In this context, encapsulation techniques can modify the chemical and biological properties of LA and improve its solubility and stability in the aqueous medium, which in turn helps in the development of different innovative therapeutic products based on LA. Different encapsulation techniques such as inclusion complexes, spray drying, electrospraying, solid lipid nanoparticles (SLN), emulsification, and liposomes have been explored for the encapsulation of LA. This review focuses on the biological activities of LA in terms of antioxidant, antidiabetic, anticancer, and anti-inflammatory properties, and the scope of encapsulation to enhance these properties, as evidenced through in vitro and in vivo studies. Furthermore, this article will help researchers and industrialists to select the suitable encapsulation method based on their requirement for delivering LA to achieve its optimal therapeutic potential.

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Cyclodextrins

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A New Generation of Nutra-ceuticals and Cosme-ceuticals Complexing Lipophilic Bioactives with -Cyclodextrin

Cited by 11 publications

References 15 publications

Solubility of Piperine and Its Inclusion Complexes in Biorelevant Media and Their Effect on Attenuating Mouse Ileum Contractions

Solubility of Piperine and Its Inclusion Complexes in Biorelevant Media and Their Effect on Attenuating Mouse Ileum Contractions

Recent developments in encapsulation of α-lipoic acid for enhanced bioavailability and stability

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