A new fusarielin analogue from Penicillium sp. isolated from the Mediterranean sponge Ircinia oros

Chen, Huiqin; Aktas, Nihal; Konuklugil, Belma; Mándi, Attila; Δαλέτος, Γεώργιος; Lin, Wen Han; Dai, Hao‐Fu; Kurtán, Tibor; Proksch, Peter

doi:10.1016/j.tetlet.2015.07.072

Cited by 19 publications

(14 citation statements)

References 19 publications

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“…FSL3 can play a similar role in fusarielin biosynthesis to form the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond. Recently, fusarielin I was identified in a marine Penicillium strain, which differs from the known fusarielins in the absence of a C11=C12 cis double bond [20]. This indicates enoyl reductions at C10=C11 and C12=C13 in this fungus and future analyses can shed light on how the gene cluster is organized.…”

Section: Posmentioning

confidence: 84%

Functional Analysis of the Fusarielin Biosynthetic Gene Cluster

et al. 2016

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Abstract:Fusarielins are polyketides with a decalin core produced by various species of Aspergillus and Fusarium. Although the responsible gene cluster has been identified, the biosynthetic pathway remains to be elucidated. In the present study, members of the gene cluster were deleted individually in a Fusarium graminearum strain overexpressing the local transcription factor. The results suggest that a trans-acting enoyl reductase (FSL5) assists the polyketide synthase FSL1 in biosynthesis of a polyketide product, which is released by hydrolysis by a trans-acting thioesterase (FSL2). Deletion of the epimerase (FSL3) resulted in accumulation of an unstable compound, which could be the released product. A novel compound, named prefusarielin, accumulated in the deletion mutant of the cytochrome P450 monooxygenase FSL4. Unlike the known fusarielins from Fusarium, this compound does not contain oxygenized decalin rings, suggesting that FSL4 is responsible for the oxygenation.

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Section: Posmentioning

confidence: 84%

Functional Analysis of the Fusarielin Biosynthetic Gene Cluster

et al. 2016

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“…yielded the fusarielin analogue 432 when grown axenically but coculture of this strain with another Penicillium strain obtained from the same sponge elicited production of the known compounds norlichexanthone 270 and monocerin 271 433 (rst time MNP), neither of which was detected in the individual axenic cultures of the two strains. 272 A so coral-related Pestalotiopsis sp. was the source of enantiomeric alkaloid dimers (+)-and (À)-pestaloxazine A 434 and 435.…”

Section: Marine-sourced Fungi (Excluding From Mangroves)mentioning

confidence: 99%

Marine natural products

et al. 2017

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Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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“…As for the compounds, this overview does not consider primary metabolites mentioned in the cited references, including ergosterol and structurally related compounds [ 9 , 10 ]. Additional exclusions concern other common compounds which often represent intermediates in the synthesis of more complex secondary metabolites, such as orsellinic acid [ 11 , 12 ], and products obtained from mutant strains [ 13 , 14 , 15 ], or through co-cultivation of two or more strains [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds Produced by Strains of Penicillium and Talaromyces of Marine Origin

Nicoletti¹,

Trincone

2016

Marine Drugs

121

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In recent years, the search for novel natural compounds with bioactive properties has received a remarkable boost in view of their possible pharmaceutical exploitation. In this respect the sea is entitled to hold a prominent place, considering the potential of the manifold animals and plants interacting in this ecological context, which becomes even greater when their associated microbes are considered for bioprospecting. This is the case particularly of fungi, which have only recently started to be considered for their fundamental contribution to the biosynthetic potential of other more valued marine organisms. Also in this regard, strains of species which were previously considered typical terrestrial fungi, such as Penicillium and Talaromyces, disclose foreground relevance. This paper offers an overview of data published over the past 25 years concerning the production and biological activities of secondary metabolites of marine strains belonging to these genera, and their relevance as prospective drugs.

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A new fusarielin analogue from Penicillium sp. isolated from the Mediterranean sponge Ircinia oros

Cited by 19 publications

References 19 publications

Functional Analysis of the Fusarielin Biosynthetic Gene Cluster

Functional Analysis of the Fusarielin Biosynthetic Gene Cluster

Marine natural products

Bioactive Compounds Produced by Strains of Penicillium and Talaromyces of Marine Origin

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