A new gas chromatography/mass spectrometry method for the simultaneous analysis of target and non-target organic contaminants in waters

Gómez, María José; Gómez-Ramos, M.M.; Agüera, Ana; Mezcúa, Milagros; Herrera, Sonia; Fernández‐Alba, Amadeo R.

doi:10.1016/j.chroma.2009.02.085

Cited by 113 publications

(57 citation statements)

References 33 publications

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“…The GC oven temperature program was as follows: 908C (1 min hold); ramp to 1508C at 58C/min, ramp to 2608C at 38C/min, and final ramp to 3208C at 208C/min (5 min hold). A 10-min post run at 3308C with helium backflush was preprogrammed to remove high-boiling components through the split vent to minimize carryover and retention time shift [13]. The split/splitless injector and m-ECD were maintained isothermal at 2808C and 3508C, respectively.…”

Section: Gc Analysismentioning

confidence: 99%

Analysis, occurrence, and toxic potential of pyrethroids, and fipronil in sediments from an urban estuary

Lao

Tsukada

Greenstein

et al. 2010

Enviro Toxic and Chemistry

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Eight pyrethroids and fipronil and its three major degradates were analyzed in urban estuarine sediments that exhibited a range of toxic effects to an amphipod test species. Sediments from Ballona Creek, an urban estuary in Southern California (USA), collected during three dry season events were analyzed by gas chromatography with electron capture and negative chemical ionization mass spectrometric detection (GC-ECD and GC-NCI-MS). The two detection methods were in agreement for intermediate levels of pyrethroid contamination (10-50 ng/g dry wt) but deviated for both low and high concentrations (< 5 and > 50 ng/g). Sediments contained total pyrethroids as high as 473 ng/g with permethrin, bifenthrin, and cypermethrin as the most abundant compounds. In contrast, fipronil and its desulfinyl, sulfide, and sulfone degradates were detected at much lower levels (

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Section: Gc Analysismentioning

confidence: 99%

Analysis, occurrence, and toxic potential of pyrethroids, and fipronil in sediments from an urban estuary

Lao

Tsukada

Greenstein

et al. 2010

Enviro Toxic and Chemistry

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“…However, due to the existence of various chemical contaminants at low concentrations in source waters and the lack of data on genotoxicity of many pollutants, identifying the chemical responsible for genotoxicity is not an easy task with respect to source waters. Recently, the availability of analytic methods for simultaneous analysis of organic contaminants makes it possible to quickly and sensitively determine possible pollutants in different water bodies [20]. The QSAR Toolbox comprises software developed to fill gaps in (eco-)toxicological data for assessment of chemical hazards, and to provide robust categorization of chemicals suitable to fill data gaps in genetic toxicity.…”

Section: Introductionmentioning

confidence: 99%

Assessing of genotoxicity of 16 centralized source-waters in China by means of the SOS/umu assay and the micronucleus test: Initial identification of the potential genotoxicants by use of a GC/MS method and the QSAR Toolbox 3.0

Yan

Jiang²,

Na³

et al. 2014

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Only few studies were conducted to assess genotoxicity of centralized source waters in China and almost none of them dealt with the causal relationship between the genotoxic effect and genotoxicants. In this work, 16 centralized source waters in China were sampled from five river systems and genotoxicity of their organic extracts was assessed by use of the SOS/umu test for DNA-damaging effect and the miniaturized flow cytometry-based micronucleus (MN) test for chromosome-damaging effect. In addition, initial identification of potential genotoxicants for the six samples from the Yangtze River was done with a GC/MS method and the QSAR toolbox 3.0. The results demonstrate that eight samples showed both indirect and direct DNA-damaging effects, another four samples showed only indirect DNA-damaging effects, while chromosome-damaging effects were found for 14 out of the 16 samples, in which aneugenic and clastogenic modes of action were found for 4 and 10 samples, respectively. Both direct/indirect DNAdamaging effects and chromosome-damaging effects were induced by the six Yangtze River samples, and the existing different types of genotoxicant confirmed the results. Furthermore, o-phenylphenol was initially identified as the major cause for the DNA-damaging effects while PAHs, pesticides, phenol and anthraquinone were identified as ubiquitous chromosome-damaging agents among these samples. In conclusion, a combination of the SOS/umu test and the miniaturized flow cytometry-based MN test to detect both DNA-damaging and chromosome-damaging effects could be used as a comprehensive genotoxicity assessment tool for the evaluation and classification of genotoxicity of complex mixtures, and potential genotoxicants can be initially identified with additional information from chemical analysis and the QSAR toolbox.

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“…The deconvolution parameters in AMDIS were fixed as follows: adjacent peak subtraction: one; resolution: medium; sensitivity: high; shape requirements: medium. More details on DRS settings can be found in Agilent's application notes and literature elsewhere [18][19][20]. In this study, an adapted version of CHEMS-1 was used to rank contaminants in water samples.…”

Section: Automatic Screening and Identification Of Chemicalsmentioning

confidence: 99%

Identification and ranking of the risky organic contaminants in the source water of the Danjiangkou reservoir

Wang

2013

Front. Environ. Sci. Eng.

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The Danjiangkou reservoir was selected to provide the source water for the middle routes of the South to North Water Transfer Project, which has provoked many environmental concerns. To date, investigations of water contamination of the source water of the Danjiangkou reservoir with organic micro-pollutants have been limited. This study was conducted to identify and rank organic contaminants that pose risks in the Danjiangkou reservoir. To this end, the Chemical Hazard Evaluation and Management Strategies (CHEMS-1) approach was adapted to integrate the deconvolution technology of qualitative identifying contaminants for site-specific environmental matrices. The samples were screened for the presence of 1093 contaminants using deconvolution technologies and the hazard values of the identified contaminants were calculated using the adapted CHEMS-1 approach according to their hazardous properties and occurrence in source water. The results showed that 46 contaminants from 1093 targets were present in Danjiangkou water, 23 of which appeared at frequencies higher than 50%, and 15 of which were identified as priorities. Over half (53%) of the highranked contaminants were polycyclic aromatic hydrocarbons (PAHs), with chrysene ranked highest on the list. Health risk assessment of the top-ranked PAHs was conducted and revealed that cancer risks of PAHs detected in the source water of Danjiangkou to different populations ranged from 10 -7 to 10 -6, indicating a low cancer risk to consumers. The results of this study indicated that the adapted CHEMS-1 approach was feasible for site-specific screening of organic contaminants to identify and rank potential priority pollutants.

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A new gas chromatography/mass spectrometry method for the simultaneous analysis of target and non-target organic contaminants in waters

Cited by 113 publications

References 33 publications

Analysis, occurrence, and toxic potential of pyrethroids, and fipronil in sediments from an urban estuary

Analysis, occurrence, and toxic potential of pyrethroids, and fipronil in sediments from an urban estuary

Assessing of genotoxicity of 16 centralized source-waters in China by means of the SOS/umu assay and the micronucleus test: Initial identification of the potential genotoxicants by use of a GC/MS method and the QSAR Toolbox 3.0

Identification and ranking of the risky organic contaminants in the source water of the Danjiangkou reservoir

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